DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar2 and GLR2

DIOPT Version :9

Sequence 1:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster
Sequence 2:	NP_001318239.1	Gene:	GLR2 / 816231	AraportID:	AT2G17260	Length:	925	Species:	Arabidopsis thaliana

Alignment Length:	1023	Identity:	222/1023 - (21%)
Similarity:	405/1023 - (39%)	Gaps:	245/1023 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 GGGSLSKGAAANKEQ-LNIGLIAPHTNFGKREYLRSINNAVTGLTKTRGAKLTFLKDYSFEQKNI 149
            ||..||:||::::.. :.:|.|     ||.        |.:.|.|    |.:.|    ...::::
plant    18 GGLLLSEGASSSRPPVIKVGAI-----FGL--------NTMYGET----ANIAF----KAAEEDV 61

  Fly   150 HFDMMSLTPSPTAILSTLCK-----------EFLRVNVSAILYMMNNEQFGHSTASAQYFL-QLA 202
            :.|...|..|...||....|           :|:..:|.||:        |..|:...:.| .||
plant    62 NSDPSFLGGSKLRILMNDAKRSGFLSIMGALQFMETDVVAII--------GPQTSIMAHVLSHLA 118

  Fly   203 GYLGIPVISWNADNSGLERRASQSTLQ----LQLAPSIEHQSAAMLSILERYKWHQFSVVTSQIA 263
            ..|.:|::|:.|.:..|      |.||    :|.|||......|:..::..|.|   |.|.:...
plant   119 NELTVPMLSFTALDPTL------SPLQFPFFVQTAPSDLFLMRAIAEMITYYGW---SDVVALYN 174

  Fly   264 GHDDFVQAVRERVAEMQEH-----FKFTILNSIVVTR----TSDLMELVNSEARVMLLYATQTEA 319
            ..|:....|.....|::|.     :|..:...:|:|.    ..:|:::...|:||:::.......
plant   175 DDDNSRNGVTALGDELEERRCKISYKAVLPLDVVITSPVEIIEELIKIRGMESRVIVVNTFPNTG 239

  Fly   320 ITILRAAEEMKLTGENYVWVVS---QSVIEKKDAHSQFPV------GMLGVHFDTS--------S 367
            ..|.:.||.:.:..:.|||:.:   .||::     |..|:      |:|.:...|.        :
plant   240 KMIFKEAERLGMMEKGYVWIATTWLSSVLD-----SNLPLDTKLVNGVLTLRLHTPDSRKKRDFA 299

  Fly   368 AALMNEISN--AIKIYSYGVEAY---------------------LTDPAN----RDRRLTTQSLS 405
            |...|::||  .|.:..||:.||                     .::.|.    :...|...:||
plant   300 ARWKNKLSNNKTIGLNVYGLYAYDTVWIIARAVKTLLEAGGNLSFSNDAKLGSLKGEALNLSALS 364

  Fly   406 CEDEGRGRWDNGEIFFKYLRNVSIEGDLNKPNIEFTADGDLRSAELKIMNLRPSANNKNLVWE-- 468
                   |:|.|.....|:.:..:.| |..| ::|..|..:         |:||.:..|||.:
plant   365 -------RFDQGSQLLDYIVHTKMSG-LTGP-VQFHPDRSM---------LQPSYDIINLVDDRV 411

  Fly   469 -EIGVWKSW------------------ETQKLDIRDIAWPGNSHAPPQGVPEKFHLKITFLEEAP 514
             :||.|.::                  .:....:..:.|||.:...|:|        ..|.....
plant   412 HQIGYWSNYSGLSIVPPESFYSKPPNRSSSNQHLNSVTWPGGTSVTPRG--------WIFRNNGR 468

  Fly   515 YINLSPADPVSGKCLMDRGVLCRVAADHEMAADIDVGQAHRNESFYQCCSGFCIDLLEKFAEELG 579
            .:.:...|..|.|..:.|               :: |.:::       ..|:|||:.|...:.|.
plant   469 RLRIGVPDRASFKDFVSR---------------VN-GSSNK-------VQGYCIDVFEAAVKLLS 510

  Fly   580 F--TYELVRVEDGKWGTLENGKWNGLIADLVNRKT-----DMVLTSLMINTEREAVVDFSEPFME 637
            :  .:|.:...||    |.|..:|    :|||:.|     |.|:..:.|.|:|..:|||::|::|
plant   511 YPVPHEFIFFGDG----LTNPNYN----ELVNKVTTGVDFDAVVGDIAIVTKRTRIVDFTQPYIE 567

  Fly   638 TGIAIVVAKRTGI-ISPTAFLEPFDTASWMLVGIVAIQAATFMIFLFEWLSPSGYDMKLYLQNTN 701
            :|: :|||..|.: .:|.|||.||....|      |:.|:.|:|     :..:.:.::..:.:..
plant   568 SGL-VVVAPVTRLNENPWAFLRPFTLPMW------AVTASFFVI-----VGAAIWILEHRINDEF 620

  Fly   702 VTPYRFSLFRTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAAFMITREE 766
            ..|.|..:....|..::.:|.:  |.::......|.:..:|....::..:.|||:|.:.:..::.
plant   621 RGPPRRQIITILWFTFSTMFFS--HRETTVSTLGRMVLLIWLFVVLIITSSYTASLTSILTVQQL 683

  Fly   767 FHEFSGLNDSRLVHPFSHKPSFKFGTIPYSH-TDSTIHKYFNVMHNYMRQYNKTSVADGVAAVLN 830
            .....|::  .|:.. :.:..|:.|:...:: ||.     .|:..:  |.....|..:...|:.|
plant   684 NSPIKGVD--TLISS-TGRIGFQVGSFAENYMTDE-----LNIASS--RLVPLASPEEYANALQN 738

  Fly   831 GNLDSFIYDGTVLDYLVAQDEDCRLMTVGSWYAMTGYGLAFSRNSKYVQMFNKRLLEFRANGDLE 895
            |.:.:.:.:...:|..::  :.|:....|..:...|:|.||.|:|......:..:|.....|:|:
plant   739 GTVAAIVDERPYIDLFLS--DYCKFAIRGQEFTRCGWGFAFPRDSPLAVDMSTAILGLSETGELQ 801

  Fly   896 RLRRYWMT-GTC-RPGKQEHKSSDPLALEQFLSAFLLLMAGILLAALLLLLEHVYFKYIRKRLAK 958
            ::...|:: ..| .|...:...|:.|.:..|...||::  ||  |.|:.|..| :||.||...
plant   802 KIHDRWLSKSNCSSPHGSQSGDSEQLNVHSFWGMFLVV--GI--ACLVALFIH-FFKIIRDFC-- 859

  Fly   959 KDGGHCCALISLSMGKS------LTFRGAVFEATE----ILKKHRCND 996
            ||........::...||      .||...|.|..|    .||:.|.||
plant   860 KDTPEVVVEEAIPSPKSSRLTKLQTFLAFVDEKEEETKRRLKRKRNND 907

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	97/481 (20%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	85/416 (20%)
		Lig_chan	665..928	CDD:278489	46/265 (17%)
GLR2	NP_001318239.1	PBP1_GABAb_receptor	35..424	CDD:107361	96/449 (21%)
		GluR_Plant	468..808	CDD:270404	82/396 (21%)
		Lig_chan	594..843	CDD:306551	50/277 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910