DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nmdar2 and grid1a

DIOPT Version :9

Sequence 1:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster
Sequence 2:	XP_021323097.1	Gene:	grid1a / 793756	ZFINID:	ZDB-GENE-120411-28	Length:	1044	Species:	Danio rerio

Alignment Length:	1019	Identity:	241/1019 - (23%)
Similarity:	404/1019 - (39%)	Gaps:	250/1019 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 LLLTVLTLLILDTRSCQGLRLTNGGGSLSKGAAANKEQLNIGLIAPHTNFGKREYLRSINNAVTG 127
            ||:..|:|.||..||.:...:.:.|....:.|..:.|...:                    |::.
Zfish     3 LLVISLSLWILQCRSARADSIIHIGAIFEQNAIRDDEVFQL--------------------AISD 47

  Fly   128 LTKTRGAKLTFLKDYSFEQKNIHFDMMSLTP-SPTAILSTLCKEFLRVNVSAILYMMNNEQFGHS 191
            |:         |.|...:.:.|...:..:.| :|...:...| |.:...:.|::         .|
Zfish    48 LS---------LNDDILQSERITHSIKLIEPNNPFQAVQEAC-ELMNQGILALV---------SS 93

  Fly   192 T--ASAQYFLQLAGYLGIPVISWNADNSGLERRASQSTLQLQLAPSIEHQSAA----------ML 244
            |  |:|.....|...:.||.:....:..|..|    :..||..:|..|..:.|          |:
Zfish    94 TGCAAANALQSLTDAMHIPHLFIQRNGDGTPR----AECQLNPSPDGERYTLAARPPVRLNDVMI 154

  Fly   245 SILERYKWHQFSVV---------------TSQIAGHDDFVQAVRERVAEMQEHFKFTILNSIVVT 294
            :::...:||:|.|.               .:...|.|..:|.|...|.::     |:.|.|.:
Zfish   155 TLVSELRWHKFIVFYDSEYDVRGLRGFLDQASRMGLDVSLQQVDRNVTKV-----FSTLFSTM-- 212

  Fly   295 RTSDLMELVNSEARVMLLYATQTEAITILRAAEEMKLTGENYVWVVSQSVIEKKD----AHSQ-- 353
            |..:|....::..|.:||.:.:|..:.|.:|. |..|..::..||.:...:...:    .||.
Zfish   213 RMEELNRYRDTLRRAILLLSPRTAQVFIHQAV-ETNLASKDSHWVYANEEVSDTEIMELVHSALG 276

  Fly   354 --------FPVGMLGVHFDTSSAALMN--EISNAI----KIYSYGVEA---YLTDP----AN--- 394
                    ||:..     ||:...:.|  .||:.:    :.|...:|.   ||.|.    ||
Zfish   277 RMTVIRQIFPLWR-----DTNIRCMRNNHRISSLLCDPQEGYLQSLEVSSLYLYDSVLMLANAFY 336

  Fly   395 ---RDRRL-TTQSLSCEDEGRGRWDNGEIFFKYLRNVSIEGDLNKPNIEFTADGDLRSAELKIMN 455
               .||:. :..||:|..:....|:.|......::...|.|        .|.          :|:
Zfish   337 RKLEDRKWHSMASLNCMRKSTKPWNGGWSMLDTIQKGRISG--------LTG----------LMD 383

  Fly   456 LRPSANNKNLVWEEIGVWKSWETQKLDIRDIA-WPGN------------SHAPPQGVPEKFHLKI 507
            .|.:..|.::.:|.:|...| ||...|::.:| |..:            .|. .||:.    ||:
Zfish   384 FRSNGANSHVQFEILGTSYS-ETFGKDVKRLATWDSDRGLNGSLRENRADHG-MQGIT----LKV 442

  Fly   508 TFLEEAPYINLSPADPVSGKCLMDRGVLCRVAADHEMAADIDVGQAHRNESFYQCCSGFCIDLLE 572
            ..|.|.|::                           |.|:..:||..|.:       ||.||:|:
Zfish   443 VTLLEEPFV---------------------------MVAENILGQPKRYK-------GFSIDVLD 473

  Fly   573 KFAEELGFTYELVRVEDGKWGTLE-NGKWNGLIADLVNRKTDMVLTSLMINTEREAVVDFSEPFM 636
            ..|:.|||.||:.:|.|.|:|:.: ||.|||:|.:|:.::.|:.::::.|..|||.|||||:.::
Zfish   474 ALAKILGFKYEMYQVADAKYGSPQTNGSWNGMIGELIGKRADVAISAITITPERENVVDFSKRYL 538

  Fly   637 ETGIAIVVAKRTGIISPTAFLEPFDTASWMLVGIVAIQAATFMIFLFEWL------SPSGYDMKL 695
            :..:.|::.|....::..:.|.|||.|.|..:. .||.....|:||...:      :|.|..
Zfish   539 DYSVGILMTKTEERLNIFSLLAPFDLAVWACIA-AAIPVVGVMVFLLRRVQSVRSQNPPGPH--- 599

  Fly   696 YLQNTNVTPYRFSLFRTYWLVWAVLFQAAVHVDSPRGFTS----RFMTNVWALFAVVFLAIYTAN 756
              |..:||.   |.....|:|:....|     .....|.|    |.....|.||.::..:.||||
Zfish   600 --QPASVTT---SFQSAIWIVYGAFVQ-----QGGESFMSSMALRIAMGSWWLFTLIVCSSYTAN 654

  Fly   757 LAAFM-ITREEFHEFSGLNDSRLVHPFSHKPSFKFGTIPYSHTDSTIHKYFNV-----------M 809
            |||:: ::|.:       |..|.....|.:....:||:    .:|.:.:||.|           .
Zfish   655 LAAYLTVSRMD-------NAIRTFQDLSKQSEINYGTV----RESAVFEYFRVKGTNPLEQDSTF 708

  Fly   810 HNYMRQYNK--------TSVADGVAAVLNGNLDSFIYDGTVLDYLVAQDEDCRLMTVGSWYAMTG 866
            ....|..||        ||.|:|:..|..... :|::|..||:|....|:||.|:..|:..:..|
Zfish   709 AELWRTINKNQGQDNSVTSPAEGIRKVKRDPY-AFLWDMAVLEYAALTDDDCTLVVTGNGMSSKG 772

  Fly   867 YGLAFSRNSKYVQMFNKRLLEFRANGDLERLRRYW--MTGTCRPGKQEHKSSD--PLALEQFLSA 927
            ||||....|.|..:|::::|:.:..|||:.|::.|  ..|.|...|.....::  .|.|..|...
Zfish   773 YGLALQHGSPYRDLFSQKILDLQEKGDLDILKQKWWPRKGRCDLDKHAEPQTEGRALRLHSFAGV 837

  Fly   928 FLLLMAGILLAALLLLLEHVYFKYIRKRLAKKDGGHCCALISLS 971
            |.:|.||:|||.|:..||..:.....:|...|:....|||..:|
Zfish   838 FCILAAGLLLACLVAALESWWNGPRCQRAQPKEDTKGCALEMVS 881

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	87/453 (19%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	121/438 (28%)
		Lig_chan	665..928	CDD:278489	76/296 (26%)
grid1a	XP_021323097.1	Periplasmic_Binding_Protein_Type_1	25..424	CDD:324556	89/473 (19%)
		PBP2_iGluR_delta_1	437..809	CDD:270448	120/435 (28%)
		DNA_pol3_gamma3	<915..1044	CDD:331207
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591145
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740