DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nmdar2 and Grid2

DIOPT Version :9

Sequence 1:NP_001014714.1 Gene:Nmdar2 / 31107 FlyBaseID:FBgn0053513 Length:1083 Species:Drosophila melanogaster
Sequence 2:NP_077355.2 Gene:Grid2 / 79220 RGDID:68368 Length:1007 Species:Rattus norvegicus


Alignment Length:965 Identity:227/965 - (23%)
Similarity:387/965 - (40%) Gaps:217/965 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    95 AANKEQLNIGLIAPHTNFGKREYLRSINNAVTGLTKT----RGAKLTFLKDYSFEQKNIHFDMMS 155
            |.:...::||.|...:.....|..|:   ||..|.:.    :..|:||  ..:|...|       
  Rat    21 ATSDSIIHIGAIFDESAKKDDEVFRT---AVGDLNQNEEILQTEKITF--SVTFVDGN------- 73

  Fly   156 LTPSPTAILSTLCKEFLRVNVSAILYMMNNEQFG--HSTASAQY----FLQLAGYLGIPVISWNA 214
               :|...:...| |.:...:.|::..:.....|  .|.|.|.:    |:| ....|.|     .
  Rat    74 ---NPFQAVQEAC-ELMNQGILALVSSIGCTSAGSLQSLADAMHIPHLFIQ-RSTAGTP-----R 128

  Fly   215 DNSGLERRASQSTLQLQLAPSIEHQSAAMLSILERYKWHQFSVVTS---QIAGHDDFVQAVRERV 276
            ...||.|........|.:.|.: :.:..:|.::..|.|.:|.:...   .|.|..:|:..|.::.
  Rat   129 SGCGLTRSNRNDDYTLSVRPPV-YLNEVILRVVTEYAWQKFIIFYDSEYDIRGIQEFLDKVSQQG 192

  Fly   277 AEMQEHFKFTILNSIVVT-----RTSDLMELVNSEARVMLLYATQTEAITILRAAEEMKLTGENY 336
            .::........:|.::.|     |..:|....::..|.:|:....| |.:.:....|..|...:.
  Rat   193 MDVALQKVENNINKMITTLFDTMRIEELNRYRDTLRRAILVMNPAT-AKSFISEVVETNLVAFDC 256

  Fly   337 VWVVSQSVIEKKDA--------------HSQFPVG-------MLGVHFDTSSA-------ALMNE 373
            .|::....|...|.              ...|||.       ..|.|..:|:.       |...|
  Rat   257 HWIIINEEINDVDVQELVRRSIGRLTIIRQTFPVPQNISQRCFRGNHRISSTLCDPKDPFAQNME 321

  Fly   374 ISNAIKIYSYGVEAYLTDPANR---DRRL-TTQSLSCEDEGRGRWDNGEIFFKYLRNVSIEGDLN 434
            |||   :|.|.....|.:..::   ||:. :..||||..:....|..|....:.::...:.|   
  Rat   322 ISN---LYIYDTVLLLANAFHKKLEDRKWHSMASLSCIRKNSKPWQGGRSMLETIKKGGVNG--- 380

  Fly   435 KPNIEFTADGDLRSAELKIMNLRPSANNKNLVWEEIGVWKSWETQKLDIRDI-AWPGNSHAPPQG 498
                   ..|||...|        :..|.|:.:|.:|.....|..: .:|.: .|          
  Rat   381 -------LTGDLEFGE--------NGGNPNVHFEILGTNYGEELGR-GVRKLGCW---------- 419

  Fly   499 VPEKFHLKITFLEEAPYINLSPADPVSG--KCLMD-------RGVLCRVAADHE----MAADIDV 550
                                   :||:|  ..|.|       |||:.||....|    |.::..:
  Rat   420 -----------------------NPVTGLNGSLTDKKLENNMRGVVLRVVTVLEEPFVMVSENVL 461

  Fly   551 GQAHRNESFYQCCSGFCIDLLEKFAEELGFTYELVRVEDGKWGT-LENGKWNGLIADLVNRKTDM 614
            |:..:    ||   ||.||:|:..:..|||.||:....|.|:|: .|:|.||||:.:||.::.|:
  Rat   462 GKPKK----YQ---GFSIDVLDALSNYLGFNYEIYVAPDHKYGSPQEDGTWNGLVGELVFKRADI 519

  Fly   615 VLTSLMINTEREAVVDFSEPFMETGIAIVVAKRTGIISPTAFLEPFDTASW-------MLVGIVA 672
            .:::|.|..:||.||||:..:|:..:.:::.:....:...|.|.|||.:.|       :|||:  
  Rat   520 GISALTITPDRENVVDFTTRYMDYSVGVLLRRAEKTVDMFACLAPFDLSLWACIAGTVLLVGL-- 582

  Fly   673 IQAATFMIFLFEWLSPSGYDMKLYLQNTNVTPYRFSLFRTYWLVWAVLFQAAVHVDSPRGFTSRF 737
                  :::|..||:|....|......|        |:.:.|.|:....|....|.... ..:|.
  Rat   583 ------LVYLLNWLNPPRLQMGSMTSTT--------LYNSMWFVYGSFVQQGGEVPYTT-LATRM 632

  Fly   738 MTNVWALFAVVFLAIYTANLAAFM-ITREEFHEFSGLNDSRLVHPFSHKPSFKFGTIPYSHTDST 801
            |...|.|||::.::.||||||||: |||.| .....|.|      .|.:....:||:    .||.
  Rat   633 MMGAWWLFALIVISSYTANLAAFLTITRIE-SSIQSLQD------LSKQTDIPYGTV----LDSA 686

  Fly   802 IHKYFNV----------MHNYM-RQYNKTSVAD--------GVAAVLNGNLDSFIYDGTVLDYLV 847
            ::::..:          |::.| |..|:::.::        |:..|..||. :|::|..||:|:.
  Rat   687 VYQHVRMKGLNPFERDSMYSQMWRMINRSNGSENNVLESQAGIQKVKYGNY-AFVWDAAVLEYVA 750

  Fly   848 AQDEDCRLMTVGSWYAMTGYGLAFSRNSKYVQMFNKRLLEFRANGDLERLRRYW--MTGTCR--- 907
            ..|.||...|||:..|..|||:|....|.|..:|::|:||.:.:||::.|:..|  ..|.|.   
  Rat   751 INDPDCSFYTVGNTVADRGYGIALQHGSPYRDVFSQRILELQQSGDMDILKHKWWPKNGQCDLYS 815

  Fly   908 --PGKQEHKSSDPLALEQFLSAFLLLMAGILLAALLLLLEHVYFKYIRKRLAKKD 960
              ..||:..:.|   ::.....|.:|.|||:|:.|:.:||..:.:....|:..|:
  Rat   816 SVDAKQKGGALD---IKSLAGVFCILAAGIVLSCLIAVLETWWSRRKGSRVPSKE 867

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nmdar2NP_001014714.1 PBP1_iGluR_NMDA_NR2 99..490 CDD:107373 85/441 (19%)
PBP2_iGluR_NMDA_Nr2 502..908 CDD:270436 127/453 (28%)
Lig_chan 665..928 CDD:278489 79/296 (27%)
Grid2NP_077355.2 Interaction with CBLN1 homotrimer. /evidence=ECO:0000250|UniProtKB:O43424 24..345 65/347 (19%)
Periplasmic_Binding_Protein_type1 28..429 CDD:415822 88/479 (18%)
PBP2_iGluR_delta_2 440..806 CDD:270449 119/401 (30%)
Interaction with AP4M1. /evidence=ECO:0000269|PubMed:14572453 921..991
PDZ-binding. /evidence=ECO:0000250 1005..1007
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166349998
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1052
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.740

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