Protein Alignment Nmdar2 and grin1

DIOPT Version :9

• Sequence 1: NP_001014714.1
• Gene: Nmdar2 / 31107
• FlyBaseID: FBgn0053513
• Length: 1083
• Species: Drosophila melanogaster
• Sequence 2: XP_012825220.1
• Gene: grin1 / 780048
• XenbaseID: XB-GENE-494200
• Length: 941
• Species: Xenopus tropicalis
• Alignment Length: 1048
• Identity: 263/1048 - (25%)
• Similarity: 438/1048 - (41%)
• Gaps: 214/1048 - (20%)

  Fly    58 GPISLLLLTVLTLLILDTRSCQGLRLTNGGGSLSKGAAANKEQLNIGLIAPHTNFGKREYLRSIN 122
            |.:.|.||.||.|.......|                  :.:.:|||.:     ...:::.:...
 Frog     2 GTMRLFLLAVLFLFSFARAGC------------------DPKIVNIGAV-----LSTKKHEQIFR 43

  Fly   123 NAVTGLTKTRGAKLTFLKDYSFEQKNIHFDMMSLTPSPTAILSTL--CKEFLRVNVSAILYMMNN 185
            .||....|..|.            ..|..:..|:|..|.||...|  |::.:...|.|||.....
 Frog    44 EAVNQANKRHGT------------WKIQLNATSVTHRPNAIQMALSVCEDLISSQVYAILVSHPP 96

  Fly   186 EQFGHSTASAQYFLQLAGYLGIPVISWNADNSGLERRA---SQSTLQ---LQLAPSIEHQSAAML 244
            ....|.|.:...:  .||:..||||       ||..|.   |..::.   |:..|...||:....
 Frog    97 APTDHLTPTPISY--TAGFYRIPVI-------GLTTRMSIYSDKSIHLSFLRTVPPYSHQALVWF 152

  Fly   245 SILERYKWHQFSVVTSQIAGHDDF--------VQAVRERVAEMQEHFKFTILNSI---------- 291
            .::..:.|:...::.|     ||.        ::.:.|......:...:..|:.:
 Frog   153 EMMRLFNWNHVILIVS-----DDHEGRAAQKKLETLLEEKESKSKKRNYENLDQLSYDNKRGPKA 212

  Fly   292 ---------VVTRTSDLMELVNSEARVMLLYATQTEAITILRAAEEMKLTGENYVWVVSQSVIEK 347
                     ....|:.|:|....||||::|.|::.:|..:.::|..:.:||..|||:|.:..| .
 Frog   213 DKVLQFEPGTKNLTALLLEAKELEARVIILSASEDDATAVYKSAAMLDMTGAGYVWLVGEREI-S 276

  Fly   348 KDAHSQFPVGMLGVHFDTSSAALMN------EISNAIKIYSYGVEAY-----LTDPANRDRRLTT 401
            ..|....|.|::|:.       |:|      .||:|:.:.:..:...     :|||..
 Frog   277 GSALRYAPDGIIGLQ-------LINGKNESAHISDAVAVAAQAIHELFEMENITDPPR------- 327

  Fly   402 QSLSCEDEGRGRWDNGEIFFKYLRNVSIEGDLNKPNIEFTADGDLRSAELKIMNLRPSANNKNLV 466
               .|.. ....|..|.:|.:.|.: |...|.....|||..|||.:.|...||||:    |:.||
 Frog   328 ---GCVG-NTNIWKTGPLFKRVLMS-SKYPDGVTGRIEFNEDGDRKFANYSIMNLQ----NRKLV 383

  Fly   467 WEEIGVWKSWETQKLDIRDIAWPGNSHAPPQGVPEKFHLKITFLEEAPYINLSPADPVSGKCLMD 531
              ::|::......:.| |.|.|||.....|||......|||..:.:.|::.:.|. ...|.|..:
 Frog   384 --QVGIFNGSHVIQND-RKIIWPGGETERPQGYQMSTRLKIVTIHQEPFVYVKPT-MTDGTCREE 444

  Fly   532 --------RGVLCRVAADHEMAADIDVGQAHRNESF------YQCCSGFCIDLLEKFAEELGFTY 582
                    :.|:|.                ..||:.      .|||.|||||||.|.|.|:.|||
 Frog   445 YTINGDPIKKVICN----------------GPNETIPGRPTVPQCCYGFCIDLLIKLAREMNFTY 493

  Fly   583 ELVRVEDGKWGTLE-----NGK-WNGLIADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGIA 641
            |:..|.|||:||.|     |.| |||::.:|::.:.||::..|.||.||...::||:||...|:.
 Frog   494 EVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLT 558

  Fly   642 IVVAKRTGIISPTAFLEPFDTASWMLVGIVAIQAATFMIFLFEWLSPSGYDMKLYLQNTNVTPYR 706
            |:|.|.....:..:|::||.:..|:|||: ::.....|::|.:..||.|   :..:.:.......
 Frog   559 ILVKKEIPRSTLDSFMQPFQSTLWLLVGL-SVHVVAVMLYLLDRFSPFG---RFKVNSEEEEEDA 619

  Fly   707 FSLFRTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAAFMITREEFHEFS 771
            .:|....|..|.||..:.:...:||.|::|.:..|||.||::.:|.||||||||::........:
 Frog   620 LTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERIT 684

  Fly   772 GLNDSRLVHPFSHKPSFKFGTIPYSHTDSTIHKYF------NVMHNYMRQYNKTSVADGVAAVLN 830
            |:||.||.:|   ...|.:.|:..|..|.    ||      :.|:.:|.::|..|.|:.:.||.:
 Frog   685 GINDPRLRNP---SDKFIYATVKQSSVDI----YFRRQVELSTMYRHMEKHNYESAAEAIQAVRD 742

  Fly   831 GNLDSFIYDGTVLDYLVAQDEDCRLMTVGSWYAMTGYGLAFSRNSKYVQMFNKRLLEFRANGDLE 895
            ..|.:||:|..||::..:|  .|.|:|.|..:..:|:|:...::|.:.|..:..:|:...||.:|
 Frog   743 NKLHAFIWDSAVLEFEASQ--KCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLNILKSHENGFME 805

  Fly   896 RLRRYWMTGTCRPGKQEHKSSDP--LALEQFLSAFLLLMAGILLAALLLLLEHVYFKY------- 951
            .|.:.|:    |..:.:.:|:.|  |..|.....|:|:..||:....|:.:|..|.::
 Frog   806 ELDKTWV----RYQECDSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRHKDARRKQ 866

  Fly   952 ----------IRKRLAKKDGGHC-------------CALISLSMGKSLTFRGAVFEATEILKKHR 993
                      .||.|..:..|..             .:.::.|..:..:.:...:..|:|..:..
 Frog   867 MQLAFAAVNVWRKNLQDRKSGRAEPDPKKKASFRSITSTLASSFKRRRSSKDTQYHPTDITGQLN 931

  Fly   994 CNDPICDT 1001
            .:||...|
 Frog   932 LSDPSVST 939

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	97/436 (22%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	131/431 (30%)
		Lig_chan	665..928	CDD:278489	77/270 (29%)
grin1	XP_012825220.1	PBP1_iGluR_NMDA_NR1	25..404	CDD:380602	97/436 (22%)
		PBP2_iGluR_NMDA_Nr1	416..818	CDD:270437	132/435 (30%)
		Ion_trans_2	<620..675	CDD:369572	23/54 (43%)
		CaM_bdg_C0	854..882	CDD:371136	3/27 (11%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000