Protein Alignment Nmdar2 and grin1a

DIOPT Version :10

• Sequence 1: NP_001014714.1
• Gene: Nmdar2 / 31107
• FlyBaseID: FBgn0053513
• Length: 1083
• Species: Drosophila melanogaster
• Sequence 2: XP_073791110.1
• Gene: grin1a / 767745
• ZFINID: ZDB-GENE-051202-1
• Length: 966
• Species: Danio rerio
• Alignment Length: 955
• Identity: 255/955 - (26%)
• Similarity: 424/955 - (44%)
• Gaps: 166/955 - (17%)

  Fly    62 LLLLTVLTLLILDTRSCQGLRLTNGGGSLSKGAAANKEQLNIGLIAPHTNFGKREYLRSINNAVT 126
            ||||..|.       ||..:|    ||       ...:.:|||.:     ..::.|.:...:|||
Zfish     3 LLLLAALF-------SCSCVR----GG-------CEPKIVNIGAV-----LSQKRYEQVFKDAVT 44

  Fly   127 GLTKTRGA---KLTFLKDYSFEQKNIHFDMMSLTPSPTAILSTL--CKEFLRVNVSAILYMMNNE 186
            ...:..|.   |||               .:|:|....||...|  |::.:...|.|||.....:
Zfish    45 QANQVYGRDKFKLT---------------AISVTHKANAIQMALSVCEDLISSQVYAILVSHPPQ 94

  Fly   187 QFGHSTASAQYFLQLAGYLGIPVISWNADNSGLERRA---SQSTLQ---LQLAPSIEHQSAAMLS 245
            ...|.|.:...:  .||:..|||:       ||..|.   |..::.   |:..|...||:.....
Zfish    95 SNDHLTPTPVSY--TAGFYRIPVV-------GLTTRMSIYSDKSIHLSFLRTVPPYSHQAHVWFD 150

  Fly   246 ILERYKWHQFSVVTSQIAGHDDFVQAVRERVA---------------EMQEHFKF---------T 286
            ::..::|:...::.|.    |...:|.::|:.               |.|:...:         .
Zfish   151 MMREFRWNHIILIVSD----DHEGRAAQKRLETLLEERETKNKKRNYENQDQLSYDNKRGPKAEK 211

  Fly   287 ILNSIVVTR-TSDLMELVNSEARVMLLYATQTEAITILRAAEEMKLTGENYVWVVSQSVIEKKDA 350
            :|.....|. |:.|:|....||||::|.|::.:|..:.:.|..:.:||..|||:|.:..:..| |
Zfish   212 VLQFNQETNLTALLLEAKELEARVIILSASEEDAAAVYKTARFLNMTGSGYVWLVGEREMSGK-A 275

  Fly   351 HSQFPVGMLGVHFDTSSAALMN------EISNAIKIYSYGVEAYLTDPANRDRRLTTQSLSCEDE 409
            .|:.|.|::|:.       |:|      .||:|:.:.:..::. |.:..|    :|.....|..
Zfish   276 LSEAPDGLIGLQ-------LINGKNESAHISDAVAVVAQSIQE-LFEKEN----ITEPPRGCVG- 327

  Fly   410 GRGRWDNGEIFFKYLRNVSIEGDLNKPNIEFTADGDLRSAELKIMNLRPSANNKNLVWEEIGVWK 474
            ....|..|.:|.:.|.:......|. ..:||..|||.:.|...|:|.:.|    .|:  ::|::.
Zfish   328 NTNIWKTGPLFKRVLMSSKYPEGLT-GRVEFNDDGDRKYAHYSILNYQKS----RLI--QVGIYN 385

  Fly   475 SWETQKLDIRDIAWPGNSHAPPQGVPEKFHLKITFLEEAPYINLSPADPVSGKCLMD---RGVLC 536
            ..:......|.|.|||.....|:|......|||..:.:.|::.:.|. .:.|.|..:   .|||.
Zfish   386 GTQVVMNKQRKIIWPGGETERPRGFQMSTRLKIVTIHQEPFVYVKPT-TLEGTCKEEYTPNGVLI 449

  Fly   537 RVAADHEMAADIDVGQAHRNESF------YQCCSGFCIDLLEKFAEELGFTYELVRVEDGKWGTL 595
            :..        |..|.   ||:.      .|||.|||||||.|.|..:.||||:..|.|||:||.
Zfish   450 KKV--------ICTGP---NETIPGRPIVPQCCYGFCIDLLIKLALTMNFTYEVHLVADGKFGTQ 503

  Fly   596 E-----NGK-WNGLIADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGIAIVVAKRTGIISPT 654
            |     |.| |||::.:|:....||::..|.||.||...::||:||...|:.|:|.|.....:..
Zfish   504 ERVNNSNKKEWNGMMGELLGGLADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRSTLD 568

  Fly   655 AFLEPFDTASWMLVGIVAIQAATFMIFLFEWLSPSGYDMKLYLQNTNVTPYRFSLFRTYWLVWAV 719
            :|::||.:..|:|||: ::.....|::|.:..||.|   :..:.:........:|....|..|.|
Zfish   569 SFMQPFQSTLWLLVGL-SVHVVAVMLYLLDRFSPFG---RFKVNSEEEEEDALTLSSAMWFSWGV 629

  Fly   720 LFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAAFMITREEFHEFSGLNDSRLVHPFSH 784
            |..:.:...:||.|::|.:..|||.||::.:|.||||||||::........:|:||.||.:|
Zfish   630 LLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNP--- 691

  Fly   785 KPSFKFGTIPYSHTDSTIHKYF------NVMHNYMRQYNKTSVADGVAAVLNGNLDSFIYDGTVL 843
            ...|.:.|:..|..|.    ||      :.|:.:|.::|..|.|:.:.||.:..|.:||:|..||
Zfish   692 SDKFIYATVKQSSVDI----YFRRQVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVL 752

  Fly   844 DYLVAQDEDCRLMTVGSWYAMTGYGLAFSRNSKYVQMFNKRLLEFRANGDLERLRRYWMTGTCRP 908
            ::..:|  .|.|:|.|..:..:|:|:...::|.:.|..:..:|....||.:|.|.:.|:    |.
Zfish   753 EFEASQ--KCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLAILSSHENGFMEDLDKTWV----RY 811

  Fly   909 GKQEHKSSDP--LALEQFLSAFLLLMAGILLAALLLLLEHVYFKY 951
            .:.:.:|:.|  |..|.....|:|:..||.....|:.:|..|.::
Zfish   812 QECDSRSNAPATLTFENMAGVFMLVAGGIAAGIFLIFIEIAYKRH 856

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..485	CDD:380601	93/427 (22%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	133/426 (31%)
grin1a	XP_073791110.1	None