Protein Alignment Nmdar2 and grin1a

DIOPT Version :9

• Sequence 1: NP_001014714.1
• Gene: Nmdar2 / 31107
• FlyBaseID: FBgn0053513
• Length: 1083
• Species: Drosophila melanogaster
• Sequence 2: XP_005161118.1
• Gene: grin1a / 767745
• ZFINID: ZDB-GENE-051202-1
• Length: 951
• Species: Danio rerio
• Alignment Length: 954
• Identity: 252/954 - (26%)
• Similarity: 423/954 - (44%)
• Gaps: 160/954 - (16%)

  Fly    62 LLLLTVLTLLILDTRSCQGLRLTNGGGSLSKGAAANKEQLNIGLIAPHTNFGKREYLRSINNAVT 126
            ||||..|.       ||..:|    ||       ...:.:|||.:     ..::.|.:...:|||
Zfish     3 LLLLAALF-------SCSCVR----GG-------CEPKIVNIGAV-----LSQKRYEQVFKDAVT 44

  Fly   127 GLTKTRGA---KLTFLKDYSFEQKNIHFDMMSLTPSPTAILSTL--CKEFLRVNVSAILYMMNNE 186
            ...:..|.   |||               .:|:|....||...|  |::.:...|.|||.....:
Zfish    45 QANQVYGRDKFKLT---------------AISVTHKANAIQMALSVCEDLISSQVYAILVSHPPQ 94

  Fly   187 QFGHSTASAQYFLQLAGYLGIPVISWNADNSGLERRA---SQSTLQ---LQLAPSIEHQSAAMLS 245
            ...|.|.:...:  .||:..|||:       ||..|.   |..::.   |:..|...||:.....
Zfish    95 SNDHLTPTPVSY--TAGFYRIPVV-------GLTTRMSIYSDKSIHLSFLRTVPPYSHQAHVWFD 150

  Fly   246 ILERYKWHQFSVVTSQIAGHDDFVQAVRERVA---------------EMQEHFKF---------T 286
            ::..::|:...::.|.    |...:|.::|:.               |.|:...:         .
Zfish   151 MMREFRWNHIILIVSD----DHEGRAAQKRLETLLEERETKNKKRNYENQDQLSYDNKRGPKAEK 211

  Fly   287 ILNSIVVTR-TSDLMELVNSEARVMLLYATQTEAITILRAAEEMKLTGENYVWVVSQSVIEKKDA 350
            :|.....|. |:.|:|....||||::|.|::.:|..:.:.|..:.:||..|||:|.:..:..| |
Zfish   212 VLQFNQETNLTALLLEAKELEARVIILSASEEDAAAVYKTARFLNMTGSGYVWLVGEREMSGK-A 275

  Fly   351 HSQFPVGMLGVHFDTSSAALMN------EISNAIKIYSYGVEAYLTDPANRDRRLTTQSLSCEDE 409
            .|:.|.|::|:.       |:|      .||:|:.:.:..::. |.:..|    :|.....|..
Zfish   276 LSEAPDGLIGLQ-------LINGKNESAHISDAVAVVAQSIQE-LFEKEN----ITEPPRGCVG- 327

  Fly   410 GRGRWDNGEIFFKYLRNVSIEGDLNKPNIEFTADGDLRSAELKIMNLRPSANNKNLVWEEIGVWK 474
            ....|..|.:|.:.|.:......|. ..:||..|||.:.|...|:|.:.|    .|:  ::|::.
Zfish   328 NTNIWKTGPLFKRVLMSSKYPEGLT-GRVEFNDDGDRKYAHYSILNYQKS----RLI--QVGIYN 385

  Fly   475 SWETQKLDIRDIAWPGNSHAPPQGVPEKFHLKITFLEEAPYINLSPADPVSGKC--------LMD 531
            ..:......|.|.|||.....|:|......|||..:.:.|::.:.|. .:.|.|        ::.
Zfish   386 GTQVVMNKQRKIIWPGGETERPRGFQMSTRLKIVTIHQEPFVYVKPT-TLEGTCKEEYTPNGVLI 449

  Fly   532 RGVLCRVAADHEMAADIDVGQAHRNESFYQCCSGFCIDLLEKFAEELGFTYELVRVEDGKWGTLE 596
            :.|:|  ...:|...    |.........|||.|||||||.|.|..:.||||:..|.|||:||.|
Zfish   450 KKVIC--TGPNETIP----GNTSGRPIVPQCCYGFCIDLLIKLALTMNFTYEVHLVADGKFGTQE 508

  Fly   597 -----NGK-WNGLIADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGIAIVVAKRTGIISPTA 655
                 |.| |||::.:|:....||::..|.||.||...::||:||...|:.|:|.|.....:..:
Zfish   509 RVNNSNKKEWNGMMGELLGGLADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRSTLDS 573

  Fly   656 FLEPFDTASWMLVGIVAIQAATFMIFLFEWLSPSGYDMKLYLQNTNVTPYRFSLFRTYWLVWAVL 720
            |::||.:..|:|||: ::.....|::|.:..||.|   :..:.:........:|....|..|.||
Zfish   574 FMQPFQSTLWLLVGL-SVHVVAVMLYLLDRFSPFG---RFKVNSEEEEEDALTLSSAMWFSWGVL 634

  Fly   721 FQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAAFMITREEFHEFSGLNDSRLVHPFSHK 785
            ..:.:...:||.|::|.:..|||.||::.:|.||||||||::........:|:||.||.:|   .
Zfish   635 LNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNP---S 696

  Fly   786 PSFKFGTIPYSHTDSTIHKYF------NVMHNYMRQYNKTSVADGVAAVLNGNLDSFIYDGTVLD 844
            ..|.:.|:..|..|.    ||      :.|:.:|.::|..|.|:.:.||.:..|.:||:|..||:
Zfish   697 DKFIYATVKQSSVDI----YFRRQVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLE 757

  Fly   845 YLVAQDEDCRLMTVGSWYAMTGYGLAFSRNSKYVQMFNKRLLEFRANGDLERLRRYWMTGTCRPG 909
            :..:|  .|.|:|.|..:..:|:|:...::|.:.|..:..:|....||.:|.|.:.|:    |..
Zfish   758 FEASQ--KCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLAILSSHENGFMEDLDKTWV----RYQ 816

  Fly   910 KQEHKSSDP--LALEQFLSAFLLLMAGILLAALLLLLEHVYFKY 951
            :.:.:|:.|  |..|.....|:|:..||.....|:.:|..|.::
Zfish   817 ECDSRSNAPATLTFENMAGVFMLVAGGIAAGIFLIFIEIAYKRH 860

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	96/432 (22%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	130/425 (31%)
		Lig_chan	665..928	CDD:278489	77/270 (29%)
grin1a	XP_005161118.1	PBP1_iGluR_NMDA_NR1	5..401	CDD:107374	104/467 (22%)
		ANF_receptor	54..372	CDD:279440	81/360 (23%)
		PBP2_iGluR_NMDA_Nr1	413..819	CDD:270437	131/429 (31%)
		Lig_chan	581..844	CDD:278489	79/279 (28%)
		CaM_bdg_C0	855..883	CDD:287524	1/6 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910