DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nmdar2 and si:ch211-251b21.1

DIOPT Version :9

Sequence 1:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster
Sequence 2:	NP_001138274.1	Gene:	si:ch211-251b21.1 / 571720	ZFINID:	ZDB-GENE-060809-5	Length:	458	Species:	Danio rerio

Alignment Length:	510	Identity:	135/510 - (26%)
Similarity:	228/510 - (44%)	Gaps:	98/510 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   505 LKITFLEEAPYINLSPADPVSGKCLMDRGVLCRVAADHEMAADIDVGQAHRNESFYQCCSGFCID 569
            ||:|.::|.||             .|.:|            ::::               |||||
Zfish    25 LKVTTIKEEPY-------------AMSKG------------SELE---------------GFCID 49

  Fly   570 LLEKFAEELGFTYELVRVEDGKWG-TLENGKWNGLIADLVNRKTDMVLTSLMINTEREAVVDFSE 633
            :|...:.:|||.|::..|:||::| |.::|.|||:|.::|..:.|:.:..|.:..:||||||.|:
Zfish    50 MLSAISNKLGFKYDVHLVKDGRYGKTDDSGNWNGMIGEVVRGEADIAVAPLTLTAQREAVVDMSK 114

  Fly   634 PFMETGIAIVVAKRTGIISP--TAFLEPFDTASWMLVGIVAIQAATFMIFLFEWLSPSGYDMKLY 696
            |||:||::.::.|..|....  .:.|:.|.|..||.| :||....:..|||...:||..::....
Zfish   115 PFMQTGLSFIMRKDLGSDDSQFLSLLKLFSTEMWMGV-LVAYLLTSICIFLVSRISPCEWEQPEK 178

  Fly   697 LQNTNVTPYRFSLFRTYW-LVWAVLFQ-AAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAA 759
            ..|:      |:|..::| .|.|:..| |..|   |:..:.|.:|::|.:|::|.||.|.|||:.
Zfish   179 DNNS------FTLSHSFWYTVGALTLQGAGPH---PKALSGRVITSIWWIFSLVLLACYFANLSL 234

  Fly   760 FM------ITREEFHEFSGLNDSRLVHPFSHKPSFKFGTIPYSHTDSTIHKYFNVMHN--YMRQY 816
            ::      ::.:.|.:.:..|            ..::|||    .||:...:|...:|  |.|.|
Zfish   235 WLHSDNQQLSIKTFEDLANQN------------VIEYGTI----KDSSSFNFFKNSNNPTYHRIY 283

  Fly   817 N--------KTSVADGVAAVLNGNLDSFIYDGTVLDYLVAQDEDCRLMTVGSWYAMTGYGLAFSR 873
            .        ..:.|:|......||. :||.:...||..||:  .|.|........|.||.:|...
Zfish   284 EHIKEAQSYSLNAAEGFRRAQKGNY-AFIGESVSLDLAVAR--YCNLTRAPEIIGMRGYSIAAPL 345

  Fly   874 NSKYVQMFNKRLLEFRANGDLERLRRYWMTGTCRPGKQEHKSSDPLALEQFLSAFLLLMAGILLA 938
            .|..::..:..:|....:|:|:..|..|...:|   ..:.....||........||||..|:.|.
Zfish   346 GSPLIKNLSVAILRLSESGELDYFRSKWWASSC---VAKDSKGAPLKPASLKGVFLLLAFGLGLG 407

  Fly   939 ALLLLLEHVYFKYIRKRLAKKDGGHCCALISLSMGKSLTFRGAVFEATEILKKHR 993
            ..|.|:|   .....:::|..:...||:::|..:  |..|||......|..:|::
Zfish   408 IFLALME---LAAKSRKVANSEQKSCCSVMSAEL--SQRFRGGEVATPESSEKNK 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	114/423 (27%)
		Lig_chan	665..928	CDD:278489	68/280 (24%)
si:ch211-251b21.1	NP_001138274.1	PBP2_iGluR_non_NMDA_like	25..375	CDD:270403	113/418 (27%)
si:ch211-251b21.1	NP_001138274.1	Lig_chan	146..396	CDD:278489	68/281 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900