DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar2 and grin2ab

DIOPT Version :9

Sequence 1:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster
Sequence 2:	XP_009304490.1	Gene:	grin2ab / 570493	ZFINID:	ZDB-GENE-070424-223	Length:	1445	Species:	Danio rerio

Alignment Length:	922	Identity:	287/922 - (31%)
Similarity:	466/922 - (50%)	Gaps:	95/922 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 PTAILSTLCKEFLRVNVSAILYMMNNEQFGHSTASAQYFLQLAGYLGIPVISWNADNSGLERRAS 224
            |.::|:.||:...|..:..::|....:|    .|.||....::....:|::..:..::.......
Zfish    68 PGSMLTHLCELMSRQRLHGLVYGDGTDQ----EAVAQMLDFVSSQTSMPILGIHGGSAMTMAEKD 128

  Fly   225 QSTLQLQLAPSIEHQSAAMLSILERYKWHQFSVVTSQIAGHDDFVQAVRERVAEMQEH-FKFTIL 288
            .|:...|...|::.::..||:|:|.|.||.|||||::..|..:|:..||..|    :| |....|
Zfish   129 SSSSFFQFGASLQQEALLMLAIMEEYDWHVFSVVTTKFPGFQEFIATVRVTV----DHSFVRWDL 189

  Fly   289 NSIV----VTRTSDL--MELVNSEARVMLLYATQTEAITILRAAEEMKLTGENYVWVV-SQSVIE 346
            .|:|    |....|.  ::|...::.|:|||.::.||..::..|..:.|||..:||:| |.:...
Zfish   190 QSVVTLDGVGEPEDRAHVQLKRIQSPVILLYCSKDEAALVMEEARSLGLTGAGFVWIVPSLTTGN 254

  Fly   347 KKDAHSQFPVGMLGVHFDTSSAALMNEISNAIKIYSYGVEAYLTDPANRDRRLTTQSLSCEDEGR 411
            .:.....||.||:.|.:|.....|...:.:|:.|.|....|...:    :.|:...:.||    .
Zfish   255 LEHIPEAFPAGMISVTYDEWDYPLETRLQDAVGIISSAAAAMFRE----EGRIPDGTASC----Y 311

  Fly   412 GRWDNGEIFFKYLRNVSIEGDLNKPNIEFTADGDLRSAELKIMNLRPSANNKNLVWEEIGVWKSW 476
            |:.:..|:....||...:..:|...:..|..||...:.:|.::.|     |....||::|   .|
Zfish   312 GQSEKPEVPPSALRRYMMGVNLGGKDHSFMDDGYQVNPKLVVIVL-----NTEREWEKMG---RW 368

  Fly   477 ETQKLDIRDIAWP-----GNSHAPPQGVPEKFHLKITFLEEAPYINLSPADPVSGKCLMDRGVLC 536
            |...|.::...||     |:..|      ::.||.|..|||.|::.:...|.::|.| |...|.|
Zfish   369 ENHSLRLKFPVWPRYNSFGDMDA------DENHLSIVTLEERPFVIVDDVDILTGTC-MRNSVPC 426

  Fly   537 RVAADHEMAADIDVGQAHRNESFY--QCCSGFCIDLLEKFAEELGFTYELVRVEDGKWGTLENGK 599
            |...           :.:..|..|  :||.|||||:|:|.|..:.|||:|..|.:||.|...|..
Zfish   427 RKHI-----------KDNTTEGSYVKKCCKGFCIDILKKIARNVKFTYDLYLVTNGKHGKKINNV 480

  Fly   600 WNGLIADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGIAIVVAKRTGIISPTAFLEPFDTAS 664
            |||::.::|.:|..|.:.||.||.||...:|||.||:||||:::|::..|.:||:||||||..:.
Zfish   481 WNGMVGEVVYKKAVMAVGSLTINEERSEAIDFSVPFVETGISVMVSRSNGTVSPSAFLEPFSASV 545

  Fly   665 WMLVGIVAIQAATFMIFLFEWLSPSGYDMKLYLQNTNVTPYRFSLFRTYWLVWAVLFQAAVHVDS 729
            |:::.::.:......:||||::||.|::..| .|..:.....|::.:..||:|.::|..:|.|.:
Zfish   546 WVMMFVMLLIVTAIAVFLFEFISPLGFNRNL-AQGKDPHGPSFTIGKAVWLLWGLVFNNSVPVQN 609

  Fly   730 PRGFTSRFMTNVWALFAVVFLAIYTANLAAFMITREEFHEFSGLNDSRLVHPFSHKPSFKFGTIP 794
            |||.||:|:.:|||.|||:|||.||||||||||..|...:.:||:|.:...|:|:.|.|:|||:|
Zfish   610 PRGTTSKFIVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDRKFQSPYSYSPPFRFGTVP 674

  Fly   795 YSHTDSTIHKYFNVMHNYMRQYNKTSVADGVAAVLNGNLDSFIYDGTVLDYLVAQDEDCRLMTVG 859
            ...|:..|.|.:..||.||.:|::|.|.|.:.::..|.||:||||..||:|:..:|:.|:|:|:|
Zfish   675 NGSTERNIRKNYPAMHQYMVKYHQTGVVDALVSLKTGKLDAFIYDAAVLNYMAGRDDGCKLVTIG 739

  Fly   860 SWY--AMTGYGLAFSRNSKYVQMFNKRLLEFRANGDLERLRRYWMTGTCRPGKQEHKSSDPLALE 922
            |.|  |.||||:|..:.|.:.::.:..:|....:|::|.|...|:||.|...|.|..||. |.::
Zfish   740 SGYIFATTGYGIAMQKGSYWKRLVDLAILGIIGDGEMEELEAQWLTGICHNEKNEVMSSQ-LDVD 803

  Fly   923 QFLSAFLLLMAGILLAALLLLLEHVYFKYIRKRLAKKDGGHCCALISLSMGKSLTFRGAVFEATE 987
            .....|.:|.|.:.|:.:..:.||:::..:|........|....|.::|.|......|...|
Zfish   804 NMAGVFYMLAAAMALSLITFVWEHLFYWRLRYCFTGLCSGRPGILFTISRGIWSCIHGVHIE--- 865

  Fly   988 ILKKHRCNDPICDTHLWKVKHELDMS----RLRVRQLEKVMDKHGIKAPQLRLASSSDLLNHHHL 1048
             |||               ..|||.|    .|.:.:..|.:...|:.:|:..::|   :|
Zfish   866 -LKK---------------APELDFSPQANMLHLLKSAKEITTLGVTSPKRPMSS---IL----- 906

  Fly  1049 KERPPLLGNLSL 1060
               ||..|.|.|
Zfish   907 ---PPTSGLLEL 915

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	86/342 (25%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	163/409 (40%)
		Lig_chan	665..928	CDD:278489	102/264 (39%)
grin2ab	XP_009304490.1	PBP1_iGluR_NMDA_NR2	25..382	CDD:107373	85/337 (25%)
		ANF_receptor	48..358	CDD:279440	77/310 (25%)
		PBP2_iGluR_NMDA_Nr2	393..790	CDD:270436	163/409 (40%)
		Lig_chan	544..816	CDD:278489	105/273 (38%)
		NMDAR2_C	827..1445	CDD:287527	26/119 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591464
Domainoid	1	1.000	218	1.000	Domainoid score	I2585
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	438	1.000	Inparanoid score	I1644
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D279143at33208
OrthoFinder	1	1.000	-	-		FOG0000775
OrthoInspector	1	1.000	-	-		otm24466
orthoMCL	1	0.900	-	-		OOG6_102799
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.900