DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar2 and grin3ba

DIOPT Version :9

Sequence 1:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster
Sequence 2:	XP_021323058.1	Gene:	grin3ba / 566411	ZFINID:	ZDB-GENE-070912-354	Length:	1118	Species:	Danio rerio

Alignment Length:	1070	Identity:	269/1070 - (25%)
Similarity:	465/1070 - (43%)	Gaps:	214/1070 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 LNIGLIAPHTNFGKREYLR---SINNAVTGLTKTRGAKLTFLKDYSFEQKNIHFDMMSLTP---S 159
            :.:|.:.|     .|:..|   ::|.|:..|.::..         :|...|:..:::|..|   .
Zfish    44 VRLGALLP-----TRQQSRIQGALNRALVHLRQSGN---------NFLPYNLSLEVLSREPLNGD 94

  Fly   160 PTAILSTLCKEFLRVNVSAIL-YMMNNEQFGHSTASAQYFLQ---LAGYLGIPVISWNADNSGLE 220
            |.::...:|::.:...|||:| :..::|:          .:|   ::.:|.||.||.......|:
Zfish    95 PESMFRCVCQDIVVQGVSAVLAFPQSHEE----------LIQVEFMSSFLEIPFISIIEQGEPLK 149

  Fly   221 RRASQSTLQLQLAPSIEHQ--SAAMLSILERYKWHQFSVVTSQIAGHDDFVQAVRER-------- 275
               :|:...||:...:...  |..:|::|.|..|...:.......|:...::.:::|
Zfish   150 ---TQNRFHLQMMTRMPPSGLSDLLLAVLLRGGWQGGAATVCPGGGNTGMLEELQQRGHLGLDGA 211

  Fly   276 ---------VAEMQEHF---KFTILNSIVVTRTSDLMELVNSEARVMLLYATQTE-AITILRAAE 327
                     ::.::|:.   |...|.|.:::||.      ::.|..::|:.:..| ..|:|..|.
Zfish   212 HWHLWETLNLSRLEENISEDKVMELLSQLLSRTP------SAPASSVVLFGSDPECTATVLHCAH 270

  Fly   328 EMKLTGENYVWVVSQSVIEKKDAHSQFPVGMLGVHFDTSSAALM--NEIS-NAIKIY------SY 383
            ::..|.....|::.            :|:.:..:|...|...||  .|:: ..:..|      ..
Zfish   271 QLSGTLPPMHWIMG------------YPLSLDSLHSIGSPLGLMAYGEVNRKPLNFYIRDTLQLI 323

  Fly   384 GVEAYLTDPANRDRRLTTQSLSCEDEGRGRW--DNGEIFFKYLRNVSIEGDLNKPNIEFTADGDL 446
            |...|.......|..|....::|.|:.....  .:|:...::|.|.|..|......:|.:....|
Zfish   324 GRAVYAATMVRPDLALIQNMVNCFDKPNKHELPSSGQYLARFLSNTSFTGLTGPVRVERSFSRVL 388

  Fly   447 RSAELKIMNL------RPSANNKNLVWEEIGVWKSWETQKLDIRDIA-WPG-NSHAPPQGVPEKF 503
            .|....|.:|      :||       |..:.   ||::.:|::.:.. ||| ..|....|...:.
Zfish   389 TSQRFHIWSLQRDPLGQPS-------WVTVA---SWQSGRLELEEQGLWPGVTQHQREDGPGIRL 443

  Fly   504 -------------HLKITFLEEAPYINLSPADPVSGKCLMDRGVLCRVAADHEMAADIDVGQAHR 555
                         .|::..|.|.|::.....|. .|:|  ..|.||   .|.:......:.|..|
Zfish   444 GGRWQAGLPVAGSRLRVVTLVEHPFVFTREVDE-EGQC--PAGQLC---LDPQTNNSEVLNQLFR 502

  Fly   556 -----NES-----FYQCCSGFCIDLLEKFAEELGFTYELVRVEDGKWGTLENGKWNGLIADLVNR 610
                 |.|     ..:||.|:|||||||.||::.|.::|..|.|||:|..:.|:|:||:.||::.
Zfish   503 ELEQTNSSSLPTDMRKCCYGYCIDLLEKLAEDMHFEFDLYIVGDGKYGAWKGGRWSGLVGDLLSG 567

  Fly   611 KTDMVLTSLMINTEREAVVDFSEPFMETGIAIVVAKRTGIISPTAFLEPFDTASWMLVGI-VAIQ 674
            ..||.:||..||:.|..|:||:.||..|.:.|:|..:.......||:.|...:.|  ||| ||:.
Zfish   568 VADMAVTSFSINSARSRVIDFTSPFFSTSLGILVRSKDTAAPIGAFMWPLHWSMW--VGIFVALH 630

  Fly   675 AATFMIFLFEWLSPSGYDMKLYLQNTNVTPYR------FSLFRTYWLVWAVLFQAAVHVDSPRGF 733
            .....|.|:||.||.|           :||:.      ||......|.:|:||...|...:|:.:
Zfish   631 ITALFITLYEWNSPFG-----------MTPHGRNRIRVFSYSSALNLCYAILFGRTVASKTPKCW 684

  Fly   734 TSRFMTNVWALFAVVFLAIYTANLAAFMITREEFHEFSGLNDSRLVHPFSHKPSFKFGTIPYSHT 798
            |.||:.|:||:|.::.|:.|||||||.|:..:.|.|.||::|.:|.||   ...|:|||:..|..
Zfish   685 TGRFLMNLWAIFCLLVLSSYTANLAAVMVGEKTFEEVSGIHDVKLHHP---SLGFRFGTVRESSA 746

  Fly   799 DSTIHKYFNVMHNYMRQYNKTSVADGVAAVLNG--NLDSFIYDGTVLDYLVAQDEDCRLMTVGSW 861
            :..:.|.|..||.|||::||.:..|||:.:...  .||:||.|..:|||.|:.|.||:|:|||..
Zfish   747 EDYVKKSFPEMHEYMRRFNKPTTPDGVSTLKTDPPQLDAFIMDKALLDYEVSIDADCKLLTVGKP 811

  Fly   862 YAMTGYGLAFSRNSKYVQMFNKRLLEFRANGDLERLRRYW-MTGTCRPGKQEHKSSDPL--ALEQ 923
            :|:.|||:...:||...:..::.:..::::|.::.|...| ....|  ||:....::.|  .::.
Zfish   812 FAIEGYGIGLPQNSPLTRNVSEYVSRYKSDGYMDMLHDKWYKVVPC--GKRVFAVTETLQMGIQH 874

  Fly   924 FLSAFLLLMAGILLAALLLLLEHVYFKYIRKRLAKKDGGHCCALISLSMGKSLTFRGAVFEATEI 988
            |...|:||..|:..|.|.||.||.:|::|...|..:.                .|:..:..:.:|
Zfish   875 FSGLFVLLCVGVAGALLTLLGEHAFFRFILPHLRHQQ----------------RFKYWLHTSQKI 923

  Fly   989 LKKHRCNDPICDTHLWKVKHELDMSRLRVRQLEKVMDKHGIKAPQLRLASSSDLLNHHHL---KE 1050
               ||..:..||.   :.|.|.:.|.               :.|.|.|:.:.:|   |.|   ..
Zfish   924 ---HRAINMGCDD---ERKSEAESSD---------------RCPTLCLSENCNL---HRLPPSSS 964

  Fly  1051 RPPLLGNLSLAASAQDLYRWSYKTEIAEME 1080
            .||     |.::::....:|:.::..|..|
Zfish   965 SPP-----STSSTSTTTTKWNNQSVKAGRE 989

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	79/439 (18%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	148/438 (34%)
		Lig_chan	665..928	CDD:278489	94/274 (34%)
grin3ba	XP_021323058.1	Periplasmic_Binding_Protein_Type_1	26..428	CDD:324556	78/438 (18%)
grin3ba	XP_021323058.1	PBP2_iGluR_NMDA_Nr3	457..852	CDD:270438	146/416 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591802
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740