Protein Alignment Nmdar2 and grin3a

DIOPT Version :9

• Sequence 1: NP_001014714.1
• Gene: Nmdar2 / 31107
• FlyBaseID: FBgn0053513
• Length: 1083
• Species: Drosophila melanogaster
• Sequence 2: XP_009303361.1
• Gene: grin3a / 564832
• ZFINID: ZDB-GENE-130530-780
• Length: 1111
• Species: Danio rerio
• Alignment Length: 1088
• Identity: 264/1088 - (24%)
• Similarity: 453/1088 - (41%)
• Gaps: 227/1088 - (20%)

  Fly    79 QGLRLTNGGGSLSKGAAANKEQLNIGLIAPHTNFGKREYLRSINNAVTGLTKTRG---------- 133
            :|:|..:...:|:|   |:|.:..:..:||...|..|:   |:..|...|.:..|
Zfish    97 RGIRTKSSVNNLNK---ASKSKTVLKQVAPDVVFLPRD---SVLLASESLNRVAGLLPYNLTLEI 155

  Fly   134 -----AKLTFLKDYSFEQKNIHFDMMSLTPS---PTAILSTLCKEFLRVNVSAILYMMNNEQFGH 190
                 |.|..|..:||..        |.||:   |.:.|.::|...:...||||:....|..
Zfish   156 VMAVEAGLGELPAFSFSS--------SSTPACADPVSFLQSVCHTVIVQGVSAIISFPQNRD--- 209

  Fly   191 STASAQYFLQLAGYLGIPVISWNADNSGLERRASQSTLQLQLAPSIEHQSAAML--SILERYKWH 253
            .....::   :|..|.|||||  ...|..:|: :|:.|..|:|......|.|.|  |:|....|.
Zfish   210 ELVKLEF---IASTLQIPVIS--VVQSEFQRQ-TQNLLHFQMAMQNPQTSQANLIFSLLSMNNWF 268

  Fly   254 QFSVVTSQIAGHDDFVQAVRERVAEMQEHFKF---TILNSIVVTRTSD----------LMELVNS 305
            ..|:|..|.....|||..       :..:.||   |:|.  :.|.:|.          .:|.:..
Zfish   269 DVSLVMCQQMNISDFVFL-------LHNNSKFHLGTVLK--ISTNSSSKNDFHIFLQAQLESIKD 324

  Fly   306 EARVMLLYATQTEAI-TILRAAEEMKLTGENYVWVV--SQSVIEKKDAHSQFPVGMLGVHFDTSS 367
            ....::.:......| .|.....:..|...:|.|::  ||:|.|.:.  ...|:|:| .|.....
Zfish   325 STSTLVTFGCDIRDIRRIFTTIAKFGLILPDYHWIIGDSQNVEELRT--EGLPMGLL-AHGRMGE 386

  Fly   368 AALMNEISNAIKIYSYGVE---------AYLTDPANRDRRLTTQSLSCEDEGRGRWDNGEIFFKY 423
            .:|.:.:.:|:::.:..|.         |.:....|...||..::|:          :|....:|
Zfish   387 PSLDHYVQDALELVARAVGSAATVSPQLALIPGTTNCLARLEAKNLT----------SGTFLSRY 441

  Fly   424 LRNVSIEGDLNKPNI--EFTADGDLRSAELKIMNLRPSANNKNLVWEEIGVWKSWETQKLDIRDI 486
            :.:.|.:|.....::  |.|.   :..:...|.||:.....|.: |..:|.||..:.    :.|.
Zfish   442 MASTSFDGLSGCISVQEESTI---ISESHHFIWNLQHDPIGKPM-WTRLGSWKHGKV----VMDY 498

  Fly   487 -AWPGNSHAPPQGV----PEKFHLKITFLEEAPYINLSPADPVSGKCLMDRGVLC--RVAADHEM 544
             .||....:.| |.    ..:.||::..|.|.|::.....|. .|.|  ..|.||  .:..|..:
Zfish   499 GVWPNKRRSQP-GADWRHSSRLHLRVVTLVEHPFVFTRDVDD-EGLC--PAGQLCLDPLTNDTAL 559

  Fly   545 AADIDVGQAHRNES----FYQCCSGFCIDLLEKFAEELGFTYELVRVEDGKWGTLENGKWNGLIA 605
            ...:..|....|::    |.:||.|:|||||||.||::||.::|..|.|||:|..:||:|.||:.
Zfish   560 LESLFQGLQGANDTVPLEFKKCCYGYCIDLLEKLAEDMGFDFDLYIVGDGKYGAYKNGRWTGLVG 624

  Fly   606 DLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGIAIVVAKRTGIISPTAFLEPFDTASWMLVGI 670
            ||::....:.:||..||:.|..|:||:.||..|.:.|:|..|.......||:.|...:.|:  ||
Zfish   625 DLMSGAAHLAVTSFSINSARSQVIDFTSPFFSTSLGILVRTRDTAAPIGAFMWPLHWSMWL--GI 687

  Fly   671 -VAIQAATFMIFLFEWLSPSGYDMKLYLQNTNVTPYR------FSLFRTYWLVWAVLFQAAVHVD 728
             |::......:.|:||.||.|           :||..      ||......:.:|:||.....:.
Zfish   688 FVSLHVTAVFLTLYEWKSPFG-----------MTPRGRNRDRVFSFSSALNVCYAILFGRTAAIK 741

  Fly   729 SPRGFTSRFMTNVWALFAVVFLAIYTANLAAFMITREEFHEFSGLNDSRLVHPFSHKPSFKFGTI 793
            .|:.:|.||:.|:||:|.:..|:.|||||||.|:..:.:.:.||::|.:|.||   ...|:|||:
Zfish   742 PPKCWTGRFLMNLWAIFCLFCLSTYTANLAAVMVGEKTYEQLSGIHDPKLHHP---SQGFRFGTV 803

  Fly   794 PYSHTDSTIHKYFNVMHNYMRQYNKTSVADGVAAVLNG--NLDSFIYDGTVLDYLVAQDEDCRLM 856
            ..|..:..:.|.|..||.|||:||..:..||:..:.:.  .||:||.|..:|||....|:....:
Zfish   804 RESSAEDYVKKSFPEMHEYMRRYNAPTTPDGIDHLKDDPQKLDAFIMDKALLDYWAHADKXYISL 868

  Fly   857 TVGSWYAMTGYGLAFSRNSKYVQMFNKRLLEFRANGDLERLRRYW-MTGTCRPGKQEHKSSDPL- 919
                  .:||||:...:||......::.:.:::::|.::.|...| ....|  ||:....::.|
Zfish   869 ------LLTGYGIGLKQNSPLTSNISELVSQYKSDGFMDMLHDKWYKVVPC--GKRSFAVTETLQ 925

  Fly   920 -ALEQFLSAFLLLMAGILLAALLLLLEHVYFKYI------------------------------- 952
             .::.|...|::|..|:.|:.|..|.||:..:::
Zfish   926 MGIKHFSGLFVMLCVGVALSLLTTLGEHIVHRWVIPRMQESTEHKYWLHTSQRLHRALNPTFKED 990

  Fly   953 -------------------------------RKRLAKKDGG------HCCALISLSMGKSLTFRG 980
                                           |::|:.::|.      ||..|:.....:.|..:.
Zfish   991 KLQTVAKPEKSCNVGNNQQMPWNSLGTPNCNRRKLSNQEGQNDLECCHCKELLCPQEKRQLPLQA 1055

  Fly   981 AVFEATEILKKHRCNDPI------CDTHLWKVKHELDMSRLRVRQLEK 1022
            .....|::|  ....:||      .:|.:..:|.:|.::..:.::||:
Zfish  1056 TSNGRTDLL--GLAQNPIVQELTDLETQIQLIKKQLQLAMKKKKELEQ 1101

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	93/438 (21%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	134/421 (32%)
		Lig_chan	665..928	CDD:278489	79/274 (29%)
grin3a	XP_009303361.1	Periplasmic_Binding_Protein_Type_1	36..502	CDD:299141	98/457 (21%)
		ANF_receptor	132..452	CDD:279440	77/358 (22%)
		PBP2_iGluR_NMDA_Nr3	518..908	CDD:270438	132/414 (32%)
		Lig_chan	682..941	CDD:278489	81/282 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591803
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.740