Protein Alignment Nmdar2 and grik1b

DIOPT Version :10

• Sequence 1: NP_001014714.1
• Gene: Nmdar2 / 31107
• FlyBaseID: FBgn0053513
• Length: 1083
• Species: Drosophila melanogaster
• Sequence 2: XP_690040.5
• Gene: grik1b / 561540
• ZFINID: ZDB-GENE-070821-1
• Length: 906
• Species: Danio rerio
• Alignment Length: 992
• Identity: 228/992 - (22%)
• Similarity: 392/992 - (39%)
• Gaps: 216/992 - (21%)

  Fly    47 SRRKRILTPPSGPISLLLLTVLTLLILDTRSCQGLRLTNGGGSLSKGAAANKEQLNIGLIAPHTN 111
            |.|:..|...:| :|.:||.::..:.|..:  |.||:   ||...   ....|.:::..:|
Zfish    33 SSRRCALLKRTG-VSFILLCLMAEVGLSAQ--QVLRI---GGIFE---TLENEPISVEELA---- 84

  Fly   112 FGKREYLRSINNAVTGLTKTRGAKLTFLKDYSFEQKNIHFDMMSLTPSPTAILSTLCKEFLRVNV 176
                     ...|||.:.:.|.........|..::.|: ||  |...|..|     |.: |.:.|
Zfish    85 ---------FKFAVTNINRNRTLMPNTTLTYDIQRINL-FD--SFEASRRA-----CDQ-LALGV 131

  Fly   177 SAILYMMNNEQFGHSTASAQYFLQ-LAGYLGIPVIS--W---NADNSGLERRASQSTLQLQLAPS 235
            :|:        ||.|.:|:...:| :...|.:|.|.  |   :.||        :.:..:.|.|.
Zfish   132 AAV--------FGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDN--------KDSFYINLYPD 180

  Fly   236 IEHQSAAMLSILERYKWHQFSVVTSQIAGHDDFVQAVRERVAEMQEHFKFTILNSIVV------T 294
            ....|.|:|.|::.|||...:||      ::|....:|     :||..|.....||.:      |
Zfish   181 YASISRAVLDIVQFYKWKAVTVV------YEDATGLIR-----LQELIKAPSRYSIKIKIRQLPT 234

  Fly   295 RTSD----LMELVNSEARVMLLYATQTEAITILRAAEEMKLTGENYVWVVS-------------- 341
            .:.|    |.|:...:...::...:...|..:|:....|.:..|.|.:..:
Zfish   235 GSKDARPLLKEMKKGKEFCVIFDCSYQTAADVLKQLLSMGMMTEYYHFFFTTLDLYSLDLEPFRY 299

  Fly   342 ------------------QSVIEKKDAHS-QFPV--------GMLGVHFDTSSAALMNEISNAIK 379
                              .||:||..... |.|.        ||:     |:.||||
Zfish   300 SGVNMTGFRLLNIDNPQVASVVEKWSMERLQAPPKPETGLQDGMM-----TTEAALM-------- 351

  Fly   380 IYSYGVEAYLTDPANRDRRLTTQSLSCEDEGRGR-WDNGEIFFKYLRNVSIEGDLNKPNIEFTAD 443
               |.....:...:.|..::|..||.|.   |.: |..|..|....:.....|...:..|..| |
Zfish   352 ---YDAVYMVAAASQRASQITVSSLQCH---RHKPWRFGSRFISMFKEAQWNGLTGQIIINKT-D 409

  Fly   444 GDLRSAELKIMNLRPSANNK-------NLVWEEIGVWKSWETQKLDIRDIAWPGNSHAPPQGVPE 501
            |..:..:|.|::|:.....|       |.||::||||.|  ...|::.|.....|::........
Zfish   410 GLRKDFDLDIISLKEDGLEKPLESGRFNKVWKKIGVWNS--NTGLNLTDSNKDKNTNVTDSMANR 472

  Fly   502 KFHLKITFLEEAPYINLSPAD-PVSGKCLMDRGVLCRVAADHEMAADIDVGQAHRNESFYQCCSG 565
            .  |.:|.:.|.||:....:| |:.|                             |:.|    .|
Zfish   473 T--LIVTTILENPYVMYKKSDKPLYG-----------------------------NDRF----EG 502

  Fly   566 FCIDLLEKFAEELGFTYELVRVEDGKWGTL-ENGKWNGLIADLVNRKTDMVLTSLMINTEREAVV 629
            :|:|||::.:..|||:||:..|.|||:|.. :.|:|||::.:|::...|:.:..|.|...||.|:
Zfish   503 YCLDLLKELSNILGFSYEVKLVTDGKYGAQNDKGEWNGMVRELIDHVADLAVAPLTITYVREKVI 567

  Fly   630 DFSEPFMETGIAIVVAKRTGIISP--TAFLEPFDTASWM--LVGIVAIQAATFMIFLF---EWLS 687
            |||:|||..||:|:..|..| .:|  .:||.|.....||  |:..:.:....|:|..|   ||.:
Zfish   568 DFSKPFMTLGISILYHKPNG-TNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYN 631

  Fly   688 PSGYDMKLYLQNTNVTPYRFSLFRTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAI 752
            |...:     .:::|....|:|..:.|.....|.|....: .|:..::|.:..:|..|.::.::.
Zfish   632 PHPCN-----PDSDVVENNFTLINSVWFGVGALMQQGSEL-MPKALSTRIVGGIWWFFTLIIISS 690

  Fly   753 YTANLAAFMITREEFHEFSGLNDSRLVHPFSHKPSFKFGTIPYSHTDSTIHK----YFNVMHNYM 813
            ||||||||:............:|      .:.:...::|.:....|.:...|    .:..|..:|
Zfish   691 YTANLAAFLTVERMDSPIDSADD------LAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFM 749

  Fly   814 RQYNKTSVA----DGVAAVLNGNLDSFIYDGTVLDYLVAQDEDCRLMTVGSWYAMTGYGLAFSRN 874
            .....|::.    :|:..||..:. :.:.:.|.::|:  ...:|.|..:|......|||:.....
Zfish   750 SSRKNTALVKNNREGIQRVLTTDY-ALLMESTSIEYI--SQRNCNLTQIGGLIDSKGYGVGTPIG 811

  Fly   875 SKYVQMFNKRLLEFRANGDLERLRRYWMTGTCRPGKQEHKSSDPLALEQFLSAFLLLMAGILLAA 939
            |.|.......:|:.:..|.|..::..|..|...| :::.|.:..|.:|.....|::|.||::|:.
Zfish   812 SPYRDKVTIAILQLQEEGKLHMMKEKWWRGNGCP-EEDSKEASALGVENIGGIFIVLAAGLVLSV 875

  Fly   940 LLLLLEHVYFKYIRKRL 956
            .:.:.|.:|..  ||.|
Zfish   876 FVAIGEFIYKS--RKNL 890

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..485	CDD:380601	96/450 (21%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	103/422 (24%)
grik1b	XP_690040.5	PBP1_iGluR_Kainate	65..456	CDD:380605	99/467 (21%)
		Periplasmic_Binding_Protein_Type_2	471..840	CDD:473866	102/419 (24%)