DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar2 and grin2bb

DIOPT Version :9

Sequence 1:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster
Sequence 2:	NP_001121809.1	Gene:	grin2bb / 559976	ZFINID:	ZDB-GENE-061207-27	Length:	1770	Species:	Danio rerio

Alignment Length:	1077	Identity:	320/1077 - (29%)
Similarity:	512/1077 - (47%)	Gaps:	122/1077 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 ISLLLLTVLTLLILDTRSCQGLRLTNGGGSLSKGAAANKEQLNIGLIAPH------TNFG---KR 115
            |||||   |:|....|  |:..|   |||..:.....|.:.:   :..||      :..|   ..
Zfish    50 ISLLL---LSLFFFPT--CESRR---GGGIGTPTGGMNSQSI---ISPPHYPPPGVSPVGPPMSP 103

  Fly   116 EYLRSINNAVTGLTKTRGAKLTFLKDYSFEQKNIHFDMMSLTP----------SPTAILSTLCKE 170
            ::.:.::.||..:..:....|:    ...|:::  |..:.|.|          .|.:|::.:|..
Zfish   104 KFAQGLSIAVILVGNSSEVSLS----EGLEKED--FLHVPLPPKVELVTMNETDPKSIINRICAL 162

  Fly   171 FLRVNVSAILYMMNNEQFGHSTASAQYFLQLAGYLGIPVISWNADNSGLERRASQSTLQLQLAPS 235
            ..|..:..:::..:.:|    .|.||....::....||::.....:|.:.......::..|..||
Zfish   163 MSRNWLQGVVFGDDTDQ----EAIAQILDFISAQTHIPILGIRGGSSMIMAAKDDHSMFFQFGPS 223

  Fly   236 IEHQSAAMLSILERYKWHQFSVVTSQIAGHDDFVQAVRERVA------EMQEHFKFTILNSIVVT 294
            ||.|::.||:|:|.|.|:.||:||:...||.|||..:|..|.      |::|   ..:|:..|..
Zfish   224 IEQQASVMLNIMEEYDWYIFSIVTTYYPGHQDFVNRIRSTVDNSFVGWELEE---VLLLDMSVDD 285

  Fly   295 RTSDLM-ELVNSEARVMLLYATQTEAITILRAAEEMKLTGENYVWVVSQSVIEKKD-AHSQFPVG 357
            ..|.:. ::...::.|:|||.|:.||.||...|..:.|||..|.|:|...|....| ..:.||.|
Zfish   286 GDSKIQNQMKKLQSPVILLYCTKEEATTIFEVAHSVGLTGYGYTWIVPSLVAGDTDNVPNVFPTG 350

  Fly   358 MLGVHFDTSSAALMNEISNAIKIYSYGVEAYLTDPANRDRRLTTQSLSCE---DEGRGRWDNGEI 419
            ::.|.:|.....|...:.:|:.|.:......:.|....    |.....|.   |:...:..|...
Zfish   351 LISVSYDEWDYGLEARVRDAVAIIAMATSTMMLDRGPH----TLLKSGCHGAPDKKGSKSGNPNE 411

  Fly   420 FFKYLRNVSIEGDLNKPNIEFTADGDLRSAELKIMNLRPSANNKNLVWEEIGVWKSWETQKLDIR 484
            ..:||.||:.||    .|:.|:.||.....:|.|:.|     ||...:|.:|   .||...|.::
Zfish   412 VLRYLMNVTFEG----RNLSFSEDGFQMHPKLVIILL-----NKERQYERVG---KWENGSLAMK 464

  Fly   485 DIAWPGNSHAPPQGVPEKFHLKITFLEEAPYINLSPADPVSGKCLMDRGVLCRVAADHEMAADID 549
            ...||...........|..||.|..|||||::.:...||:||.| |...|.||        ..:.
Zfish   465 YHVWPRFELYSDAEEREDDHLSIVTLEEAPFVIVEDVDPLSGTC-MRNTVPCR--------KQLK 520

  Fly   550 VGQAHRNESFY--QCCSGFCIDLLEKFAEELGFTYELVRVEDGKWGTLENGKWNGLIADLVNRKT 612
            :.....:...|  :||.|||||:|:|.|:.:.|||:|..|.:||.|...||.|||::.::|.:..
Zfish   521 LQNLTGDSGIYIKRCCKGFCIDILKKIAKSVKFTYDLYLVTNGKHGKKINGTWNGMVGEVVLKNA 585

  Fly   613 DMVLTSLMINTEREAVVDFSEPFMETGIAIVVAKRTGIISPTAFLEPFDTASWMLVGIVAIQAAT 677
            .|.:.||.||.||..|:|||.||:||||:::|::..|.:||:||||||....|:::.::.:..:.
Zfish   586 HMAVGSLTINEERSEVIDFSVPFIETGISVMVSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSA 650

  Fly   678 FMIFLFEWLSPSGYDMKLYLQNTNVTPYRFSLFRTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVW 742
            ..:|:||:.||.||:..|........| .|::.:..||:|.::|..:|.|.:|:|.||:.|.:||
Zfish   651 VAVFVFEYFSPVGYNRCLADGREPGGP-SFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVW 714

  Fly   743 ALFAVVFLAIYTANLAAFMITREEFHEFSGLNDSRLVHPFSHKPSFKFGTIPYSHTDSTIHKYFN 807
            |.|||:|||.||||||||||..|...:.:||:|.:..||....|.|:|||:|...|:..|...:.
Zfish   715 AFFAVIFLASYTANLAAFMIQEEYVDQVTGLSDKKFQHPNDFSPPFRFGTVPNGSTERNIRNNYK 779

  Fly   808 VMHNYMRQYNKTSVADGVAAVLNGNLDSFIYDGTVLDYLVAQDEDCRLMTVGSWY--AMTGYGLA 870
            .||:||..:::.:|.:.:.::.:|.||:||||..||:|:..:||.|:|:|:||.|  |.||||:|
Zfish   780 EMHSYMTSFHQKNVNEALHSLKSGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGYIFATTGYGIA 844

  Fly   871 FSRNSKYVQMFNKRLLEFRANGDLERLRRYWMTGTCRPGKQEHKSSDPLALEQFLSAFLLLMAGI 935
            ..::|.:.:..:..:|:...:|::|.|...|:||.|...|.|..||. |.::.....|.:|.|.:
Zfish   845 IQKDSGWKRAVDLAILQLFGDGEMEELEALWLTGICHNEKNEVMSSQ-LDVDNMAGVFYMLGAAM 908

  Fly   936 LLAALLLLLEHVYFKYIRKRLAKKDGGHCCALISLSMGKSLTFRGAVFEATEILKKHRCNDPICD 1000
            .|:.:..:.||:::..:|........|......|:|.|......|...|.    .|...|.|...
Zfish   909 ALSLITFIAEHLFYWQLRFCFMGVCSGKPGMTFSISRGIYSCIHGVQIEE----NKSALNSPSAT 969

  Fly  1001 THLWKVKHELDMSRLRVRQLEKVMDKHGIK-APQLRLASSS------DLLNHH-----HLKERPP 1053
            ..:.......::.|| :|..:.:....|:. :|...|..|.      |:..|.     |...:||
Zfish   970 MKMNMNNTHSNILRL-LRTAKNMTSVPGVNGSPHSALDYSHRESAVYDISEHRRSLAGHSDCKPP 1033

  Fly  1054 ------------------LLGNLSLAASAQDLYRWSY 1072
                              ..|||.|..|  :||:..|
Zfish  1034 PYLPEDNMFSDYVSEVERTFGNLHLKDS--NLYQDHY 1068

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	101/420 (24%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	162/409 (40%)
		Lig_chan	665..928	CDD:278489	98/264 (37%)
grin2bb	NP_001121809.1	PBP1_iGluR_NMDA_NR2	107..470	CDD:107373	98/391 (25%)
		ANF_receptor	138..442	CDD:279440	83/318 (26%)
		PBP2_iGluR_NMDA_Nr2	482..882	CDD:270436	162/409 (40%)
		Lig_chan	636..908	CDD:278489	101/273 (37%)
		NMDAR2_C	919..1770	CDD:287527	31/157 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591425
Domainoid	1	1.000	218	1.000	Domainoid score	I2585
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	438	1.000	Inparanoid score	I1644
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D279143at33208
OrthoFinder	1	1.000	-	-		FOG0000775
OrthoInspector	1	1.000	-	-		otm24466
orthoMCL	1	0.900	-	-		OOG6_102799
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3072
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.790