DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nmdar2 and grik4

DIOPT Version :9

Sequence 1:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster
Sequence 2:	XP_021322087.1	Gene:	grik4 / 556582	ZFINID:	ZDB-GENE-070821-5	Length:	965	Species:	Danio rerio

Alignment Length:	969	Identity:	233/969 - (24%)
Similarity:	398/969 - (41%)	Gaps:	236/969 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 SGPISLLLLTVLTLLILDTRSCQGLRLTNGGGSLSKGAAANKEQLNIGLIAPHTNFGKREYLRSI 121
            |||:|..:..:|.    |...|            |:|     |:|.|.|.....|       ||.
Zfish    20 SGPLSFRIAAILD----DPMEC------------SRG-----ERLAITLAKDSIN-------RSS 56

  Fly   122 NNAVTGLTKTRGAKLTFLKDYSFEQKNIHFDMM----------SLTPSPTAILSTLCKE----FL 172
            |.:.||  |........|:|..:|.......:|          |.:|:..:|:|.:|.|    ::
Zfish    57 NRSTTG--KLEVDIFELLRDSEYETGETMCQIMSKGVVAVLGPSASPASNSIISNICGEKEVPYV 119

  Fly   173 RVNVSAILYMMNNEQFGHST------ASAQYFLQLAGYLGIPVISWNADNSGLERRASQSTLQL- 230
            :|....||.:    ||...|      .:....:.:||.|..    :|:..|.|....:...|.|
Zfish   120 KVAPEDILKV----QFPRFTTLDLRPTNTDISMAVAGLLTF----FNSSTSCLICAQADCLLNLE 176

  Fly   231 ----QLAPSIEHQSAAMLSILERYKWHQFSVVTSQIAGHDDFVQAVRERVAEMQEHFKFTI---- 287
                |...|.|..|..||                      |..|.....:.|:::....||
Zfish   177 VLLRQFLISKETLSVRML----------------------DDSQDPTPLLKEIRDDKTATIIVDA 219

  Fly   288 ---LNSIVVTRTSDLMELVNSEARVMLLYATQTEAITILR----AAEEMKLTG-----------E 334
               ::.:::.|.|:|..|     .|...|...:...::||    |.:.:.:.|           :
Zfish   220 NATMSHVILERASELGML-----SVYYTYILTSLEFSLLRLDDLADQRVNIVGFSVFNRTHPFFQ 279

  Fly   335 NYVWVVSQSVIEKKDAHSQFPVGMLGVHFDTSSAALMNEISNAIKIYSYGVEAYLTDPANRDRRL 399
            ::|..:::|..|..| |:.|....|      |||.|.:.:...:.         .....||.:.:
Zfish   280 DFVLSLNRSWQENCD-HAPFAGTPL------SSALLFDAVHTVVA---------AVQELNRSQNV 328

  Fly   400 TTQSLSCEDEGRGRWDNGEIFFKYLRNVSIEGDLNKPNIEFTADGDLRSAELKIMNLRPSANNKN 464
            ....|||:..  ..|::|.....|||.|.:||...  :|||.:.|...:..|:||.     |:::
Zfish   329 GATQLSCKSS--KIWEHGTSLMNYLRMVELEGLTG--HIEFNSKGQRSNYALRIMQ-----NSRD 384

  Fly   465 LVWEEIGVWKSWETQKLDIRDIAWPGNSHAPPQGVPEKFH---LKITFLEEAPYINLSPADPVSG 526
            .: .:||.|.|.:...::.:         .|...|.:...   |.||.:.|.||:.|
Zfish   385 GL-RQIGQWHSEQGLSMERK---------LPSLNVTDTLFNTTLTITTILENPYVML-------- 431

  Fly   527 KCLMDRGVLCRVAADHEMAADIDVGQAHRNESFYQCCSGFCIDLLEKFAEELGFTYELVRVEDGK 591
                        .|:|:        :...|:.:    .|||:|:|::.|:.|.|.|.:..|.||.
Zfish   432 ------------RANHQ--------ELEGNDRY----EGFCVDMLKELADILKFKYRIRLVGDGV 472

  Fly   592 WGTL-ENGKWNGLIADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGIAIV----VAKRTGII 651
            :|.. .||.|.|::.:|::||.|:.:.:|.|..|||.|:|||:|||..||:|:    :.:|.|..
Zfish   473 YGVPGANGTWTGMVGELISRKADLAVAALTITAEREKVIDFSKPFMTLGISIMYRVHIGRRPGYF 537

  Fly   652 SPTAFLEPFDTASW--MLVGIVAIQAATFMIFL---FEWLSP----SGYDMKLYLQNTNVTPYRF 707
            |   ||:||....|  ||:..:|:....|::..   :||.:|    .|....|..|        :
Zfish   538 S---FLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYNPHPCLKGRCSLLINQ--------Y 591

  Fly   708 SLFRTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAAFMITREEFHEFSG 772
            ||..::|.......|....: :||..::|.::.||..|.::.::.||||||||:..:........
Zfish   592 SLGNSFWFPVGGFMQQGSTI-APRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPIES 655

  Fly   773 LNDSRLVHPFSHKPSFKFGTIPYSHTDSTI-------HKYFNVMHNYMRQYNK------TSVADG 824
            ::|      .:.:.:.::||:   |..||:       ::.:..|.|:|  |:|      .|..:|
Zfish   656 VDD------LADQTAIEYGTM---HGGSTMTFFQNSRYQTYQRMWNFM--YSKQPSVFVKSTEEG 709

  Fly   825 VAAVLNGNLDSFIYDGTVLDYLVAQDEDCRLMTVGSWYAMTGYGLAFSRNSKYVQMFNKRLLEFR 889
            :|.|||.|. :::.:.|:.:|.  :..:|.|..:|......|||:.....|.|...|:..:|..:
Zfish   710 IARVLNSNY-AYLLESTMNEYY--RQRNCNLTQIGGLLDTKGYGIGMPLGSVYRDEFDLAILRLQ 771

  Fly   890 ANGDLERLRRYWMTGTCRPGKQEHKSSDPLALEQFLSAFLLLMAGILLAALLLLLEHVY 948
            ....||.|:|.|..|...|.:::|::.. |.:|.....|::|:.|:|:|..:.:||.|:
Zfish   772 EENRLEILKRKWWDGGKCPKEEDHRAKG-LGMENIGGIFVVLVCGLLVAIFMAVLEFVW 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	92/437 (21%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	118/435 (27%)
		Lig_chan	665..928	CDD:278489	69/284 (24%)
grik4	XP_021322087.1	Periplasmic_Binding_Protein_Type_1	26..400	CDD:324556	97/464 (21%)
grik4	XP_021322087.1	PBP2_iGluR_kainate_KA1	425..785	CDD:270442	114/417 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590979
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.740