DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nmdar2 and Grik2

DIOPT Version :9

Sequence 1:NP_001014714.1 Gene:Nmdar2 / 31107 FlyBaseID:FBgn0053513 Length:1083 Species:Drosophila melanogaster
Sequence 2:NP_062182.1 Gene:Grik2 / 54257 RGDID:2733 Length:908 Species:Rattus norvegicus


Alignment Length:965 Identity:224/965 - (23%)
Similarity:387/965 - (40%) Gaps:213/965 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   118 LRSINNAVTGLTKTRGAKLTF------LKDYSFEQKNIHFDMMSLTPSPTAILSTLCKEFLRVNV 176
            :.:||...|.|..|   .||:      |.| |||......|.:||                  .|
  Rat    61 VNTINRNRTLLPNT---TLTYDTQKINLYD-SFEASKKACDQLSL------------------GV 103

  Fly   177 SAILYMMNNEQFGHS-TASAQYFLQLAGYLGIPVIS--WN---ADNSGLERRASQSTLQLQLAPS 235
            :||        ||.| ::||.....:...||:|.|.  |.   :||        :.:..:.|.|.
  Rat   104 AAI--------FGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDN--------KDSFYVSLYPD 152

  Fly   236 IEHQSAAMLSILERYKWHQFSVVTSQIAGHDDFVQAVR-ERVAEMQEHFKFTILNSIVVTRTSD- 298
            ....|.|:|.:::.:||...:||      :||....:| :.:.:....:...:....:...|.| 
  Rat   153 FSSLSRAILDLVQFFKWKTVTVV------YDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKDA 211

  Fly   299 ---LMELVNSEARVMLLYATQTEAITILRAAEEMKLTGENYVWVVS------------------- 341
               |.|:...:...::...:...|..||:.|..|.:..|.|.::.:                   
  Rat   212 KPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNM 276

  Fly   342 -------------QSVIEKKDAHS-QFP----VGMLGVHFDTSSAALMNEISNAIKIYSYGVEAY 388
                         .|:|||..... |.|    .|:|. .|.|:.||||.:   |:.:.|..|:.:
  Rat   277 TGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLD-GFMTTDAALMYD---AVHVVSVAVQQF 337

  Fly   389 LTDPANRDRRLTTQSLSCEDEGRGR-WDNGEIFFKYLRNVSIEGDLNKPNIEFTADGDLRS-AEL 451
                    .::|..||.|   .|.: |..|..|...::....||...:  |.|.....||: .:|
  Rat   338 --------PQMTVSSLQC---NRHKPWRFGTRFMSLIKEAHWEGLTGR--ITFNKTNGLRTDFDL 389

  Fly   452 KIMNLRPSANNKNLVWEEIGVWKSWETQKLDIRDIAWPGNSHAPPQGVPEKF---HLKITFLEEA 513
            .:::|:.....|...|:........|:||             ..|..:.:..   .|.:|.:.|.
  Rat   390 DVISLKEEGLEKIGTWDPASGLNMT
ESQK-------------GKPANITDSLSNRSLIVTTILEE 441

  Fly   514 PYINLSPAD-PVSGKCLMDRGVLCRVAADHEMAADIDVGQAHRNESFYQCCSGFCIDLLEKFAEE 577
            ||:....:| |:.|                             |:.|    .|:|||||.:.:..
  Rat   442 PYVLFKKSDKPLYG-----------------------------NDRF----EGYCIDLLRELSTI 473

  Fly   578 LGFTYELVRVEDGKWGTLE--NGKWNGLIADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGI 640
            ||||||:..|||||:|..:  ||:|||::.:|::.|.|:.:..|.|...||.|:|||:|||..||
  Rat   474 LGFTYEIRLVEDGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGI 538

  Fly   641 AIVVAKRTGIISP--TAFLEPFDTASWM--LVGIVAIQAATFMIFLF---EWLSPSGYDMKLYLQ 698
            :|:..|..| .:|  .:||.|.....||  |:..:.:....|:|..|   ||.:|...:     .
  Rat   539 SILYRKPNG-TNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFSPYEWYNPHPCN-----P 597

  Fly   699 NTNVTPYRFSLFRTYWL-VWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAAFMI 762
            :::|....|:|..::|. |.|::.|.:..:  |:..::|.:..:|..|.::.::.||||||||:.
  Rat   598 DSDVVENNFTLLNSFWFGVGALMRQGSELM--PKALSTRIVGGIWWFFTLIIISSYTANLAAFLT 660

  Fly   763 TREEFHEFSGLNDSRLVHPFSHKPSFKFGTIPYSHT--------DSTIHKYFNVMHNYMRQYNKT 819
            ...........:|      .:.:...::|.:....|        .||..|.:..|.:..:.....
  Rat   661 VERMESPIDSADD------LAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVK 719

  Fly   820 SVADGVAAVLNGNLDSFIYDGTVLDYLVAQDEDCRLMTVGSWYAMTGYGLAFSRNSKYVQMFNKR 884
            |..:|:..||..:. :|:.:.|.::::.  ..:|.|..:|......|||:.....|.|.......
  Rat   720 SNEEGIQRVLTSDY-AFLMESTTIEFVT--QRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIA 781

  Fly   885 LLEFRANGDLERLRRYWMTGTCRPGKQEHKSSDPLALEQFLSAFLLLMAGILLAALLLLLEHVYF 949
            :|:.:..|.|..::..|..|...| ::|.|.:..|.::.....|::|.||::|:..:.:.|.:|.
  Rat   782 ILQLQEEGKLHMMKEKWWRGNGCP-EEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYK 845

  Fly   950 KYIRKRLAKKDGGHCCALI-----SLSMGKSLTFR---GAVFEATEILKKHRCND 996
            .....:|.|:  ..|.|::     ||...:.|..:   ..:.:..|::..|..||
  Rat   846 SKKNAQLEKR--SFCSAMVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFND 898

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Nmdar2NP_001014714.1 PBP1_iGluR_NMDA_NR2 99..490 CDD:107373 91/427 (21%)
PBP2_iGluR_NMDA_Nr2 502..908 CDD:270436 110/427 (26%)
Lig_chan 665..928 CDD:278489 58/276 (21%)
Grik2NP_062182.1 Periplasmic_Binding_Protein_Type_1 34..414 CDD:299141 88/413 (21%)
ANF_receptor 52..395 CDD:279440 85/394 (22%)
Periplasmic_Binding_Protein_Type_2 430..800 CDD:304360 109/419 (26%)
Glutamate binding. /evidence=ECO:0000269|PubMed:15721240, ECO:0000269|PubMed:17115050, ECO:0007744|PDB:1S50, ECO:0007744|PDB:1S7Y, ECO:0007744|PDB:2I0B, ECO:0007744|PDB:2I0C 516..518 0/1 (0%)
Lig_chan 562..831 CDD:278489 61/285 (21%)