DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nmdar2 and Gria3

DIOPT Version :9

Sequence 1:NP_001014714.1 Gene:Nmdar2 / 31107 FlyBaseID:FBgn0053513 Length:1083 Species:Drosophila melanogaster
Sequence 2:NP_001268858.2 Gene:Gria3 / 53623 MGIID:95810 Length:888 Species:Mus musculus


Alignment Length:896 Identity:206/896 - (22%)
Similarity:350/896 - (39%) Gaps:214/896 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   148 NIHFDMMSLTPSPTAILSTLCKEFLRVNVSAILYMMNNEQFG-HSTASAQYFLQLAGYLGIPVI- 210
            |.|.|.:..:.| .::.:..|.:|.| .|.||        || :...|........|.|....: 
Mouse    66 NYHVDHLDSSNS-FSVTNAFCSQFSR-GVYAI--------FGFYDQMSMNTLTSFCGALHTSFVT 120

  Fly   211 -SWNADNSGLERRASQSTLQLQLAPSIEHQSAAMLSILERYKWHQ----------FSV------- 257
             |:..|        :.....:|:.|:::   .|:||:|..|||.:          ||:       
Mouse   121 PSFPTD--------ADVQFVIQMRPALK---GAILSLLGYYKWEKFVYLYDTERGFSILQAIMEA 174

  Fly   258 -------VTSQIAGHDDFVQAVRERVAEMQEHFKFTILNSIVVTRTSDLME---LVNSEAR---V 309
                   ||::..|:...:|..|..:.||....:...|....|.|.:.::|   ::...:|   .
Mouse   175 AVQNNWQVTARSVGNIKDIQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHY 239

  Fly   310 MLLYATQTEAITILRAAEEMKLTG---------------ENYVWVVSQSVIEKKDAHSQFPVGML 359
            ||.....|:.:..........:||               :.:|.:..:...|.|:|..::     
Mouse   240 MLANLGFTDIVLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKNAPLKY----- 299

  Fly   360 GVHFDTSSAALMNEISNAIKIYSYGVEAYLTDPANRDRRLTTQSLSCEDEGRG---------RWD 415
                   ::||.::   ||.:.:   ||:        |.|..|.:.....|..         .|.
Mouse   300 -------TSALTHD---AILVIA---EAF--------RYLRRQRVDVSRRGSAGDCLANPAVPWS 343

  Fly   416 NGEIFFKYLRNVSIEGDLNKPNIEFTADGDLRSAELKIMNLRPSANNKNLVWEEIGVWKSWETQK 480
            .|....:.|:.|.::|...  ||:|...|...:..:.:..::.|.:.|      .|.|..:|   
Mouse   344 QGIDIERALKMVQVQGMTG--NIQFDTYGRRTNYTIDVYEMKVSGSRK------AGYWNEYE--- 397

  Fly   481 LDIRDIAWPGNSHAPPQGVPEKFHLKITFLEEAPYINLSPADPVSGKCLMDRGVLCRVAADHEMA 545
               |.:.:.....:......|...:.:|.:.|:||:                    ....:||  
Mouse   398 ---RFVPFS
DQQISNDSSSSENRTIVVTTILESPYV--------------------MYKKNHE-- 437

  Fly   546 ADIDVGQAHRNESFYQCCSGFCIDLLEKFAEELGFTYELVRVEDGKWGTL--ENGKWNGLIADLV 608
                  |...||.:    .|:|:||..:.|:.:...|:|..|.|||:|..  |...|||::.:||
Mouse   438 ------QLEGNERY----EGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELV 492

  Fly   609 NRKTDMVLTSLMINTEREAVVDFSEPFMETGIAIVVAK----RTGIISPTAFLEPFDTASWMLVG 669
            ..:.|:.:..|.|...||.|:|||:|||..||:|::.|    :.|:.|   ||:|.....||.: 
Mouse   493 YGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFS---FLDPLAYEIWMCI- 553

  Fly   670 IVAIQAATFMIFLFEWLSPSGYDMKLYLQNTNV----------TPYRFSLFRTYWLVWAVLFQAA 724
            :.|....:.::||....||  |:.  :|::.|.          .|..|.:|.:.|.......|..
Mouse   554 VFAYIGVSVVLFLVSRFSP--YEW--HLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQG 614

  Fly   725 VHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAAFMITREEFHEFSGLNDSRLVHP------FS 783
            ..: |||..:.|.:..||..|.::.::.||||||||            |...|:|.|      .:
Mouse   615 CDI-SPRSLSGRIVGGVWWFFTLIIISSYTANLAAF------------LTVERMVSPIESAEDLA 666

  Fly   784 HKPSFKFGTIPYSHTDSTIHK----YFNVMHNYMRQ-----YNKTSVADGVAAV--LNGNLDSFI 837
            .:....:||:....|.....:    .:..|.:||:.     :.||: |||||.|  ..|.. :|:
Mouse   667 KQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTT-ADGVARVRKSKGKF-AFL 729

  Fly   838 YDGTVLDYLVAQDEDCRLMTVGSWYAMTGYGLAFSRNSKYVQMFNKRLLEFRANGDLERLRRYWM 902
            .:.|:.:| :.|.:.|..|.||......|||:|..:.|......|..:|:....|.|::|:..|.
Mouse   730 LESTMNEY-IEQRKPCDTMKVGGNLDSKGYGVATPKGSALRTPVNLAVLKLSEQGILDKLKNKWW 793

  Fly   903 --TGTCRPGKQEHKSSD---PLALEQFLSAFLLLMAGILLAALLLLLEHVY 948
              .|.|  |.::..|.|   .|:|......|.:|:.|:.||.::.|:|..|
Mouse   794 YDKGEC--GAKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCY 842

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Nmdar2NP_001014714.1 PBP1_iGluR_NMDA_NR2 99..490 CDD:107373 74/398 (19%)
PBP2_iGluR_NMDA_Nr2 502..908 CDD:270436 118/440 (27%)
Lig_chan 665..928 CDD:278489 75/294 (26%)
Gria3NP_001268858.2 PBP1_iGluR_AMPA_GluR3 29..403 CDD:380610 74/397 (19%)
PBP2_iGluR_AMPA 416..799 CDD:270433 117/438 (27%)
Glutamate binding 502..504 0/1 (0%)