Protein Alignment Nmdar2 and Gria3

DIOPT Version :10

• Sequence 1: NP_001014714.1
• Gene: Nmdar2 / 31107
• FlyBaseID: FBgn0053513
• Length: 1083
• Species: Drosophila melanogaster
• Sequence 2: NP_058582.4
• Gene: Gria3 / 53623
• MGIID: 95810
• Length: 888
• Species: Mus musculus
• Alignment Length: 896
• Identity: 206/896 - (22%)
• Similarity: 350/896 - (39%)
• Gaps: 214/896 - (23%)

  Fly   148 NIHFDMMSLTPSPTAILSTLCKEFLRVNVSAILYMMNNEQFG-HSTASAQYFLQLAGYLGIPVI- 210
            |.|.|.:..:.| .::.:..|.:|.| .|.||        || :...|........|.|....:
Mouse    66 NYHVDHLDSSNS-FSVTNAFCSQFSR-GVYAI--------FGFYDQMSMNTLTSFCGALHTSFVT 120

  Fly   211 -SWNADNSGLERRASQSTLQLQLAPSIEHQSAAMLSILERYKWHQ----------FSV------- 257
             |:..|        :.....:|:.|:::   .|:||:|..|||.:          ||:
Mouse   121 PSFPTD--------ADVQFVIQMRPALK---GAILSLLGYYKWEKFVYLYDTERGFSILQAIMEA 174

  Fly   258 -------VTSQIAGHDDFVQAVRERVAEMQEHFKFTILNSIVVTRTSDLME---LVNSEAR---V 309
                   ||::..|:...:|..|..:.||....:...|....|.|.:.::|   ::...:|   .
Mouse   175 AVQNNWQVTARSVGNIKDIQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHY 239

  Fly   310 MLLYATQTEAITILRAAEEMKLTG---------------ENYVWVVSQSVIEKKDAHSQFPVGML 359
            ||.....|:.:..........:||               :.:|.:..:...|.|:|..::
Mouse   240 MLANLGFTDIVLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKNAPLKY----- 299

  Fly   360 GVHFDTSSAALMNEISNAIKIYSYGVEAYLTDPANRDRRLTTQSLSCEDEGRG---------RWD 415
                   ::||.::   ||.:.:   ||:        |.|..|.:.....|..         .|.
Mouse   300 -------TSALTHD---AILVIA---EAF--------RYLRRQRVDVSRRGSAGDCLANPAVPWS 343

  Fly   416 NGEIFFKYLRNVSIEGDLNKPNIEFTADGDLRSAELKIMNLRPSANNKNLVWEEIGVWKSWETQK 480
            .|....:.|:.|.::|...  ||:|...|...:..:.:..::.|.:.|      .|.|..:|
Mouse   344 QGIDIERALKMVQVQGMTG--NIQFDTYGRRTNYTIDVYEMKVSGSRK------AGYWNEYE--- 397

  Fly   481 LDIRDIAWPGNSHAPPQGVPEKFHLKITFLEEAPYINLSPADPVSGKCLMDRGVLCRVAADHEMA 545
               |.:.:.....:......|...:.:|.:.|:||:                    ....:||
Mouse   398 ---RFVPFSDQQISNDSSSSENRTIVVTTILESPYV--------------------MYKKNHE-- 437

  Fly   546 ADIDVGQAHRNESFYQCCSGFCIDLLEKFAEELGFTYELVRVEDGKWGTL--ENGKWNGLIADLV 608
                  |...||.:    .|:|:||..:.|:.:...|:|..|.|||:|..  |...|||::.:||
Mouse   438 ------QLEGNERY----EGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELV 492

  Fly   609 NRKTDMVLTSLMINTEREAVVDFSEPFMETGIAIVVAK----RTGIISPTAFLEPFDTASWMLVG 669
            ..:.|:.:..|.|...||.|:|||:|||..||:|::.|    :.|:.|   ||:|.....||.:
Mouse   493 YGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFS---FLDPLAYEIWMCI- 553

  Fly   670 IVAIQAATFMIFLFEWLSPSGYDMKLYLQNTNV----------TPYRFSLFRTYWLVWAVLFQAA 724
            :.|....:.::||....||  |:.  :|::.|.          .|..|.:|.:.|.......|..
Mouse   554 VFAYIGVSVVLFLVSRFSP--YEW--HLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQG 614

  Fly   725 VHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAAFMITREEFHEFSGLNDSRLVHP------FS 783
            ..: |||..:.|.:..||..|.::.::.||||||||            |...|:|.|      .:
Mouse   615 CDI-SPRSLSGRIVGGVWWFFTLIIISSYTANLAAF------------LTVERMVSPIESAEDLA 666

  Fly   784 HKPSFKFGTIPYSHTDSTIHK----YFNVMHNYMRQ-----YNKTSVADGVAAV--LNGNLDSFI 837
            .:....:||:....|.....:    .:..|.:||:.     :.||: |||||.|  ..|.. :|:
Mouse   667 KQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTT-ADGVARVRKSKGKF-AFL 729

  Fly   838 YDGTVLDYLVAQDEDCRLMTVGSWYAMTGYGLAFSRNSKYVQMFNKRLLEFRANGDLERLRRYWM 902
            .:.|:.:| :.|.:.|..|.||......|||:|..:.|......|..:|:....|.|::|:..|.
Mouse   730 LESTMNEY-IEQRKPCDTMKVGGNLDSKGYGVATPKGSALRTPVNLAVLKLSEQGILDKLKNKWW 793

  Fly   903 --TGTCRPGKQEHKSSD---PLALEQFLSAFLLLMAGILLAALLLLLEHVY 948
              .|.|  |.::..|.|   .|:|......|.:|:.|:.||.::.|:|..|
Mouse   794 YDKGEC--GAKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCY 842

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..485	CDD:380601	73/393 (19%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	118/440 (27%)
Gria3	NP_058582.4	PBP1_iGluR_AMPA_GluR3	29..403	CDD:380610	74/397 (19%)
		PBP2_iGluR_AMPA	416..799	CDD:270433	117/438 (27%)