Protein Alignment Nmdar2 and Gria1

DIOPT Version :10

• Sequence 1: NP_001014714.1
• Gene: Nmdar2 / 31107
• FlyBaseID: FBgn0053513
• Length: 1083
• Species: Drosophila melanogaster
• Sequence 2: NP_113796.1
• Gene: Gria1 / 50592
• RGDID: 621531
• Length: 907
• Species: Rattus norvegicus
• Alignment Length: 922
• Identity: 205/922 - (22%)
• Similarity: 352/922 - (38%)
• Gaps: 204/922 - (22%)

  Fly   138 FLKDYSFEQKNIHFDMMSLTPSPTAI--------------LSTLCKEFLRVNVSAILYMMNNEQF 188
            |....|.|.....|.:..||..|..:              ....|.:|.: .|.||        |
  Rat    31 FPNQQSQEHAAFRFALSQLTEPPKLLPQIDIVNISDSFEMTYRFCSQFSK-GVYAI--------F 86

  Fly   189 G-HSTASAQYFLQLAGYLGIPVI--SWNADNSGLERRASQSTLQLQLAPSIEHQSAAMLSILERY 250
            | :...:........|.|.:..|  |:..|.|        :...|||.|.::.   |::||::.|
  Rat    87 GFYERRTVNMLTSFCGALHVCFITPSFPVDTS--------NQFVLQLRPELQE---ALISIIDHY 140

  Fly   251 KWHQFSVVTSQIAGHDDFVQAVRERVAEMQEHFKFTILNSIVVTRTSDLM---ELVNSEARVMLL 312
            ||..|..:.....|. ..:|.|.:..||  ::::.|.:|.:..|.....|   :|...:.|::::
  Rat   141 KWQTFVYIYDADRGL-SVLQRVLDTAAE--KNWQVTAVNILTTTEEGYRMLFQDLEKKKERLVVV 202

  Fly   313 YATQTEAITILRAAEEMKLTGENYVWVVSQ------SVIEKKDAHSQFPVGMLGVHFDTSSAALM 371
            .........||....:::..|..|.::::.      .:.:.|::.:......|..:.||..|.:|
  Rat   203 DCESERLNAILGQIVKLEKNGIGYHYILANLGFMDIDLNKFKESGANVTGFQLVNYTDTIPARIM 267

  Fly   372 NE-----------------------ISNAIKIYSYGVEAYLTDPANRDRRLTTQSLSCEDEGRG- 412
            .:                       ..:.:|:.:   ||:        :.|..|.:.....|..
  Rat   268 QQWRTSDSRDHTRVDWKRPKYTSALTYDGVKVMA---EAF--------QSLRRQRIDISRRGNAG 321

  Fly   413 --------RWDNGEIFFKYLRNVSIEGDLNKPNIEFTADGDLRSAELKIMNLRPSANNKNLVWEE 469
                    .|..|....:.|:.|..||...  |::|...|...:..|.::.::.....|
  Rat   322 DCLANPAVPWGQGIDIQRALQQVRFEGLTG--NVQFNEKGRRTNYTLHVIEMKHDGIRK------ 378

  Fly   470 IGVWKSWETQKLDIRDIAWPGNSHAPPQG----VPEKFHLKITFLEEAPYINLSPADPVSGKCLM 530
            ||.|.  |..|.      .|..:.|...|    |..:.::..|.||: ||:.|..
  Rat   379 IGYWN--EDDKF------VPAATDAQAGGDNSSVQNRTYIVTTILED-PYVMLKK---------- 424

  Fly   531 DRGVLCRVAADHEMAADIDVGQAHRNESFYQCCSGFCIDLLEKFAEELGFTYELVRVEDGKWGTL 595
                              :..|...|:.:    .|:|::|..:.|:.:|::|.|..|.|||:|..
  Rat   425 ------------------NANQFEGNDRY----EGYCVELAAEIAKHVGYSYRLEIVSDGKYGAR 467

  Fly   596 --ENGKWNGLIADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGIAIVVAK----RTGIISPT 654
              :...|||::.:||..:.|:.:..|.|...||.|:|||:|||..||:|::.|    :.|:.|
  Rat   468 DPDTKAWNGMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFS-- 530

  Fly   655 AFLEPFDTASWMLVGIVAIQAATFMIFL------FEWLS---PSGYDMKLYLQNTNVTPYRFSLF 710
             ||:|.....||.: :.|....:.::||      :||.|   ..|.|     |.|:.....|.:|
  Rat   531 -FLDPLAYEIWMCI-VFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRD-----QTTSDQSNEFGIF 588

  Fly   711 RTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAAFMITREEFHEFSGLND 775
            .:.|.......|....: |||..:.|.:..||..|.::.::.||||||||            |..
  Rat   589 NSLWFSLGAFMQQGCDI-SPRSLSGRIVGGVWWFFTLIIISSYTANLAAF------------LTV 640

  Fly   776 SRLVHP------FSHKPSFKFGTIPYSHTDSTIHK----YFNVMHNYMRQYNKT----SVADGVA 826
            .|:|.|      .:.:....:||:....|.....:    .|..|..||:....:    :..:|:.
  Rat   641 ERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMI 705

  Fly   827 AVLNG-NLDSFIYDGTVLDYLVAQDEDCRLMTVGSWYAMTGYGLAFSRNSKYVQMFNKRLLEFRA 890
            .|... ...:::.:.|:.:| :.|.:.|..|.||......|||:|..:.|......|..:|:...
  Rat   706 RVRKSKGKYAYLLESTMNEY-IEQRKPCDTMKVGGNLDSKGYGIATPKGSALRNPVNLAVLKLNE 769

  Fly   891 NGDLERLRRYWM--TGTCRPGKQEHK-SSDPLALEQFLSAFLLLMAGILLAALLLLLEHVYFKYI 952
            .|.|::|:..|.  .|.|..|..:.| .:..|:|......|.:|:.|:.||.|:.|:|   |.|.
  Rat   770 QGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIE---FCYK 831

  Fly   953 RKRLAKKDGGHC 964
            .:..:|:..|.|
  Rat   832 SRSESKRMKGFC 843

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..485	CDD:380601	74/404 (18%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	110/437 (25%)
Gria1	NP_113796.1	PBP1_iGluR_AMPA_GluR1	26..392	CDD:380613	75/410 (18%)
		PBP2_iGluR_AMPA_GluR1	406..787	CDD:270447	109/436 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	857..881
		PDZ-binding	904..907