DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nmdar2 and grin2da

DIOPT Version :9

Sequence 1:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster
Sequence 2:	XP_009292354.1	Gene:	grin2da / 449864	ZFINID:	ZDB-GENE-041008-124	Length:	1916	Species:	Danio rerio

Alignment Length:	925	Identity:	275/925 - (29%)
Similarity:	454/925 - (49%)	Gaps:	132/925 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 SPTAILSTLCKEFLRVNVSAILYMMNNEQFGHSTASAQYFLQLAGYLGIPVISWNADNSGLERRA 223
            ||.::|..||:......:..:::........:....|.....::...|:|||:... .:||.|..
Zfish   122 SPGSLLLQLCELLATTPLQGLVFEEEKPPPPNRAPLAPMLEFVSAQTGVPVIAVGG-GAGLGREP 185

  Fly   224 SQS-TLQLQLAPSIEHQSAAMLSILERYKWHQFSVVTSQIAGHDDFVQAVRERVA------EMQE 281
            .:| ::.||.:.|.:.|...:..:||.:.|..|||||::..|::||:..|...:.      |.:.
Zfish   186 QESGSVYLQFSCSTDLQLEVIFEVLEEFDWTAFSVVTTRHHGYEDFLAMVEGMIDGSFIGWERKS 250

  Fly   282 HFKFTILNSIVVTRTSDLMELVNSEARVMLLYATQTEAITILRAAEEMKLTGENYVWVVSQSVIE 346
            .....:.:.....||..|::  .:||:|.|||.:|.||..|.:||           |...|:.
Zfish   251 VVMLNLTDDPGGARTRRLLK--ENEAQVRLLYCSQEEAEQIFKAA-----------WASGQAT-- 300

  Fly   347 KKDAHSQFPV--GMLGVHFDTSSAALM------------NEISNAIKIYSYGVEAYLTDPANRDR 397
              .:|..|.|  |:.|:..:....||.            ..|:..:.:.::|..|...:...  .
Zfish   301 --PSHMWFAVGPGLSGLGLEGLPKALFAVRPQGWRDEPRRRIAKGVSVLTHGAMALRREYGG--A 361

  Fly   398 RLTTQSLSCEDEGR------GRWDNGEIFFKYLRNVSIEGDLNKPNIEFTADGDLRSAELKIMNL 456
            |.|:.:.:|..:|.      ||       .::..|:::.|    .:..|..||.|.:..|.:::.
Zfish   362 RGTSFAGNCMMDGNQTQRVPGR-------IRFFSNITLSG----RDYSFNNDGYLANPLLDVISY 415

  Fly   457 RPSANNKNLVWEEIGVWKSWETQKLDIRDIAWPGNSHAP-PQGVPEKFHLKITFLEEAPYINLSP 520
            .....     |||:| |  ||...|.:|...|  :.:.| .:.:.:..||::..|||.|::.:.|
Zfish   416 TAGRG-----WEEVG-W--WENGVLRLRYPPW--SRYGPFLKPLDDSQHLRVVTLEERPFVIVEP 470

  Fly   521 ADPVSGKCLMDRGVLCRVAADHEMAADIDVGQAHRNESFYQCCSGFCIDLLEKFAEELGFTYELV 585
            |||.:|.|:.| .|.||:..::.|..:       ..:|...||.|||||:|::.|:.:||||:|.
Zfish   471 ADPGTGSCIRD-SVPCRLPLNNSMVVE-------GIQSMKHCCKGFCIDVLKRLAKIVGFTYDLY 527

  Fly   586 RVEDGKWGTLENGKWNGLIADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGIAIVVAKRTGI 650
            .|.:|:.|...:|:|||::.::|:::.||.:.||.||.||..||:||.||:||||:::|::..|.
Zfish   528 LVTNGRHGKNIDGQWNGMVGEVVSKRADMAIGSLTINEERSEVVEFSVPFVETGISVMVSRSNGT 592

  Fly   651 ISPTAFLEPFDTASWMLVGIVAIQAATFMIFLFEWLSPSGYDMKLYLQNTNVTPYRFSLFRTYWL 715
            :||:|||||:..|.|:::.::.:......:|:||:.||.||:..|....| ....:|::.::.||
Zfish   593 VSPSAFLEPYSPAVWVMMFVMCLSVVAVTVFIFEFFSPVGYNRSLQSGKT-AGGSKFTIGKSIWL 656

  Fly   716 VWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAAFMITREEFHEFSGLNDSRLVH 780
            :||::|..:|.|::|||.||:.|..|||.|||:|||.||||||||||..|.....|||:|.:..|
Zfish   657 LWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYIDTVSGLSDKKFQH 721

  Fly   781 PFSHKPSFKFGTIPYSHTDSTIHKYFNVMHNYMRQYNKTSVADGVAAVLNGNLDSFIYDGTVLDY 845
            |....|..:|||:|...|:..|...:..||.||.:.|:..|.|.:..:..|.||:||||..||:|
Zfish   722 PTEQYPPLRFGTVPNGSTEENIRSNYPNMHQYMVRNNQRGVEDAIENLKTGKLDAFIYDAAVLNY 786

  Fly   846 LVAQDEDCRLMTVGSW--YAMTGYGLAFSRNSKYVQMFNKRLLEFRANGDLERLRRYWMTGTCRP 908
            :..:||.|::||:||.  :|.||||:|..:||::.:..:..||:...:.:::.|.|.|::|.|..
Zfish   787 MARKDEGCKVMTIGSGKVFATTGYGVALHKNSRWKRPLDLALLQLVGDDEIDMLERLWLSGICHN 851

  Fly   909 GKQEHKSSDPLALEQFLSAFLLLMAGILLAALLLLLEHVYFKYIRKRLAKKDGGHCCALISLSMG 973
            .|.|..|| .|.::.....|.:|:..:.|:.|:...||:.:..:|         ||       :|
Zfish   852 DKIEVMSS-KLDIDNMAGVFYMLLVAMGLSLLVFAWEHLVYWKLR---------HC-------LG 899

  Fly   974 KSLTFRGAVFEATEILKKHRCNDPICDTHLWKVKHELDMSRLRVRQLEKVMDKHGIKAPQLRLAS 1038
            ::   ||                             ||......|.:....:.....||.   .|
Zfish   900 RT---RG-----------------------------LDFLLAFSRGMYSCCNFEDETAPG---GS 929

  Fly  1039 SSDLLNHHHLKERPP 1053
            .|.|..:||:...||
Zfish   930 QSTLPQYHHVSTVPP 944

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	81/357 (23%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	164/407 (40%)
		Lig_chan	665..928	CDD:278489	101/264 (38%)
grin2da	XP_009292354.1	PBP1_iGluR_NMDA_NR2	42..441	CDD:107373	81/359 (23%)
		PBP2_iGluR_NMDA_Nr2	452..851	CDD:270436	164/407 (40%)
		HisJ	<507..>590	CDD:223904	39/82 (48%)
		Lig_chan	605..877	CDD:278489	104/273 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591779
Domainoid	1	1.000	218	1.000	Domainoid score	I2585
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D279143at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24466
orthoMCL	1	0.900	-	-		OOG6_102799
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.710