DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar2 and Ir93a

DIOPT Version :9

Sequence 1:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster
Sequence 2:	NP_650924.3	Gene:	Ir93a / 42471	FlyBaseID:	FBgn0259215	Length:	868	Species:	Drosophila melanogaster

Alignment Length:	970	Identity:	191/970 - (19%)
Similarity:	343/970 - (35%)	Gaps:	293/970 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 AKLTFLKDYSF---EQKNI--HFDMMSLTPSPTAILSTLCKEFLR---VNVSAILYMMNNEQFGH 190
            |.|..:.|:.:   ..:||  ||:         .|||.:.:|.||   :||
  Fly    39 ASLAVVVDHEYMTVHGENILAHFE---------KILSDVIRENLRNGGINV-------------- 80

  Fly   191 STASAQYFLQLAGYLGIPVISWNA----------------DNSGLERRASQSTLQLQLA------ 233
                 :||            ||||                :|:....:.:|.|..|.:|
  Fly    81 -----KYF------------SWNAVRLKKDFLAAITVTDCENTWNFYKNTQETSILLIAITDSDC 128

  Fly   234 PSIEHQSAAMLSILERYKWHQFSVVTSQIAGHDDFVQAVRERVAEMQEHFKF---------TIL- 288
            |.:....|.|:.|:|               ..|:|.|.:.:  |::|:...:         |||
  Fly   129 PRLPLNRALMVPIVE---------------NGDEFPQLILD--AKVQQILNWKTAVVFVDQTILE 176

  Fly   289 ------NSIV-------VTRTSDLMELVNSEARVMLLYATQTEAITILRAA--------EEMKLT 332
                  .|||       :|..|.::..:|...|      .|.:.:.:.:|.        |||:
  Fly   177 ENALLVKSIVHESITNHITPISLILYEINDSLR------GQQKRVALRQALSQFAPKKHEEMR-- 233

  Fly   333 GENYVWVVS---QSVIEKKDAHSQFPVG---------MLGVHFDTSSAAL-MNEISNAIKIYSYG 384
             :.:: |:|   :.:||..:..:.|.||         |:...||..:..: ::|.:|    .::.
  Fly   234 -QQFL-VISAFHEDIIEIAETLNMFHVGNQWMIFVLDMVARDFDAGTVTINLDEGAN----IAFA 292

  Fly   385 VEAYLTDPANRDRRLTTQSLSCEDEGRGRWDNGEIFFKYLRNV--------SIEGDLNKPN---I 438
            :..  |||..:|      ||:|        ...||....:..:        ||.|:::...   |
  Fly   293 LNE--TDPNCQD------SLNC--------TISEISLALVNAISKITVEEESIYGEISDEEWEAI 341

  Fly   439 EFTADGDLRSAE-LKIMN--LRPSANNKNLV-W--EEIGVW-KSWETQKLDIRDIAWPGNSHAPP 496
            .||...  :.|| |:.|.  |:.:|...:.. |  |....| ||.|.:|.
  Fly   342 RFTKQE--KQAEILEYMKEFLKTNAKCSSCARWRVETAITWGKSQENRKF--------------- 389

  Fly   497 QGVPEKFHLKITFLEEAPYINLSPADPVSGKCLMDRGVLCRVAA-----DHEMAADIDVGQAHRN 556
            :..|::......|    .:||:....||       .|.:|:..|     .|.....:|:...|..
  Fly   390 RSTPQRDAKNRNF----EFINIGYWTPV-------LGFVCQELAFPHIEHHFRNITMDILTVHNP 443

  Fly   557 ESFYQCCS-----------GFCIDLLEKFAEELGFTYELVRV----EDGKWGTLENG-KWNGLIA 605
            .  :|..:           |..::::::.:..|.|:|.|...    |:....|...| :.:.|:.
  Fly   444 P--WQILTKNSNGVIVEHKGIVMEIVKELSRALNFSYYLHEASAWKEEDSLSTSAGGNESDELVG 506

  Fly   606 DLV----NRKTDMVLTSLMINTEREAVVD--------FSEPFMETGIAIVVAKRTGIISPTAFLE 658
            .:.    .|..:||..:........|.|:        :::|......:.:..|...:.....|..
  Fly   507 SMTFRIPYRVVEMVQGNQFFIAAVAATVEDPDQKPFNYTQPISVQKYSFITRKPDEVSRIYLFTA 571

  Fly   659 PFDTASWM-LVGIVAIQAATFMIFLFEWLSPSGYDMKLYLQNTNVTPYRFSLFRTYWLVW-AVLF 721
            ||...:|. |:||:.:.|.|  ::....|:|. .:|::...:|        :...:|.:: |:|.
  Fly   572 PFTVETWFCLMGIILLTAPT--LYAINRLAPL-KEMRIVGLST--------VKSCFWYIFGALLQ 625

  Fly   722 QAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAAFMITREEFHEFSG----LNDSRLVHPF 782
            |..:::  |...:.|.:...|.:..:|.:..|..||.||:    .|.:|..    ||...
  Fly   626 QGGMYL--PTADSGRLVVGFWWIVVIVLVTTYCGNLVAFL----TFPKFQPGVDYLNQLE----- 679

  Fly   783 SHKPSFKF----GTIPYSHTDSTIHKYFNVMHNYMRQYNKTSVADGVAAVLNG---NLDSFIYDG 840
            .||...::    ||....:..||..:.|.......:.|......| :.||..|   |:|..|...
  Fly   680 DHKDIVQYGLRNGTFFERYVQSTTREDFKHYLERAKIYGSAQEED-IEAVKRGERINIDWRINLQ 743

  Fly   841 TVLDYLVAQDEDCRLMTVGSWYAMTGYGLAFSRNSKYVQMFNKRLLEFRANGDLERLRRYW---- 901
            .::.....::::|........:......:.....|.|:.:.|:.:......|.:||    |
  Fly   744 LIVQRHFEREKECHFALGRESFVDEQIAMIVPAQSAYLHLVNRHIKSMFRMGFIER----WHQMN 804

  Fly   902 --MTGTCRPGK--QEHKSSDPLALEQFLSAFLLLMAGILLAALLLLLEHVY--FKYIRKR 955
              ..|.|. ||  |...::..:.::.....||:|:.|..||.|::..|..|  |:..|||
  Fly   805 LPSAGKCN-GKSAQRQVTNHKVNMDDMQGCFLVLLLGFTLALLIVCGEFWYRRFRASRKR 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	91/447 (20%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	83/457 (18%)
		Lig_chan	665..928	CDD:278489	55/283 (19%)
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:328725	54/291 (19%)
Ir93a	NP_650924.3	Lig_chan	576..836	CDD:306551	56/287 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462910
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940