DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nmdar2 and gria1b

DIOPT Version :9

Sequence 1:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster
Sequence 2:	NP_991293.1	Gene:	gria1b / 403044	ZFINID:	ZDB-GENE-020125-2	Length:	917	Species:	Danio rerio

Alignment Length:	940	Identity:	212/940 - (22%)
Similarity:	362/940 - (38%)	Gaps:	213/940 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 HFDMMSLTP--------SPTAILSTLCKEFLRVNVSAILYMMNNEQFGHSTASAQYFLQLAGYLG 206
            |.|:..|.|        |..|:....|.:|.: .|.||:.:.:.:       :....:...|.|.
Zfish    48 HNDVPKLVPQVDMVDTGSSFAMTYAFCSQFSK-GVYAIIGLYDRK-------TMNMLMSFCGALH 104

  Fly   207 IPVI--SWNADNSGLERRASQSTLQLQLAPSIEHQSAAMLSILERYKWHQFSVVTSQIAGHDDFV 269
            :..:  |:..|        :.:...:||.|.::.   |:::::|.|||::|..:.|..:|. ..:
Zfish   105 VCFVTPSFPID--------TNNQFVIQLRPELQD---ALIALVEHYKWNKFVYMYSSDSGL-TVL 157

  Fly   270 QAVRERVAEMQEHFKFTILNSIVVTRTSDL---MELVNSEARVMLLYATQTEAITILRAAEEMKL 331
            |.:.:..||  :.::.|.:|...:|..:.|   .:|.|.:...::|........:||......|.
Zfish   158 QKILDTAAE--KTWQVTSINFDTLTEAAFLKAIQDLDNKKEFKIILDCELERLNSILNLIAAQKK 220

  Fly   332 TGENYVWVVSQSVIEKKDAHSQFPVGMLGVHF--------DTSSAALMN----EISNAI------ 378
            ..:||.::::.             :|.|.::.        :.:...|||    .:|..|
Zfish   221 NLKNYHYILAN-------------LGFLDLNLTEFRKGGANVTGFQLMNYTNPTVSRTIQDWLEF 272

  Fly   379 ----------KIYSYGVEAY--LTDPANRDRRLTTQSLSCEDEGR---------GRWDNGEIFFK 422
                      ::...|...|  :|..|...:.|..|.:.....|.         ..|..|....:
Zfish   273 DSKDLKSPKRRLKYTGALTYDGVTVMATAFQNLRKQRIDISRRGNAGECLANPPAPWGQGIDIQR 337

  Fly   423 YLRNVSIEGDLNKPNIEFTADGDLRSAELKIMNLRPSANNKNLVWEEIGVWKSWETQKLDIRDIA 487
            .|:.|..||...  :::|...|...:..:.:|...||...|      :|.|    .|:......|
Zfish   338 ALQQVQFEGLTG--HVQFNDKGHRTNFTVSVMEFGPSGPKK------VGYW----NQREKYVSTA 390

  Fly   488 WPGNSHAPPQGVPEKFHLKITFLEEAPYINLSPADPVSGKCLMDRGVLCRVAADHEMAADIDVGQ 552
            ...|......|:..:.::..|.| ||||:.|.                    .:||..    ||
Zfish   391 TYSNMLNETFGLQNRTYVVTTIL-EAPYVMLK--------------------KNHEQL----VG- 429

  Fly   553 AHRNESFYQCCSGFCIDLLEKFAEELGFTYELVRVEDGKWGT--LENGKWNGLIADLVNRKTDMV 615
               |:.:    .|:|::|..:.|:.:|::|.|..|.|||:|.  .|...|||::.:||..|.|:.
Zfish   430 ---NDKY----EGYCVELAAEIAKHVGYSYRLELVGDGKYGARDAETMMWNGMVGELVYGKADVA 487

  Fly   616 LTSLMINTEREAVVDFSEPFMETGIAIVVAKRT----GIISPTAFLEPFDTASWMLVGIVAIQAA 676
            :..|.|...||.|:|||:|||..||:|::.|.|    |:.|   ||:|.....||.: :.|....
Zfish   488 VAPLTITLVREEVIDFSKPFMSLGISIMIKKPTKSKPGVFS---FLDPLAYEIWMCI-VFAYIGV 548

  Fly   677 TFMIFLFEWLSPSGY-----DMKLYLQNTNVTP--------------------------YRFSLF 710
            :.::||....||..:     :.....||.|..|                          ..|.:|
Zfish   549 SVVLFLVSRFSPYEWHADDEEETADQQNQNQPPSPEPNQSPNQSQNQREEKQEKQPEHTNEFGIF 613

  Fly   711 RTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAAFMITREEFHEFSGLND 775
            .:.|.......|....: |||..:.|.:..||..|.::.::.||||||||            |..
Zfish   614 NSLWFSLGAFMQQGCDI-SPRSLSGRIVGGVWWFFTLIIISSYTANLAAF------------LTV 665

  Fly   776 SRLVHP------FSHKPSFKFGTIPYSHTDSTIHK----YFNVMHNYMRQYNKT----SVADGVA 826
            .|:|.|      .:.:....:||:....|.....:    .|..|.:||:....|    :..:||.
Zfish   666 ERMVSPIESAEDLAKQTEIAYGTLDGGSTKEFFRRSKIAVFEKMWSYMKSAEPTVFVKTTDEGVV 730

  Fly   827 AVLNG-NLDSFIYDGTVLDYLVAQDEDCRLMTVGSWYAMTGYGLAFSRNSKYVQMFNKRLLEFRA 890
            .|... ...:::.:.|:.:| :.|.:.|..|.||......|||:|..:.|......|..:|:...
Zfish   731 RVRKSKGKYAYLLESTMNEY-IEQRKPCDTMKVGGNLDSKGYGVATPKGSALRNPVNLAVLKLNE 794

  Fly   891 NGDLERLRRYWM--TGTCRPGKQEHK-SSDPLALEQFLSAFLLLMAGILLAALLLLLEHVYFKYI 952
            .|.|::|:..|.  .|.|..|..:.| .:..|:|......|.:|:.|:.||.|:.|:|..|...|
Zfish   795 QGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALVEFCYKSRI 859

  Fly   953 RKRLAKKDGGHCCALISLSM-GKSLTFRGA 981
            ..|..|:       :|..:| ..:||..|:
Zfish   860 ESRRMKQ-------IIDAAMLSSTLTRMGS 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	71/391 (18%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	118/459 (26%)
		Lig_chan	665..928	CDD:278489	69/311 (22%)
gria1b	NP_991293.1	PBP1_iGluR_AMPA_GluR1	26..387	CDD:107385	70/385 (18%)
		ANF_receptor	41..368	CDD:279440	63/356 (18%)
		PBP2_iGluR_AMPA_GluR1	404..812	CDD:270447	117/458 (26%)
		Lig_chan	536..842	CDD:278489	71/320 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591496
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.740