DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar2 and clumsy

DIOPT Version :9

Sequence 1:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster
Sequence 2:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster

Alignment Length:	838	Identity:	203/838 - (24%)
Similarity:	337/838 - (40%)	Gaps:	166/838 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   188 FGHST-ASAQYFLQLAGYLGIP--VISWNADNSGLERRASQSTLQLQLAPSIEHQSAAMLSILER 249
            ||.|| :|:.....:...|.||  |..|..:.|..:|  ..||:.|.:.|.....|..:..|::.
  Fly    89 FGPSTGSSSDIIASICDTLDIPHIVYDWIPNESIPDR--EHSTMTLNVHPDNLLLSQGLAEIVQS 151

  Fly   250 YKWHQFSVV---TSQIAGHDDFVQAVRERVAEM---------QEHFKFTILNSIVVTRTSDLMEL 302
            :.|..|:||   ..::....|.:| |.|.::..         .:|..|             |.|:
  Fly   152 FAWRSFTVVYETDKELQQLQDILQ-VGEPISNPTTVKQLGPGDDHRPF-------------LKEI 202

  Fly   303 VNSEARVMLLYATQTEAITILRAAEEMKLTGENYVWVVSQSV-IEKKDAHSQFPVGML-GVHFDT 365
            ..|....::|:......:.||:.|.|:|:.||      .||| |...|.|| ...|.| ||..:.
  Fly   203 KLSTDNCLILHCAPDNLLKILQQANELKMLGE------YQSVFIPLLDTHS-IDFGELSGVEANI 260

  Fly   366 SSAALMNEISNAIKIYSYGVEA--------YLTDPANRDRRLTTQSLSCEDEGRGRWDNGEIFFK 422
            ::..||:.....:|...:..|.        :..||    .|:.:|.:...|   ..|    :|.|
  Fly   261 TTVRLMDPSDFHVKNVVHDWEEREKREGRYFKVDP----NRVKSQMILLND---AVW----LFSK 314

  Fly   423 YLRNVSIEGDLNKPNIEFTADGDLRSAELKIMNLRPSANNKNLVWEEIGVWKSWETQ--KLDIRD 485
            .|..:.|..:|..|::|             ....:|....|.::  |....:|.||.  ::|..:
  Fly   315 GLTELGIFEELTAPDLE-------------CRRKKPWPFGKRII--EFIKARSEETSTGRIDFNE 364

  Fly   486 IAWPGNSHAPPQGVPEKFHLKITFLEEAPYINLSPADPVSGKCLMDRGVLCRVAADHEMAADIDV 550
                       .|....|.|:...|....:::|:..|||:|   :|      |..|.| .::..|
  Fly   365 -----------NGQRSFFTLRFMELNSDGFLDLATWDPVNG---LD------VLNDDE-ESEKRV 408

  Fly   551 GQAHRNESF---------------------------YQCCSGFCIDLLEKFAEELGFTYELVRVE 588
            ||...|::|                           |:   |:.|||:.:.|:.|.|.:|.....
  Fly   409 GQKLSNKTFIVSSRLGAPFLTLREPQEGEILTGNSRYE---GYSIDLINEIAKMLNFKFEFRMSP 470

  Fly   589 DGKWGTLE--NGKWNGLIADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGIAIVVAKRTGII 651
            |||:|.|.  ...|:|::..|::...|:.:..|.:.:.|...|||:.|||..||:|:.:|
  Fly   471 DGKYGALNKVTQTWDGIVRQLIDGNADLGICDLTMTSSRRQAVDFTPPFMTLGISILFSK----- 530

  Fly   652 SPT------AFLEPFDTASWMLVGIVAIQAATFMIFLFEWLSPSGYDMKLYLQNTNVTPYRFSLF 710
            .||      :||.||....|:.:| .|....:.::|....::|..::.....:........:|:.
  Fly   531 PPTPPTDLFSFLSPFSLDVWIYMG-SAYLFISLLLFALARMAPDDWENPHPCKEPEEVENIWSIM 594

  Fly   711 RTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAAFMITREEFHEFSGLND 775
            .|.||....|......: .|:..::|.:|.:|..||::.|..||||||||:....:.:..:...|
  Fly   595 NTTWLSIGSLMGQGCDI-LPKAASTRLVTGMWWFFALMMLNSYTANLAAFLTNSRQANSINSAED 658

  Fly   776 SRLVHPFSHKPSFKFGTIPYSHT--------DSTIHKYFNVMHNYMRQ-YNKTSVADGVAAVLNG 831
                  .:.:...|:|.:....|        .||..|.:..|.:.... :.||: .:||..|..|
  Fly   659 ------LAAQSKIKYGAMAGGSTMGFFRDSNFSTYQKMWTAMESASPSVFTKTN-DEGVERVQKG 716

  Fly   832 -NLDSFIYDGTVLDYLVAQDEDCRLMTVGSWYAMTGYGLAFSRNSKYVQMFNKRLLEFRANGDLE 895
             ||.:|:.:.|.|:|.|  :..|.|:.:|.|.....||:|...||.|.:..:..:|:....|.|.
  Fly   717 KNLYAFLMESTTLEYNV--ERKCDLVQIGGWLDYKSYGIAMPFNSPYRKQISAAVLKLGELGQLA 779

  Fly   896 RLRRYWMT-----GTCRPGKQEHKSSDPLALEQFLSAFLLLMAGILLAALLLLLEHVY 948
            .|:|.|..     |.|....::...:..|.||.....||:|..|:|.|.:|...|.::
  Fly   780 ELKRKWWKEMHGGGNCEKSDEDGGDTPELGLENVGGVFLVLGLGLLSAMVLGCTEFLW 837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	74/328 (23%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	117/455 (26%)
		Lig_chan	665..928	CDD:278489	67/277 (24%)
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	83/369 (22%)
		ANF_receptor	39..379	CDD:279440	77/349 (22%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	100/391 (26%)
		Lig_chan	548..812	CDD:278489	66/274 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462664
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	169	1.000	Inparanoid score	I1556
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.890