Protein Alignment Nmdar2 and GluRIIB

DIOPT Version :9

• Sequence 1: NP_001014714.1
• Gene: Nmdar2 / 31107
• FlyBaseID: FBgn0053513
• Length: 1083
• Species: Drosophila melanogaster
• Sequence 2: NP_523485.3
• Gene: GluRIIB / 33789
• FlyBaseID: FBgn0020429
• Length: 913
• Species: Drosophila melanogaster
• Alignment Length: 958
• Identity: 209/958 - (21%)
• Similarity: 375/958 - (39%)
• Gaps: 203/958 - (21%)

  Fly    89 SLSKGAAANKEQL--NIGLIAPHTNF-------GKREYLRSINNAVTGLTKTRGAKLTFLKDYSF 144
            :|:..:.||::.|  .||.|...|..       ...|.:.:||.|:         ||..:|.|
  Fly    11 ALAIASGANEDTLVIKIGAIFFDTEMKLADAFSAALEEVNAINPAL---------KLDAIKRY-- 64

  Fly   145 EQKNIHFDMMSLTPSPTAILSTLCKEFLRVNVSAILYMMNNEQFGHSTASAQYFLQ-LAGYLGIP 208
                       :|...:.:|..:..:.:...|:||        ||.|:.:....:: |....|||
  Fly    65 -----------VTVDDSIVLQDISCDLIGSGVAAI--------FGPSSKTNSDIVEVLCNMTGIP 110

  Fly   209 VI--SWNADNSGLERRASQSTLQLQLAPSIEHQSAAMLSIL--ERYKWHQFSVVTSQIAGHDDFV 269
            .:  .|:...|..||...|  |.:.:||.....|||...||  :.:.|..|::...: :.|...:
  Fly   111 HLQFDWHPQQSNRERMNHQ--LTVNVAPMELFLSAAFSDILASKTFDWKSFTIAYER-SSHLIRL 172

  Fly   270 QAV------RERVAEMQEHFK---FTILNSIVVTRTSDLMELVNSEARVMLLYATQTEAITILRA 325
            |.:      .:...:|||..:   :.||          ...:.|:..:.:||.......:.::.|
  Fly   173 QHILAWKQLHKAGIKMQEFERGDDYRIL----------WKRINNAREKFVLLDCPSDILVDVINA 227

  Fly   326 AEEMKLTGE-NYVWVVSQSVIEKKDAH---------SQFPVGMLGVH---------------FDT 365
            :....:||. |::::.:      .|.|         ..|.|.:..|.               ||.
  Fly   228 SIGYNMTGSFNHLFLTN------LDTHLSGIDGFYSRDFTVAVAAVRIRTYVPPPVHDEIDVFDN 286

  Fly   366 SSAALMNEISNAIKIYSYGVEAY--LTDPANRDRRLTTQSLSCEDEGRGRWDNGEIFFKYLRNVS 428
            |.....:.:.:.: :|...|..|  |.:.:.|. .....:.||   |||.|..|....:.::.::
  Fly   287 SVDTRFSSLGSQL-VYDSIVLFYNALLEISQRP-GFYIPNFSC---GRGFWQPGPRLVEQMKQIT 346

  Fly   429 ---IEGDLNKPNIEFTADGDLRSAELKIMNLRPSANNKNLVWEEIGVWKSWETQKLDIRDIAWPG 490
               ::.......::..|||......|::.|  |..:....:|.:       |.|.:|...:.  .
  Fly   347 PKMVKPPFKTQRLQINADGQREDFNLEVYN--PIIDRVTHIWNK-------EFQLVDFEKLR--E 400

  Fly   491 NSHAPPQGVPEKFHLKITFLEEAPYINLSPADPVSGKCLMDRGVLCRVAADHEMAADIDVGQAHR 555
            ||   .|.:.:|              .|...:..|.|.:. ..|..||...:....:...|..:.
  Fly   401 NS---TQALKQK--------------RLQNKEDFSQKPIR-YTVATRVGKPYFSWREEPEGVHYE 447

  Fly   556 -NESFYQCCSGFCIDLLEKFAEELGFTYELVRVEDGKWGTLE--NGKWNGLIADLVNRKTDMVLT 617
             ||.|    .|:.:||:...|:|..|.:....|.|.|:|:.:  ..:|:|:|..|::....:.:.
  Fly   448 GNERF----EGYAVDLIYMLAQECKFDFNFEPVRDNKYGSYDANTDEWDGIIRQLIDNNAQIGIC 508

  Fly   618 SLMINTEREAVVDFSEPFMETGIAIVVAK----RTGIISPTAFLEPFDTASWMLVGIVAIQAATF 678
            .|.|...|.:||||:.|||:.||:|:..|    :..|.   |||.|::...|:.|.|..:..|..
  Fly   509 DLTITQARRSVVDFTVPFMQLGISILSYKEPPPKADIY---AFLNPYNAEVWLFVMIAMMITAFA 570

  Fly   679 MIFL-----FEWLSPSGYDMKLYLQNTNVTPYR---FSLFRTYWLVWAVLFQAAVHVDSPRGFTS 735
            :||.     :||..|        ::|.|....|   :.|....|||...:......: .|||...
  Fly   571 LIFTGRIDQYEWDQP--------VENVNREMERQNIWHLSNALWLVLGSMLNQGCDL-LPRGLPM 626

  Fly   736 RFMTNVWALFAVVFLAIYTANLAAFMITREEFHEFSGLNDSRLVHPFSHKPSFKFGTIP------ 794
            |.:|..|.:||::....|.|.||||:.:.:...:...|:|  ||    .:...:||||.
  Fly   627 RLLTAFWWIFALLISQTYIAKLAAFITSSKIAGDIGSLHD--LV----DQNKVQFGTIRGGATSV 685

  Fly   795 -YSHTDSTIHKY-FNVMHNYMRQYNKTSVADGVAAV-LNGNLDSFIYDGTVLDYLVAQDEDCRLM 856
             :|.::.|.::. :|.|.::.......:..:||..| |:....:|:.:.|.|.|.|  ..:|.|.
  Fly   686 YFSESNDTDNRMAWNKMLSFKPDAFTKNNEEGVDRVKLSKGTYAFLMETTNLQYYV--QRNCELT 748

  Fly   857 TVGSWYAMTGYGLAFSRNSKYVQMFNKRLLEFRANGDLERLRRYWMT---GTCRPGKQEHKSSDP 918
            .:|..:....||:|...|:.:....:..:|.....|:|.:||..|..   .||       .|:.|
  Fly   749 QIGESFGEKHYGIAVPLNADFRSNLSVGILRLSERGELFKLRNKWFNSNESTC-------DSNVP 806

  Fly   919 ------LALEQFLSAFLLLMAGILLAALLLLLEHVYFKYIRKRLAKKD 960
                  ..::.....|::|:.|:::..::.:.|   |.:..:|::.|:
  Fly   807 TIDDGQFDMDSVGGLFVVLIVGVVVGLVIGVAE---FLWHVQRISVKE 851

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	84/443 (19%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	110/432 (25%)
		Lig_chan	665..928	CDD:278489	68/288 (24%)
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	82/429 (19%)
		ANF_receptor	41..378	CDD:279440	74/392 (19%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	104/397 (26%)
		Lig_chan	555..822	CDD:278489	68/290 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462662
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840