Protein Alignment Nmdar2 and Ir25a

DIOPT Version :9

• Sequence 1: NP_001014714.1
• Gene: Nmdar2 / 31107
• FlyBaseID: FBgn0053513
• Length: 1083
• Species: Drosophila melanogaster
• Sequence 2: NP_001260049.1
• Gene: Ir25a / 33683
• FlyBaseID: FBgn0031634
• Length: 947
• Species: Drosophila melanogaster
• Alignment Length: 1099
• Identity: 232/1099 - (21%)
• Similarity: 411/1099 - (37%)
• Gaps: 318/1099 - (28%)

  Fly    52 ILTPPSGPISLLLLTVLTLLILDTRSCQGLRLTNGGGSLSKGAAANKEQLNIGLIAPHTNFGKRE 116
            ||..|.....|.||..|:||                .|.|...||...| ||.::
  Fly     2 ILMNPKTSKILWLLGFLSLL----------------SSFSLEIAAQTTQ-NINVL---------- 39

  Fly   117 YLRSINNAVTGLTKTRGAKLTFLKDYSFEQKNIHFDMMSLTPSPTA-------ILSTLCKEFLRV 174
            ::..::|...  .|.....||:||      |||.:.:.....|..|       :|..:|.::
  Fly    40 FINEVDNEPA--AKAVEVVLTYLK------KNIRYGLSVQLDSIEANKSDAKVLLEAICNKY--- 93

  Fly   175 NVSAI------LYMMNNEQFGHSTASAQYFLQLAGYLGIPVISWNADNSGLERR------ASQST 227
             .::|      ..:::..:.|.::.:.:.|.|.   ||:|.||.:....|..|:      |.|..
  Fly    94 -ATSIEKKQTPHLILDTTKSGIASETVKSFTQA---LGLPTISASYGQQGDLRQWRDLDEAKQKY 154

  Fly   228 LQLQLAPSIEHQSAAMLSILERYKWHQFSVVTSQIAGHDDFVQAVRERVAEMQEHFKFTILNSI- 291
            | ||:.|..:....|:.||:     ...::..:.|...|.||         |...:| ::|.:|
  Fly   155 L-LQVMPPADIIPEAIRSIV-----IHMNITNAAILYDDSFV---------MDHKYK-SLLQNIQ 203

  Fly   292 ---VVT---------RTSDLMELVNSEARVMLLYATQTEAITILRAAEEMKLTGENYVW-VVSQS 343
               |:|         |...:.:|.|.:.....:..| .::|.::..:.:......|:.| .::|:
  Fly   204 TRHVITAIAKDGKREREEQIEKLRNLDINNFFILGT-LQSIRMVLESVKPAYFERNFAWHAITQN 267

  Fly   344 ---VIEKKD----------AHSQF--PVGMLGVHFDTSSAALMNE---ISNAIKIYSYGVEAYLT 390
               :..::|          |::|:  .:|:|...::      :||   :|:|. .:...:.::||
  Fly   268 EGEISSQRDNATIMFMKPMAYTQYRDRLGLLRTTYN------LNEEPQLSSAF-YFDLALRSFLT 325

  Fly   391 D---------PANRDRRLTTQSLSCED-----------------------EGRGRWD-------- 415
            .         |.:      .:.|:|:|                       ...|.:|
  Fly   326 IKEMLQSGAWPKD------MEYLNCDDFQGGNTPQRNLDLRDYFTKITEPTSYGTFDLVTQSTQP 384

  Fly   416 -NGEIFFKYLRNVSIEGDLNKPNIEFTADGDLRSAELKIMNLR--PSANNKNLVWEEIGVWKSWE 477
             ||..|.|:      |.|:|                  ::.:|  .|.|:|:     ||.|.|..
  Fly   385 FNGHSFMKF------EMDIN------------------VLQIRGGSSVNSKS-----IGKWISGL 420

  Fly   478 TQKLDIRDIAWPGNSHAPPQGVPEKFHLKITFLEEAPYINLSPADPVSGKCLMDRGVLCRVAADH 542
            ..:|.::|.....|..|...       .:|..:.:||:|
  Fly   421 NSELIVKDEEQMKNLTADTV-------YRIFTVVQAPFI-------------------------- 452

  Fly   543 EMAADIDVGQAHRNESFYQCCSGFCIDLLEKFAEELGFTYELVRVEDGKWGTL-ENGKWNGLIAD 606
                       .|:|:..:...|:||||:.:.|..:.|.|.:..|||||:|.: |||:|||::..
  Fly   453 -----------MRDETAPKGYKGYCIDLINEIAAIVHFDYTIQEVEDGKFGNMDENGQWNGIVKK 506

  Fly   607 LVNRKTDMVLTSLMINTEREAVVDFSEPFME-TGIAIVVAKRTGIISPTAFLEPFDTASWMLVGI 670
            |::::.|:.|.|:.:..|||.|:||:.|:.: .||.|::.:.:...|...||...:|..|:.: :
  Fly   507 LMDKQADIGLGSMSVMAEREIVIDFTVPYYDLVGITIMMQRPSSPSSLFKFLTVLETNVWLCI-L 570

  Fly   671 VAIQAATFMIFLFEWLSPSGYDMKLYLQNTNVTPYR-------FSLFRTYWLVWAVLFQAAVHVD 728
            .|....:|::::|:..||..|      || |...|:       |:|....|.....|.... ..:
  Fly   571 AAYFFTSFLMWIFDRWSPYSY------QN-NREKYKDDEEKREFNLKECLWFCMTSLTPQG-GGE 627

  Fly   729 SPRGFTSRFMTNVWALFAVVFLAIYTANLAAFMITREEFHEFSGLNDSRLVHPFSHKPSFKFGTI 793
            :|:..:.|.:...|.||..:.:|.||||||||:...........|:|....:...:.|......:
  Fly   628 APKNLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQYKILYAPLNGSSAM 692

  Fly   794 PYSHTDSTIHKYF--------------------------NVMHNYMRQYNKTSVA-------DGV 825
            .|....|.|.:.|                          .|...|.:.:.....|       :.|
  Fly   693 TYFERMSNIEQMFYEIWKDLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAMQEAKLPATLDEAV 757

  Fly   826 AAVLNGNLD---SFIYDGTVLDYLVAQDEDCRLMTVGSWYAMTGYGLAFSRNSKYVQMFNKRLLE 887
            |.|.|....   :|:.|.|.:.||  |..:|.|..||..::...|.:|..:.|.....||..:|.
  Fly   758 ARVRNSTAATGFAFLGDATDIRYL--QLTNCDLQVVGEEFSRKPYAIAVQQGSHLKDQFNNAILT 820

  Fly   888 FRANGDLERLRRYW-----MTGTC-RPGKQEHKSSDPLALEQFLSAFLLLMAGILLAALLLLLEH 946
            ......||:|:..|     ....| :|..|    ||.::::.....|:::..||.:|.:.|:.|:
  Fly   821 LLNKRQLEKLKEKWWKNDEALAKCDKPEDQ----SDGISIQNIGGVFIVIFVGIGMACITLVFEY 881

  Fly   947 VYFKY--------IRKRLAKKDGG--HCCALISLSMGKSLTFRGAVFEATEILKKHRCN 995
            .:::|        :.:..|::...  |...|:.   |..|...|..||.::...:.|.|
  Fly   882 WWYRYRKNPRIIDVAEANAERSNAADHPGKLVD---GVILGHSGEKFEKSKAALRPRFN 937

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	88/484 (18%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	108/456 (24%)
		Lig_chan	665..928	CDD:278489	68/311 (22%)
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	84/459 (18%)
		PBP2_iGluR_putative	438..836	CDD:270435	107/452 (24%)
		Lig_chan	565..870	CDD:278489	69/319 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45463097
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	169	1.000	Inparanoid score	I1556
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.890