DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nmdar2 and Ir21a

DIOPT Version :9

Sequence 1:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster
Sequence 2:	NP_001097043.1	Gene:	Ir21a / 33157	FlyBaseID:	FBgn0031209	Length:	842	Species:	Drosophila melanogaster

Alignment Length:	513	Identity:	99/513 - (19%)
Similarity:	178/513 - (34%)	Gaps:	116/513 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   570 LLEKFAEELGFTYELVRVEDGKWGTLEN--GKWNGLIADLVNRKTDMVLTSLMINTEREAVVDFS 632
            ||...::.|.|:.::....     |..|  |..:.:...::.|..|:.::.:.|..||     ..
  Fly   316 LLTMISKRLNFSIDITETP-----TRSNTRGVVDTIQEQIIERTVDIGMSGIYITQER-----LM 370

  Fly   633 EPFMETG-----IAIVVAKRTGIISPTAFLEPFDTASWMLVGIVAIQAATFMIFLFEWLSPSGYD 692
            :..|..|     .|.:......:....|.:.||....|:.: |.......|.|...:.|:.| :.
  Fly   371 DSAMSVGHSPDCAAFITLASKALPKYRAIMGPFQWPVWVAL-ICVYLGGIFPIVFTDRLTLS-HL 433

  Fly   693 MKLYLQNTNVTPYRFSLFRTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANL 757
            |..:.:..|:..|.|.:|..     |..|.......:.|..::|.:...:.||.::..:.||.::
  Fly   434 MGNWGEVENMFWYVFGMFTN-----AFSFTGKYSWSNTRKNSTRLLIGAYWLFTIIITSCYTGSI 493

  Fly   758 AAFMI------TREEFHEFSGLNDSRLVHPFSHKPSFKFGTIPYSHTDSTIHKYFNVMHNYMRQY 816
            .||:.      |.:...:..||             .|:.||:.....::......::..:  |.|
  Fly   494 IAFVTLPAFPDTVDSVLDLLGL-------------FFRVGTLNNGGWETWFQNSTHIPTS--RLY 543

  Fly   817 NKT----SVADGVAAVLNGNLDSFIYDGT--VLDYLVAQD---------------EDCRLMTVGS 860
            .|.    ||.:|:..|......::.:.|:  .|:|||..:               |:|
  Fly   544 KKMEFVGSVDEGIGNVTQSFFWNYAFLGSKAQLEYLVQSNFSDENISRRSALHLSEEC------- 601

  Fly   861 WYAMTGYGLAFSRNSKYVQMFNKRLLEFRANGDLERLRR--YWMTGTCRPGKQEHKSSDPLALE- 922
             :|:...|..|.|.|.|....:..:|..:.:|.:.::..  .|:......|:....||.....|
  Fly   602 -FALFQIGFLFPRESVYKIKIDSMILLAQQSGLIAKINNEVSWVMQRSSSGRLLQASSSNSLREI 665

  Fly   923 -----QFLSA-----FLLLMAGILLAALLLLLEHV-----YFKYIRKRLAKKDGGHCCALISLSM 972
                 |..:|     |||:..|..|.|..|:.|.|     ..:.|.||..|....   :..|.|.
  Fly   666 IQEERQLTTADTEGMFLLMALGYFLGATALVSEIVGGITNKCRQIIKRSRKSAAS---SWSSASS 727

  Fly   973 GKSLTFRGAVF----------EATEILKKHRCNDPICDTHLWKVKHELDMSRLRVRQL 1020
            |..|.......          ||.|:.:|....           ..||:::|..:|::
  Fly   728 GSMLRTNAEQLSHDKRKANRREAAEVAQKMSFG-----------MRELNLTRATLREI 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	68/373 (18%)
		Lig_chan	665..928	CDD:278489	56/302 (19%)
Ir21a	NP_001097043.1	Periplasmic_Binding_Protein_Type_2	289..583	CDD:304360	57/298 (19%)
Ir21a	NP_001097043.1	Lig_chan	407..662	CDD:278489	53/284 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910