DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar2 and Ir8a

DIOPT Version :9

Sequence 1:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster
Sequence 2:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster

Alignment Length:	962	Identity:	213/962 - (22%)
Similarity:	346/962 - (35%)	Gaps:	262/962 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 TVLTLLILDTRSCQGLRLTNGGGSLSK-GAAANKEQLNIGLIAPHTNFGKREYLRSINNAVTGLT 129
            |.|||    |||..||.:......||. ||:|     .|.|...|...| ...:||:......|.
  Fly    57 TTLTL----TRSEDGLDMQRFCEILSTVGASA-----VIDLTYSHWEEG-YNLVRSLGIGYVRLE 111

  Fly   130 KTRGAKLTFLKDYSFEQK--NIHFDMMSLTPSPTAILSTLCKEFLRVNVSAILYMMNNEQFGHST 192
            :.....|....|:..:::  |:....|:...:..|:...|      |.......:|:..|    |
  Fly   112 RIMRPFLDMFGDFMRQKRANNVAMVFMNARDAVEAMQQML------VGYPFRTLIMDASQ----T 166

  Fly   193 ASAQYFLQLAGYLGIPVISWNADNSGLERRASQSTLQLQLAP---SIEHQSAAMLSILER----- 249
            ...|:|                    |||..|     |:.||   ::..::|||..|.|:
  Fly   167 DPGQHF--------------------LERIRS-----LRPAPTYIALFARAAAMNGIFEKVQKAD 206

  Fly   250 -----YKWHQFSVVTSQIAGHDDFVQAVRERV------AEMQEHFKFTILNSIVVTRTSDLMELV 303
                 .:||...:.|             |:||      ||:...|   .||...:.|:..:.:|.
  Fly   207 LFQRPLEWHFVFLDT-------------RDRVFKYRRQAELCTRF---TLNPRAICRSMPMPDLY 255

  Fly   304 NSEA----RVMLLYATQTEAITILRAAEEMKLTGENYVWVVSQSVIEKKDAHSQFPVGMLGVHFD 364
            ....    |.|||        .:||                  |:|........:|   |.::.|
  Fly   256 CGSGFTMQRAMLL--------NVLR------------------SLINAAQVSPGYP---LAIYQD 291

  Fly   365 TSSAALMNEISNAIKIYSYGVEAYLTDPANRDRRLTTQSLSCEDEGRGRWDNGEIFFKYLRNVSI 429
            .::.|..:|:|               ||..:|.......:        .|.|...:...|.::..
  Fly   292 CNATASSSEVS---------------DPLEKDDYNWLDMV--------HWSNFLAYAPPLPHIQD 333

  Fly   430 EGDLNKPNIEFTADGDLRSAELKIMNLRPSANNKNLVWEEIGVWKSWETQKLDIRDIAWPGNSHA 494
            :.....|.:.|.            :|:            ..|.:.|....|.|:  .||
  Fly   334 QFQSPVPGLTFA------------VNI------------SAGYYSSEHEAKTDL--AAW------ 366

  Fly   495 PPQGVPEKFHLKITFLEEAPYINLSPADPVSGKCL-MDRGVLCRVAADHEMAADIDVGQAHRNES 558
              ..|.|...|..|......:..:..|:.:....| .:.|                .|:..|:.|
  Fly   367 --SSVGEMRLLNETISPARRFFRIGTAESIPWSYLRREEG----------------TGELIRDRS 413

  Fly   559 FYQCCSGFCIDLLEKFAEELGFTYELVRVEDGKWGTL-ENGKWNGLIADLVNRKTDMVLTSLMIN 622
            ......|:|||.:.:.:::|.|.:|:|..|.|..|.| |.|:|:|::.|||..:||..:.:|.:.
  Fly   414 GLPIWEGYCIDFIIRLSQKLNFEFEIVAPEVGHMGELNELGEWDGVVGDLVRGETDFAIAALKMY 478

  Fly   623 TEREAVVDFSEPFME-TGIAIVVAKRTGIISPTAFLEPFDTASWMLVGIVAIQAATFMIFLFEWL 686
            :|||.|:||..|:.| |||:|.:.|.....|...|:.......|:.: :.|:.....||:..:..
  Fly   479 SEREEVIDFLPPYYEQTGISIAIRKPVRRTSLFKFMTVLRLEVWLSI-VAALVGTAIMIWFMDKY 542

  Fly   687 SPSGYDMKLYLQNTNVTPY---RFSLFRTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVV 748
            ||  |..:   .|....||   .|:|..::|.. ...|......::|:..:.|.:...:.||.|:
  Fly   543 SP--YSSR---NNRQAYPYACREFTLRESFWFA-LTSFTPQGGGEAPKAISGRMLVAAYWLFVVL 601

  Fly   749 FLAIYTANLAAFMITREEFHEFSGLNDSRLVHPF-SHKPSFKFGTIPYSHT-DSTIHKYF----- 806
            .||.:|||||||            |...|:..|. |.:...:...|.|:.. ||..|:||
  Fly   602 MLATFTANLAAF------------LTVERMQTPVQSLEQLARQSRINYTVVKDSDTHQYFVNMKF 654

  Fly   807 --------------NVMHNYMR----------QY--------NKTSVAD---GVAAV-LNGNLD- 834
                          |...::.:          ||        :...|||   |.|.| .:.|.|
  Fly   655 AEDTLYRMWKELALNASKDFKKFRIWDYPIKEQYGHILLAINSSQPVADAKEGFANVDAHENADY 719

  Fly   835 SFIYDGTVLDYLVAQDEDCRLMTVGSWYAMTGYGLAFSRNSKYVQMFNKRLLEFRANGDLERLR- 898
            :||:|...:.|.:.:  :|.|..||..:|...|.:|..:.|......:..:||.:.:...|.|:
  Fly   720 AFIHDSAEIKYEITR--NCNLTEVGEVFAEQPYAVAVQQGSHLGDELSYAILELQKDRFFEELKA 782

  Fly   899 RYWMTGTCRPGKQEHKSSDPLALEQFLSAFLLLMAGILLAALLLLLEHVYFK 950
            :||..... |.....:..:.:.||.....|:..:.|::||.:.|.:|.:|:|
  Fly   783 KYWNQSNL-PNCPLSEDQEGITLESLGGVFIATLFGLVLAMMTLGMEVLYYK 833

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	73/415 (18%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	113/456 (25%)
		Lig_chan	665..928	CDD:278489	71/310 (23%)
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	110/439 (25%)
Ir8a	NP_727328.1	Lig_chan	520..818	CDD:278489	72/319 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910