DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar2 and Ir7c

DIOPT Version :9

Sequence 1:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster
Sequence 2:	NP_001245572.1	Gene:	Ir7c / 31692	FlyBaseID:	FBgn0029966	Length:	625	Species:	Drosophila melanogaster

Alignment Length:	500	Identity:	101/500 - (20%)
Similarity:	189/500 - (37%)	Gaps:	97/500 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   484 RDIAWPGNSHAPPQGV-PEKF------HLKITFLEEAPYINL--SPADPVSGKCLMDRGVLCRVA 539
            :|:|.|.|.....:.: |.|.      .:.:...|..||:.:  .|..| .|:.:
  Fly   188 QDLAAPANGFGLTKPLFPRKLTNMHGCEMVVATFEHRPYVIIEDDPKTP-GGRSI---------- 241

  Fly   540 ADHEMAADIDVGQAHRNESFYQCCSGFCIDLLEKFAEELGFTYELVRVEDGKWG-TLENGKWNGL 603
                          |..|..          :....||.:.||.:||..:|...| .|.:|.:.|:
  Fly   242 --------------HGIEGL----------IFRSLAERMNFTIKLVEQKDKNRGEILPDGNFTGI 282

  Fly   604 IADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGIAIVVAKRTGIISPTAFL-EPFDTASWML 667
            :..:|:.:.::.....|.:..|..::..|..:....|.:||.. .|.|||...| .||....|..
  Fly   283 LKMMVDGEVNLTFVCFMYSKARSDLMLPSTSYTSFPIVLVVPS-GGSISPMGRLTRPFRYIIWSC 346

  Fly   668 VGIVAIQAATFMIFLFEWLSPSGYDMKLYLQNTNVTPYRFSLFRTYWLVWAVLFQAAVHVDSPRG 732
            : :|::.....:|.|.:..:..|. ..|.|...|..|:..        :||.|.......:..|.
  Fly   347 I-LVSLIFGFVLICLLKITALPGL-RNLVLGRRNRLPFMG--------MWASLLGGLALYNPQRN 401

  Fly   733 FTSRFMTNVWALFAVVFLAIYTANLAAFMITREEFHEFSGLNDSRLVHPFSH-----KPSFKFGT 792
            | :|::..:|.|..::..|.||..|  :::          |.|..:..|...     ...::|..
  Fly   402 F-ARYILVMWLLQTLILRAAYTGQL--YLL----------LQDVEMRSPIKSLSEVLAKDYEFRI 453

  Fly   793 IPYSHT---DS----TIHKYFNVMHNYMRQYNKTSVADGV-AAVLNGNLDSFIY-DGTVLDYLVA 848
            :|...|   ||    ..|...::..:..|..::..  .|: .|:|...::.|.: .|....:|..
  Fly   454 LPALRTIFKDSMPTTNFHAVLSLEESLYRLRDEDD--PGITVALLQPTVNQFDFRSGPNKRHLTV 516

  Fly   849 QDEDCRLMTVGSWYAMTGYGLAFSRNSKYVQMFNKRLLEFRANGDLERLRRYWMTGTCRPGKQEH 913
            ..:.  |||....:.|..:       |.:.:..::.::...::|.:.|.|:.:|....|..|:.:
  Fly   517 LPDP--LMTAPLTFYMRPH-------SYFKRRIDRLIMAMMSSGIVARYRKMYMDRIKRVSKRRN 572

  Fly   914 KSSDPLALEQFLSAFLLLMAGILLAALLL-LLEHVYFKYIRKRLA 957
            ....||::.: ||...:..||:.|.||:: :||.:...:.|.|.|
  Fly   573 LEPKPLSIWR-LSGIFVCCAGLYLVALIVFILEILTTNHRRLRRA 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	2/5 (40%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	80/429 (19%)
		Lig_chan	665..928	CDD:278489	52/276 (19%)
Ir7c	NP_001245572.1	Lig_chan-Glu_bd	225..287	CDD:214911	18/96 (19%)
Ir7c	NP_001245572.1	Lig_chan	343..593	CDD:278489	53/284 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45463020
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740