Protein Alignment Nmdar2 and Gria3

DIOPT Version :10

• Sequence 1: NP_001014714.1
• Gene: Nmdar2 / 31107
• FlyBaseID: FBgn0053513
• Length: 1083
• Species: Drosophila melanogaster
• Sequence 2: NP_116785.2
• Gene: Gria3 / 29628
• RGDID: 70958
• Length: 888
• Species: Rattus norvegicus
• Alignment Length: 902
• Identity: 209/902 - (23%)
• Similarity: 350/902 - (38%)
• Gaps: 226/902 - (25%)

  Fly   148 NIHFDMMSLTPSPTAILSTLCKEFLRVNVSAILYMMNNEQFG-HSTASAQYFLQLAGYLGIPVI- 210
            |.|.|.:..:.| .::.:..|.:|.| .|.||        || :...|........|.|....:
  Rat    66 NYHVDHLDSSNS-FSVTNAFCSQFSR-GVYAI--------FGFYDQMSMNTLTSFCGALHTSFVT 120

  Fly   211 -SWNADNSGLERRASQSTLQLQLAPSIEHQSAAMLSILERYKWHQ----------FSV------- 257
             |:..|        :.....:|:.|:::   .|:||:|..|||.:          |||
  Rat   121 PSFPTD--------ADVQFVIQMRPALK---GAILSLLGYYKWEKFVYLYDTERGFSVLQAIMEA 174

  Fly   258 -------VTSQIAGHDDFVQAVRERVAEMQEHFKFTILNSIVVTRTSDLMELVNSEARVMLL--- 312
                   ||::..|:...||..|..:.||....:...|....|.|.:.::|      :|::|
  Rat   175 AVQNNWQVTARSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILE------QVVILGKH 233

  Fly   313 -----YATQTEAITILRAAEEM----KLTG---------------ENYVWVVSQSVIEKKDAHSQ 353
                 |.......|.:.....|    .:||               :.:|.:..:...|.|:|..:
  Rat   234 SRGYHYMLANLGFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKNAPLK 298

  Fly   354 FPVGMLGVHFDTSSAALMNEISNAIKIYSYGVEAYLTDPANRDRRLTTQSLSCEDEGRG------ 412
            :            ::||.::   ||.:.:   ||:        |.|..|.:.....|..
  Rat   299 Y------------TSALTHD---AILVIA---EAF--------RYLRRQRVDVSRRGSAGDCLAN 337

  Fly   413 ---RWDNGEIFFKYLRNVSIEGDLNKPNIEFTADGDLRSAELKIMNLRPSANNKNLVWEEIGVWK 474
               .|..|....:.|:.|.::|...  ||:|...|...:..:.:..::.|.:.|      .|.|.
  Rat   338 PAVPWSQGIDIERALKMVQVQGMTG--NIQFDTYGRRTNYTIDVYEMKVSGSRK------AGYWN 394

  Fly   475 SWETQKLDIRDIAWPGNSHAPPQGVPEKFHLKITFLEEAPYINLSPADPVSGKCLMDRGVLCRVA 539
            .:|      |.:.:.....:......|...:.:|.:.|:||:                    ...
  Rat   395 EYE------RFVPFSDQQISNDSSSSENRTIVVTTILESPYV--------------------MYK 433

  Fly   540 ADHEMAADIDVGQAHRNESFYQCCSGFCIDLLEKFAEELGFTYELVRVEDGKWGTL--ENGKWNG 602
            .:||        |...||.:    .|:|:||..:.|:.:...|:|..|.|||:|..  |...|||
  Rat   434 KNHE--------QLEGNERY----EGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIWNG 486

  Fly   603 LIADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGIAIVVAK----RTGIISPTAFLEPFDTA 663
            ::.:||..:.|:.:..|.|...||.|:|||:|||..||:|::.|    :.|:.|   ||:|....
  Rat   487 MVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFS---FLDPLAYE 548

  Fly   664 SWMLVGIVAIQAATFMIFLFEWLSPSGYDMKLYLQNTNV----------TPYRFSLFRTYWLVWA 718
            .||.: :.|....:.::||....||  |:.  :|::.|.          .|..|.:|.:.|....
  Rat   549 IWMCI-VFAYIGVSVVLFLVSRFSP--YEW--HLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLG 608

  Fly   719 VLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAAFMITREEFHEFSGLNDSRLVHP-- 781
            ...|....: |||..:.|.:..||..|.::.::.||||||||            |...|:|.|
  Rat   609 AFMQQGCDI-SPRSLSGRIVGGVWWFFTLIIISSYTANLAAF------------LTVERMVSPIE 660

  Fly   782 ----FSHKPSFKFGTIPYSHTDSTIHK----YFNVMHNYMRQ-----YNKTSVADGVAAV--LNG 831
                .:.:....:||:....|.....:    .:..|.:||:.     :.||: |||||.|  ..|
  Rat   661 SAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTT-ADGVARVRKSKG 724

  Fly   832 NLDSFIYDGTVLDYLVAQDEDCRLMTVGSWYAMTGYGLAFSRNSKYVQMFNKRLLEFRANGDLER 896
            .. :|:.:.|:.:| :.|.:.|..|.||......|||:|..:.|......|..:|:....|.|::
  Rat   725 KF-AFLLESTMNEY-IEQRKPCDTMKVGGNLDSKGYGVATPKGSALGTPVNLAVLKLSEQGILDK 787

  Fly   897 LRRYWM--TGTCRPGKQEHKSSD---PLALEQFLSAFLLLMAGILLAALLLLLEHVY 948
            |:..|.  .|.|  |.::..|.|   .|:|......|.:|:.|:.||.::.|:|..|
  Rat   788 LKNKWWYDKGEC--GAKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCY 842

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..485	CDD:380601	76/399 (19%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	118/440 (27%)
Gria3	NP_116785.2	PBP1_iGluR_AMPA_GluR3	29..403	CDD:380610	77/403 (19%)
		PBP2_iGluR_AMPA	416..799	CDD:270433	117/438 (27%)