Protein Alignment Nmdar2 and Gria2

DIOPT Version :10

• Sequence 1: NP_001014714.1
• Gene: Nmdar2 / 31107
• FlyBaseID: FBgn0053513
• Length: 1083
• Species: Drosophila melanogaster
• Sequence 2: NP_058957.1
• Gene: Gria2 / 29627
• RGDID: 61862
• Length: 883
• Species: Rattus norvegicus
• Alignment Length: 985
• Identity: 232/985 - (23%)
• Similarity: 388/985 - (39%)
• Gaps: 250/985 - (25%)

  Fly    60 ISLLLLTVLTLLILDTRSCQGLRLTNGGGSLSKGAAANKEQLNIGLIAPHTNFGKREYLRSINNA 124
            ||:||..||..||... |...:::   ||...:||........:|::    .|...|:
  Rat     7 ISVLLSPVLWGLIFGV-SSNSIQI---GGLFPRGADQEYSAFRVGMV----QFSTSEF------- 56

  Fly   125 VTGLTKTRGAKLTFLKDYSFEQKNIHFDMMSLTPSPTAILSTLCKEFLRVNVSAILYMMNNEQFG 189
                      :||           .|.|.:.:..| .|:.:..|.:|.| .|.||        ||
  Rat    57 ----------RLT-----------PHIDNLEVANS-FAVTNAFCSQFSR-GVYAI--------FG 90

  Fly   190 -HSTASAQYFLQLAGYLGIPVISWNADNSGLERRASQSTLQLQLAPSIEHQSAAMLSILERYKWH 253
             :...|........|.|.:..|:.:....|..      ...:|:.|.::   .|:||::|.|:|.
  Rat    91 FYDKKSVNTITSFCGTLHVSFITPSFPTDGTH------PFVIQMRPDLK---GALLSLIEYYQWD 146

  Fly   254 QFSVVTSQIAGHDDFVQAVRERVAEMQEHFKFTILNSIVV-------TRTSDLMEL-VNSEARVM 310
            :|:.:.....|... :|||.:..||  :.::.|.:|...:       |..|...:| :..|.||:
  Rat   147 KFAYLYDSDRGLST-LQAVLDSAAE--KKWQVTAINVGNINNDKKDETYRSLFQDLELKKERRVI 208

  Fly   311 L------LYATQTEAITILRAAEEMKLTGENYV-------------------------------- 337
            |      :.....:.|||   .:.:|  |.:|:
  Rat   209 LDCERDKVNDIVDQVITI---GKHVK--GYHYIIANLGFTDGDLLKIQFGGANVSGFQIVDYDDS 268

  Fly   338 ----WVVSQSVIEKKDAHSQFPVGMLGVHFDTSSAALMNEIS-NAIKIYSYGVEAYLTDPANRDR 397
                ::...|.:|:|    ::|    |.|  |::....:.:: :|:::.:   ||:        |
  Rat   269 LVSKFIERWSTLEEK----EYP----GAH--TATIKYTSALTYDAVQVMT---EAF--------R 312

  Fly   398 RLTTQSLSCEDEGRG---------RWDNGEIFFKYLRNVSIEGDLNKPNIEFTADGDLRSAELKI 453
            .|..|.:.....|..         .|..|....:.|:.|.:||  ...||:|..:|...:..:.|
  Rat   313 NLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEG--LSGNIKFDQNGKRINYTINI 375

  Fly   454 MNLRPSANNKNLVWEEIGVWKSWETQKLDIRDIAWP-GNSHAPPQGVPEKFHLKITFLEEAPYIN 517
            |.|:.:...|      ||.|.  |..|:.:.....| ||.   ..|:..| .:.:|.:.|:||:.
  Rat   376 MELKTNGPRK------IGYWS--EVDKMVVTLTELPSGND---TSGLENK-TVVVTTILESPYVM 428

  Fly   518 LSPADPVSGKCLMDRGVLCRVAADHEMAADIDVGQAHRNESFYQCCSGFCIDLLEKFAEELGFTY 582
            :.                    .:|||        ...||.:    .|:|:||..:.|:..||.|
  Rat   429 MK--------------------KNHEM--------LEGNERY----EGYCVDLAAEIAKHCGFKY 461

  Fly   583 ELVRVEDGKWGT--LENGKWNGLIADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGIAIVVA 645
            :|..|.|||:|.  .:...|||::.:||..|.|:.:..|.|...||.|:|||:|||..||:|::.
  Rat   462 KLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIK 526

  Fly   646 K----RTGIISPTAFLEPFDTASWMLVGIVAIQAATFMIFLFEWLSPSGYDMKLY--------LQ 698
            |    :.|:.|   ||:|.....||.: :.|....:.::||....||..:..:.:        .:
  Rat   527 KPQKSKPGVFS---FLDPLAYEIWMCI-VFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSE 587

  Fly   699 NTNVTPYRFSLFRTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAAFMIT 763
            :||    .|.:|.:.|.......:....: |||..:.|.:..||..|.::.::.||||||||
  Rat   588 STN----EFGIFNSLWFSLGAFMRQGCDI-SPRSLSGRIVGGVWWFFTLIIISSYTANLAAF--- 644

  Fly   764 REEFHEFSGLNDSRLVHP------FSHKPSFKFGTIPYSHTDSTIHK----YFNVMHNYMRQYNK 818
                     |...|:|.|      .|.:....:||:....|.....:    .|:.|..|||....
  Rat   645 ---------LTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEP 700

  Fly   819 T----SVADGVAAVLNG-NLDSFIYDGTVLDYLVAQDEDCRLMTVGSWYAMTGYGLAFSRNSKYV 878
            :    :.|:|||.|... ...:::.:.|:.:| :.|.:.|..|.||......|||:|..:.|...
  Rat   701 SVFVRTTAEGVARVRKSKGKYAYLLESTMNEY-IEQRKPCDTMKVGGNLDSKGYGIATPKGSSLG 764

  Fly   879 QMFNKRLLEFRANGDLERLRRYWM--TGTC---RPGKQEHKSSDPLALEQFLSAFLLLMAGILLA 938
            ...|..:|:....|.|::|:..|.  .|.|   ..|.:|..|:  |:|......|.:|:.|:.||
  Rat   765 TPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSKEKTSA--LSLSNVAGVFYILVGGLGLA 827

  Fly   939 ALLLLLEHVY 948
            .|:.|:|..|
  Rat   828 MLVALIEFCY 837

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..485	CDD:380601	85/446 (19%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	116/439 (26%)
Gria2	NP_058957.1	PBP1_iGluR_AMPA_GluR2	28..398	CDD:380612	89/462 (19%)
		PBP2_iGluR_AMPA	413..794	CDD:270433	115/435 (26%)
		Required for interaction with IQSEC1. /evidence=ECO:0000269|PubMed:20547133	867..877