Protein Alignment Nmdar2 and Grik1

DIOPT Version :10

• Sequence 1: NP_001014714.1
• Gene: Nmdar2 / 31107
• FlyBaseID: FBgn0053513
• Length: 1083
• Species: Drosophila melanogaster
• Sequence 2: NP_001104587.1
• Gene: Grik1 / 29559
• RGDID: 2732
• Length: 949
• Species: Rattus norvegicus
• Alignment Length: 1037
• Identity: 236/1037 - (22%)
• Similarity: 407/1037 - (39%)
• Gaps: 246/1037 - (23%)

  Fly    66 TVLTLL-----ILDTRSCQGLRLTNGGGSLSKGAAANKEQLNIGLIAPHTNFGKREYLRSINNAV 125
            |..|||     ||...|.|.||:   ||...   ....|.:|:..:|             ...||
  Rat    17 TSWTLLYFLCYILPQTSPQVLRI---GGIFE---TVENEPVNVEELA-------------FKFAV 62

  Fly   126 TGLTKTRGAKLTFLKDYSFEQKNIHFDMMSLTPSPTAILSTLCKEFLRVNVSAILYMMNNEQFGH 190
            |.:.:.|.........|..::.|: ||  |...|..|     |.: |.:.|:|:        ||.
  Rat    63 TSINRNRTLMPNTTLTYDIQRINL-FD--SFEASRRA-----CDQ-LALGVAAL--------FGP 110

  Fly   191 STASAQYFLQ-LAGYLGIPVISWNADNSGLERRASQSTLQLQLAPSIEHQSAAMLSILERYKWHQ 254
            |.:|:...:| :...|.:|.|.....:..::   |:....:.|.|.....|.|:|.::..|.|..
  Rat   111 SHSSSVSAVQSICNALEVPHIQTRWKHPSVD---SRDLFYINLYPDYAAISRAVLDLVLYYNWKT 172

  Fly   255 FSVVTSQIAGHDDFVQAVR-ERVAEMQEHFKFTILNSIVVTRTSD----LMELVNSEARVMLLYA 314
            .:||      ::|....:| :.:.:....:...|....:.....|    |.|:..|:...::...
  Rat   173 VTVV------YEDSTGLIRLQELIKAPSRYNIKIKIRQLPPANKDAKPLLKEMKKSKEFYVIFDC 231

  Fly   315 TQTEAITILRAAEEMKLTGENYVWVVS--------------------------------QSVIEK 347
            :...|..||:....|.:..|.|.:..:                                .|:|||
  Rat   232 SHETAAEILKQILFMGMMTEYYHYFFTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEK 296

  Fly   348 KDAHS-QFPV--------GMLGVHFDTSSAALMNEISNAIKIYSYGVEAYLTDPANRDRRLTTQS 403
            ..... |.|.        ||:     |:.||||.:....:.|.|:           |..:||..|
  Rat   297 WSMERLQAPPRPETGLLDGMM-----TTEAALMYDAVYMVAIASH-----------RASQLTVSS 345

  Fly   404 LSCEDEGRGR-WDNGEIFFKYLRNVSIEGDLNKPNIEFTADGDLRSAELKIMNLRPSAN------ 461
            |.|.   |.: |..|..|...::....:|...:.....| ||..:..:|.|::|:....
  Rat   346 LQCH---RHKPWRLGPRFMNLIKEARWDGLTGRITFNKT-DGLRKDFDLDIISLKEEGTEKASGE 406

  Fly   462 -NKNL--VWEEIGVWKSWETQKLDIRDIAWPGN---SHAPPQGVPEKFHLKITFLEEAPYINLSP 520
             :|:|  ||::||:|.|  ...|::.|    ||   |:.....:..:..:..|.||| ||:....
  Rat   407 VSKHLYKVWKKIGIWNS--NSGLNMTD----GNRDRSNNITDSLANRTLIVTTILEE-PYVMYRK 464

  Fly   521 AD-PVSGKCLMDRGVLCRVAADHEMAADIDVGQAHRNESFYQCCSGFCIDLLEKFAEELGFTYEL 584
            :| |:.|                             |:.|    .|:|:|||::.:..|||.|::
  Rat   465 SDKPLYG-----------------------------NDRF----EGYCLDLLKELSNILGFLYDV 496

  Fly   585 VRVEDGKWGTL-ENGKWNGLIADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGIAIVVAKRT 648
            ..|.|||:|.. :.|:|||::.:|::.:.|:.:..|.|...||.|:|||:|||..||:|:..|..
  Rat   497 KLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPN 561

  Fly   649 GIISP--TAFLEPFDTASWM--LVGIVAIQAATFMIFLF---EWLSPSGYDMKLYLQNTNVTPYR 706
            | .:|  .:||.|.....||  |:..:.:....|:|..|   ||.:|...:     .:::|....
  Rat   562 G-TNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCN-----PDSDVVENN 620

  Fly   707 FSLFRTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAAFM---------- 761
            |:|..::|.....|.|....: .|:..::|.:..:|..|.::.::.||||||||:
  Rat   621 FTLLNSFWFGVGALMQQGSEL-MPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPID 684

  Fly   762 ----ITREEFHEFSGLNDSRLVHPFSHKPSFKFGTIPYSHTDSTIHKYFNVMHNYMRQYNKTSVA 822
                :.::...|:..:.|.      |....||...|      ||..|.:..|.:..:.....:..
  Rat   685 SADDLAKQTKIEYGAVRDG------STMTFFKKSKI------STYEKMWAFMSSRQQSALVKNSD 737

  Fly   823 DGVAAVLNGNLDSFIYDGTVLDYLVAQDEDCRLMTVGSWYAMTGYGLAFSRNSKYVQMFNKRLLE 887
            :|:..||..:. :.:.:.|.::|:.  ..:|.|..:|......|||:.....|.|.......:|:
  Rat   738 EGIQRVLTTDY-ALLMESTSIEYVT--QRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQ 799

  Fly   888 FRANGDLERLRRYWMTGTCRPGKQEHKSSDPLALEQFLSAFLLLMAGILLAALLLLLEHVYFK-- 950
            .:..|.|..::..|..|...| :::.|.:..|.:|.....|::|.||::|:..:.:.|.:|..
  Rat   800 LQEEGKLHMMKEKWWRGNGCP-EEDSKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFLYKSRK 863

  Fly   951 ---------------YIRKRL----AKKDGGHCCALISLSMGKSLTFRGAVFEATEILKKHR 993
                           |.|.::    :||:        ||.:.|.|:| .|:.|...|..|::
  Rat   864 NNDVEQKGKSSRLRFYFRNKVRFHGSKKE--------SLGVEKCLSF-NAIMEELGISLKNQ 916

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..485	CDD:380601	90/442 (20%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	106/428 (25%)
Grik1	NP_001104587.1	PBP1_iGluR_Kainate	38..431	CDD:380605	93/459 (20%)
		Periplasmic_Binding_Protein_Type_2	446..815	CDD:473866	105/424 (25%)