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Protein Alignment Nmdar2 and GRIN2D

DIOPT Version :9

Sequence 1:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster
Sequence 2:	NP_000827.2	Gene:	GRIN2D / 2906	HGNCID:	4588	Length:	1336	Species:	Homo sapiens

Alignment Length:	965	Identity:	288/965 - (29%)
Similarity:	457/965 - (47%)	Gaps:	129/965 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 PSGPISLLLLTVLTLLILDTRSCQGLRLTNGGGSLSKGAAANKEQLNIGLIAPHTNFGKREYLRS 120
            |.||..:|||..|...........|    .||.....|.......||:.|:     |....|...
Human    10 PRGPAKMLLLLALACASPFPEEAPG----PGGAGGPGGGLGGARPLNVALV-----FSGPAYAAE 65

  Fly   121 ---INNAVTGLTKTRGAKLTFLKDYSFEQKNIHFDMMSLTP--------SPTAILSTLCKEFLRV 174
               :..||....::.|                    :.:.|        .|.:::..||.....:
Human    66 AARLGPAVAAAVRSPG--------------------LDVRPVALVLNGSDPRSLVLQLCDLLSGL 110

  Fly   175 NVSAILYMMNNEQFGHSTASAQYFLQLAGYLGIPVISWNADNSGLERRASQSTLQLQLAPSIEHQ 239
            .|..:::    |....:.|.|.....|:....:|:::.:...:.:.....:.:..|||..|.|.|
Human   111 RVHGVVF----EDDSRAPAVAPILDFLSAQTSLPIVAVHGGAALVLTPKEKGSTFLQLGSSTEQQ 171

  Fly   240 SAAMLSILERYKWHQFSVVTSQIAGHDDF---VQAVRERVAEMQEHFKFTILN----SIVVTRTS 297
            ...:..:||.|.|..|..||::..||..|   ::.:.:......||.....|:    ..|::
Human   172 LQVIFEVLEEYDWTSFVAVTTRAPGHRAFLSYIEVLTDGSLVGWEHRGALTLDPGAGEAVLS--- 233

  Fly   298 DLMELVNSEARVMLLYATQTEAITILRAAEEMKLTGENYVWVVSQSVIEKKDAH----------- 351
              .:|.:..|::.||:..:.||..:.|||||..|||..|||.:....:......
Human   234 --AQLRSVSAQIRLLFCAREEAEPVFRAAEEAGLTGSGYVWFMVGPQLAGGGGSGAPGEPPLLPG 296

  Fly   352 -SQFPVGMLGVHFDTSSAALMNEISNAIKIYSYGVEAYLTD----PANRDRRLTTQSLSCEDEGR 411
             :..|.|:..|........|...::..:.:.:.|.:|.|.|    |          .|..:...:
Human   297 GAPLPAGLFAVRSAGWRDDLARRVAAGVAVVARGAQALLRDYGFLP----------ELGHDCRAQ 351

  Fly   412 GRWDNGEIFFKYLRNVSIEGDLNKPNIEFTADGDLRSAELKIMNLRPSANNKNLVWEEIGVWKSW 476
            .|...||...:|..|::.:   |: :..|..||.|.:..|.:::|     .::..||.:|   ||
Human   352 NRTHRGESLHRYFMNITWD---NR-DYSFNEDGFLVNPSLVVISL-----TRDRTWEVVG---SW 404

  Fly   477 ETQKLDIRDIAWP--GNSHAPPQGVPEKFHLKITFLEEAPYINLSPADPVSGKCLMDRGVLCRVA 539
            |.|.|.::...|.  |....|   |.:..||.:..|||.|::.:.||||:||.|:.| .|.||..
Human   405 EQQTLRLKYPLWSRYGRFLQP---VDDTQHLTVATLEERPFVIVEPADPISGTCIRD-SVPCRSQ 465

  Fly   540 ADHEMAADIDVGQAHRNESFYQCCSGFCIDLLEKFAEELGFTYELVRVEDGKWGTLENGKWNGLI 604
            .:...:...|   |.|.|.  :||.|||||:|::.|..:||:|:|..|.:||.|...:|.|||:|
Human   466 LNRTHSPPPD---APRPEK--RCCKGFCIDILKRLAHTIGFSYDLYLVTNGKHGKKIDGVWNGMI 525

  Fly   605 ADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGIAIVVAKRTGIISPTAFLEPFDTASWMLVG 669
            .::..::.||.:.||.||.||..:||||.||:||||:::||:..|.:||:|||||:..|.|:::.
Human   526 GEVFYQRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLEPYSPAVWVMMF 590

  Fly   670 IVAIQAATFMIFLFEWLSPSGYDMKLYLQNTNVTP--YRFSLFRTYWLVWAVLFQAAVHVDSPRG 732
            ::.:......:|:||:|||.||:..|   .|...|  ..|::.::.||:||::|..:|.|::|||
Human   591 VMCLTVVAVTVFIFEYLSPVGYNRSL---ATGKRPGGSTFTIGKSIWLLWALVFNNSVPVENPRG 652

  Fly   733 FTSRFMTNVWALFAVVFLAIYTANLAAFMITREEFHEFSGLNDSRLVHPFSHKPSFKFGTIPYSH 797
            .||:.|..|||.|||:|||.||||||||||..|.....|||:|.:...|....|..||||:|...
Human   653 TTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGTVPNGS 717

  Fly   798 TDSTIHKYFNVMHNYMRQYNKTSVADGVAAVLNGNLDSFIYDGTVLDYLVAQDEDCRLMTVGSW- 861
            |:..|...:..||:||.:||:..|.:.:..:..|.||:||||..||:|:..:||.|:|:|:||.
Human   718 TEKNIRSNYPDMHSYMVRYNQPRVEEALTQLKAGKLDAFIYDAAVLNYMARKDEGCKLVTIGSGK 782

  Fly   862 -YAMTGYGLAFSRNSKYVQMFNKRLLEFRANGDLERLRRYWMTGTCRPGKQEHKSSDPLALEQFL 925
             :|.||||:|..:.|::.:..:..||:|..:.::|.|.|.|::|.|...|.|..|| .|.::...
Human   783 VFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWLSGICHNDKIEVMSS-KLDIDNMA 846

  Fly   926 SAFLLLMAGILLAALLLLLEHVYFKYIRKRLAKKDGGHCCA-------LISLSMG 973
            ..|.:|:..:.|:.|:...||:.:..:|         ||..       |::.|.|
Human   847 GVFYMLLVAMGLSLLVFAWEHLVYWRLR---------HCLGPTHRMDFLLAFSRG 892

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.