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Protein Alignment Nmdar2 and GRIN2B

DIOPT Version :9

Sequence 1:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster
Sequence 2:	NP_000825.2	Gene:	GRIN2B / 2904	HGNCID:	4586	Length:	1484	Species:	Homo sapiens

Alignment Length:	1034	Identity:	304/1034 - (29%)
Similarity:	490/1034 - (47%)	Gaps:	183/1034 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 LKDYSFEQKNIHFDMMSLTP----------SPTAILSTLCKEFLRVNVSAILYMMNNEQFGHSTA 193
            :|| :.|:.:.|.  :|:.|          .|.:|::.:|.......:..:::..:.:|    .|
Human    50 IKD-AHEKDDFHH--LSVVPRVELVAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQ----EA 107

  Fly   194 SAQYFLQLAGYLGIPVISWNADNSGLERRASQSTLQLQLAPSIEHQSAAMLSILERYKWHQFSVV 258
            .||....::.....|::..:..:|.:.....:|::..|..||||.|::.||:|:|.|.|:.||:|
Human   108 IAQILDFISAQTLTPILGIHGGSSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIV 172

  Fly   259 TSQIAGHDDFVQAVRERVAEMQEHFKFTILNSIVVTRTSDLM---------------ELVNSEAR 308
            |:...|:.|||..:|.           ||.||.|.....:::               :|...::.
Human   173 TTYFPGYQDFVNKIRS-----------TIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSP 226

  Fly   309 VMLLYATQTEAITILRAAEEMKLTGENYVWVVSQSVIEKKD-AHSQFPVGMLGVHFDTSSAALMN 372
            ::|||.|:.||..|...|..:.|||..|.|:|...|....| ..::||.|::.|.:|.....|..
Human   227 IILLYCTKEEATYIFEVANSVGLTGYGYTWIVPSLVAGDTDTVPAEFPTGLISVSYDEWDYGLPA 291

  Fly   373 EISNAIKIYSYGV------EAYLTDPANRDRRLTTQSLSCEDEGRGRWDNGEIFFKYLRNVSIEG 431
            .:.:.|.|.:...      .:::.:|.:          ||.:....|.....:..:||.||:.||
Human   292 RVRDGIAIITTAASDMLSEHSFIPEPKS----------SCYNTHEKRIYQSNMLNRYLINVTFEG 346

  Fly   432 DLNKPNIEFTADGDLRSAELKIMNLRPSANNKNLVWEEIGVWKSWETQKLDIRDIAWPGNSHAPP 496
                .|:.|:.||.....:|.|:.|     ||...||.:|.||.   :.|.::...||  ...|.
Human   347 ----RNLSFSEDGYQMHPKLVIILL-----NKERKWERVGKWKD---KSLQMKYYVWP--RMCPE 397

  Fly   497 QGVPEKFHLKITFLEEAPYINLSPADPVSGKCLMDRGVLCRVAADHEMAADIDVGQAHRNESFYQ 561
            ....|..||.|..|||||::.:...||:||.| |...|.|:.....|...|.:.|...:
Human   398 TEEQEDDHLSIVTLEEAPFVIVESVDPLSGTC-MRNTVPCQKRIVTENKTDEEPGYIKK------ 455

  Fly   562 CCSGFCIDLLEKFAEELGFTYELVRVEDGKWGTLENGKWNGLIADLVNRKTDMVLTSLMINTERE 626
            ||.|||||:|:|.::.:.|||:|..|.:||.|...||.|||:|.::|.::..|.:.||.||.||.
Human   456 CCKGFCIDILKKISKSVKFTYDLYLVTNGKHGKKINGTWNGMIGEVVMKRAYMAVGSLTINEERS 520

  Fly   627 AVVDFSEPFMETGIAIVVAKRTGIISPTAFLEPFDTASWMLVGIVAIQAATFMIFLFEWLSPSGY 691
            .|||||.||:||||:::|::..|.:||:||||||....|:::.::.:..:...:|:||:.||.||
Human   521 EVVDFSVPFIETGISVMVSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGY 585

  Fly   692 DMKLYLQNTNVTPYRFSLFRTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTAN 756
            :..|........| .|::.:..||:|.::|..:|.|.:|:|.||:.|.:|||.|||:|||.||||
Human   586 NRCLADGREPGGP-SFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTAN 649

  Fly   757 LAAFMITREEFHEFSGLNDSRLVHPFSHKPSFKFGTIPYSHTDSTIHKYFNVMHNYMRQYNKTSV 821
            ||||||..|...:.|||:|.:...|....|.|:|||:|...|:..|...:..||.||.::|:..|
Human   650 LAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNNYAEMHAYMGKFNQRGV 714

  Fly   822 ADGVAAVLNGNLDSFIYDGTVLDYLVAQDEDCRLMTVGSW--YAMTGYGLAFSRNSKYVQMFNKR 884
            .|.:.::..|.||:||||..||:|:..:||.|:|:|:||.  :|.||||:|..::|.:.:..:..
Human   715 DDALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLA 779

  Fly   885 LLEFRANGDLERLRRYWMTGTCRPGKQEHKSSDPLALEQFLSAFLLLMAGILLAALLLLLEHVYF 949
            :|:...:|::|.|...|:||.|...|.|..||. |.::.....|.:|.|.:.|:.:..:.||:::
Human   780 ILQLFGDGEMEELEALWLTGICHNEKNEVMSSQ-LDIDNMAGVFYMLGAAMALSLITFICEHLFY 843

  Fly   950 KYIRKRLAKKDGGHC----CA-----LISLSMGKSLTFRGAVFEA----------------TEIL 989
            ...|         ||    |:     :.|:|.|......|...|.                :.||
Human   844 WQFR---------HCFMGVCSGKPGMVFSISRGIYSCIHGVAIEERQSVMNSPTATMNNTHSNIL 899

  Fly   990 K-----------------------------------KHR-------C---NDPICDTHLWKVKHE 1009
            :                                   :||       |   |:|.|:.:|:.
Human   900 RLLRTAKNMANLSGVNGSPQSALDFIRRESSVYDISEHRRSFTHSDCKSYNNPPCEENLFS---- 960

  Fly  1010 LDMSRLRVRQLEKVMDKHGIKAPQLRLASSSDLLNHHHLKERPPLLGNLSLAASAQDLY 1068
             |.    :.::|:...       .|:|..|:...:|:|...||..:|:   |:|...||
Human   961 -DY----ISEVERTFG-------NLQLKDSNVYQDHYHHHHRPHSIGS---ASSIDGLY 1004

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.