Protein Alignment Nmdar2 and GRIN2B

DIOPT Version :10

• Sequence 1: NP_001014714.1
• Gene: Nmdar2 / 31107
• FlyBaseID: FBgn0053513
• Length: 1083
• Species: Drosophila melanogaster
• Sequence 2: NP_000825.2
• Gene: GRIN2B / 2904
• HGNCID: 4586
• Length: 1484
• Species: Homo sapiens
• Alignment Length: 1034
• Identity: 304/1034 - (29%)
• Similarity: 490/1034 - (47%)
• Gaps: 183/1034 - (17%)

  Fly   139 LKDYSFEQKNIHFDMMSLTP----------SPTAILSTLCKEFLRVNVSAILYMMNNEQFGHSTA 193
            :|| :.|:.:.|.  :|:.|          .|.:|::.:|.......:..:::..:.:|    .|
Human    50 IKD-AHEKDDFHH--LSVVPRVELVAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQ----EA 107

  Fly   194 SAQYFLQLAGYLGIPVISWNADNSGLERRASQSTLQLQLAPSIEHQSAAMLSILERYKWHQFSVV 258
            .||....::.....|::..:..:|.:.....:|::..|..||||.|::.||:|:|.|.|:.||:|
Human   108 IAQILDFISAQTLTPILGIHGGSSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIV 172

  Fly   259 TSQIAGHDDFVQAVRERVAEMQEHFKFTILNSIVVTRTSDLM---------------ELVNSEAR 308
            |:...|:.|||..:|.           ||.||.|.....:::               :|...::.
Human   173 TTYFPGYQDFVNKIRS-----------TIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSP 226

  Fly   309 VMLLYATQTEAITILRAAEEMKLTGENYVWVVSQSVIEKKD-AHSQFPVGMLGVHFDTSSAALMN 372
            ::|||.|:.||..|...|..:.|||..|.|:|...|....| ..::||.|::.|.:|.....|..
Human   227 IILLYCTKEEATYIFEVANSVGLTGYGYTWIVPSLVAGDTDTVPAEFPTGLISVSYDEWDYGLPA 291

  Fly   373 EISNAIKIYSYGV------EAYLTDPANRDRRLTTQSLSCEDEGRGRWDNGEIFFKYLRNVSIEG 431
            .:.:.|.|.:...      .:::.:|.:          ||.:....|.....:..:||.||:.||
Human   292 RVRDGIAIITTAASDMLSEHSFIPEPKS----------SCYNTHEKRIYQSNMLNRYLINVTFEG 346

  Fly   432 DLNKPNIEFTADGDLRSAELKIMNLRPSANNKNLVWEEIGVWKSWETQKLDIRDIAWPGNSHAPP 496
                .|:.|:.||.....:|.|:.|     ||...||.:|.||.   :.|.::...||  ...|.
Human   347 ----RNLSFSEDGYQMHPKLVIILL-----NKERKWERVGKWKD---KSLQMKYYVWP--RMCPE 397

  Fly   497 QGVPEKFHLKITFLEEAPYINLSPADPVSGKCLMDRGVLCRVAADHEMAADIDVGQAHRNESFYQ 561
            ....|..||.|..|||||::.:...||:||.| |...|.|:.....|...|.:.|...:
Human   398 TEEQEDDHLSIVTLEEAPFVIVESVDPLSGTC-MRNTVPCQKRIVTENKTDEEPGYIKK------ 455

  Fly   562 CCSGFCIDLLEKFAEELGFTYELVRVEDGKWGTLENGKWNGLIADLVNRKTDMVLTSLMINTERE 626
            ||.|||||:|:|.::.:.|||:|..|.:||.|...||.|||:|.::|.::..|.:.||.||.||.
Human   456 CCKGFCIDILKKISKSVKFTYDLYLVTNGKHGKKINGTWNGMIGEVVMKRAYMAVGSLTINEERS 520

  Fly   627 AVVDFSEPFMETGIAIVVAKRTGIISPTAFLEPFDTASWMLVGIVAIQAATFMIFLFEWLSPSGY 691
            .|||||.||:||||:::|::..|.:||:||||||....|:::.::.:..:...:|:||:.||.||
Human   521 EVVDFSVPFIETGISVMVSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGY 585

  Fly   692 DMKLYLQNTNVTPYRFSLFRTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTAN 756
            :..|........| .|::.:..||:|.::|..:|.|.:|:|.||:.|.:|||.|||:|||.||||
Human   586 NRCLADGREPGGP-SFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTAN 649

  Fly   757 LAAFMITREEFHEFSGLNDSRLVHPFSHKPSFKFGTIPYSHTDSTIHKYFNVMHNYMRQYNKTSV 821
            ||||||..|...:.|||:|.:...|....|.|:|||:|...|:..|...:..||.||.::|:..|
Human   650 LAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNNYAEMHAYMGKFNQRGV 714

  Fly   822 ADGVAAVLNGNLDSFIYDGTVLDYLVAQDEDCRLMTVGSW--YAMTGYGLAFSRNSKYVQMFNKR 884
            .|.:.::..|.||:||||..||:|:..:||.|:|:|:||.  :|.||||:|..::|.:.:..:..
Human   715 DDALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLA 779

  Fly   885 LLEFRANGDLERLRRYWMTGTCRPGKQEHKSSDPLALEQFLSAFLLLMAGILLAALLLLLEHVYF 949
            :|:...:|::|.|...|:||.|...|.|..||. |.::.....|.:|.|.:.|:.:..:.||:::
Human   780 ILQLFGDGEMEELEALWLTGICHNEKNEVMSSQ-LDIDNMAGVFYMLGAAMALSLITFICEHLFY 843

  Fly   950 KYIRKRLAKKDGGHC----CA-----LISLSMGKSLTFRGAVFEA----------------TEIL 989
            ...|         ||    |:     :.|:|.|......|...|.                :.||
Human   844 WQFR---------HCFMGVCSGKPGMVFSISRGIYSCIHGVAIEERQSVMNSPTATMNNTHSNIL 899

  Fly   990 K-----------------------------------KHR-------C---NDPICDTHLWKVKHE 1009
            :                                   :||       |   |:|.|:.:|:.
Human   900 RLLRTAKNMANLSGVNGSPQSALDFIRRESSVYDISEHRRSFTHSDCKSYNNPPCEENLFS---- 960

  Fly  1010 LDMSRLRVRQLEKVMDKHGIKAPQLRLASSSDLLNHHHLKERPPLLGNLSLAASAQDLY 1068
             |.    :.::|:...       .|:|..|:...:|:|...||..:|:   |:|...||
Human   961 -DY----ISEVERTFG-------NLQLKDSNVYQDHYHHHHRPHSIGS---ASSIDGLY 1004

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..485	CDD:380601	92/377 (24%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	165/407 (41%)
GRIN2B	NP_000825.2	PBP1_iGluR_NMDA_NR2	33..388	CDD:380601	92/377 (24%)
		PBP2_iGluR_NMDA_Nr2	403..803	CDD:270436	165/407 (41%)
		Pore-forming. /evidence=ECO:0000250|UniProtKB:A7XY94	604..623		6/18 (33%)
		NMDAR2_C	840..1484	CDD:463148	33/193 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1074..1097
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1161..1194
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1271..1301
		Interaction with DAPK1. /evidence=ECO:0000250|UniProtKB:Q01097	1292..1304
		PDZ-binding. /evidence=ECO:0000250	1482..1484