Protein Alignment Nmdar2 and GRIN2A

DIOPT Version :10

• Sequence 1: NP_001014714.1
• Gene: Nmdar2 / 31107
• FlyBaseID: FBgn0053513
• Length: 1083
• Species: Drosophila melanogaster
• Sequence 2: XP_016878661.1
• Gene: GRIN2A / 2903
• HGNCID: 4585
• Length: 1516
• Species: Homo sapiens
• Alignment Length: 901
• Identity: 276/901 - (30%)
• Similarity: 463/901 - (51%)
• Gaps: 78/901 - (8%)

  Fly    69 TLLILDTRSCQGLRLTNGGGSLSKGAAANKEQLNIGLIAPHTNFGKREYLRSINNAVTGLTKTRG 133
            |||:|..      .|...|.:.|..|......|||.::..|::......||::    .|..:..|
Human    60 TLLVLPA------LLVWRGPAPSAAAEKGPPALNIAVMLGHSHDVTERELRTL----WGPEQAAG 114

  Fly   134 AKLTFLKDYSFEQKNIHFDMMSLTPSPTAILSTLCKEFLRVNVSAILYMMNNEQFGHSTASAQYF 198
            ..|         ..|:...:|:.| .|.::::.:|.......:..:::..:.:|    .|.||..
Human   115 LPL---------DVNVVALLMNRT-DPKSLITHVCDLMSGARIHGLVFGDDTDQ----EAVAQML 165

  Fly   199 LQLAGYLGIPVISWNADNSGLERRASQSTLQLQLAPSIEHQSAAMLSILERYKWHQFSVVTSQIA 263
            ..::.:..:|::..:...|.:......::...|...||:.|:..||.|::.|.||.||:||:...
Human   166 DFISSHTFVPILGIHGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFP 230

  Fly   264 GHDDFVQAVRERVA------EMQEHFKFTILNSIVVTRTSDLMELVNSEARVMLLYATQTEAITI 322
            |:.:|:..|:..|.      :||.  ..|:..|....:|...::.::|.  |:|||.::.||:.|
Human   231 GYREFISFVKTTVDNSFVGWDMQN--VITLDTSFEDAKTQVQLKKIHSS--VILLYCSKDEAVLI 291

  Fly   323 LRAAEEMKLTGENYVWVVSQSVIEKKD-AHSQFPVGMLGVHFDTSSAALMNEISNAIKIYSYGVE 386
            |..|..:.|||.::.|:|...|....: ...:||.|::.|.:|....:|...:.:.|.|.:....
Human   292 LSEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGIGILTTAAS 356

  Fly   387 AYLTDPANRDRRLTTQSLSCEDEGRGRWDNGEI----FFKYLRNVSIEGDLNKPNIEFTADGDLR 447
            :.|    .:...:.....||    .|:.:..|:    ...::.||:.:|    .::.||.:|...
Human   357 SML----EKFSYIPEAKASC----YGQMERPEVPMHTLHPFMVNVTWDG----KDLSFTEEGYQV 409

  Fly   448 SAELKIMNLRPSANNKNLVWEEIGVWKSWETQKLDIRDIAWPG-NSHAPPQGVPEKFHLKITFLE 511
            ...|.::.|     ||:..||::|   .||...|.:|...||. .|.:..:  |:..||.|..||
Human   410 HPRLVVIVL-----NKDREWEKVG---KWENHTLSLRHAVWPRYKSFSDCE--PDDNHLSIVTLE 464

  Fly   512 EAPYINLSPADPVSGKCLMDRGVLCR--VAADHEMAADIDVGQAHRNESFYQCCSGFCIDLLEKF 574
            |||::.:...||::..|:.:. |.||  |..::.....::|         .:||.|||||:|:|.
Human   465 EAPFVIVEDIDPLTETCVRNT-VPCRKFVKINNSTNEGMNV---------KKCCKGFCIDILKKL 519

  Fly   575 AEELGFTYELVRVEDGKWGTLENGKWNGLIADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETG 639
            :..:.|||:|..|.:||.|...|..|||:|.::|.::..|.:.||.||.||..|||||.||:|||
Human   520 SRTVKFTYDLYLVTNGKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETG 584

  Fly   640 IAIVVAKRTGIISPTAFLEPFDTASWMLVGIVAIQAATFMIFLFEWLSPSGYDMKLYLQNTNVTP 704
            |:::|::..|.:||:||||||..:.|:::.::.:..:...:|:||:.||.||:..|........|
Human   585 ISVMVSRSNGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGP 649

  Fly   705 YRFSLFRTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAAFMITREEFHE 769
             .|::.:..||:|.::|..:|.|.:|:|.||:.|.:|||.|||:|||.||||||||||..|...:
Human   650 -SFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQ 713

  Fly   770 FSGLNDSRLVHPFSHKPSFKFGTIPYSHTDSTIHKYFNVMHNYMRQYNKTSVADGVAAVLNGNLD 834
            .:||:|.:...|..:.|.|:|||:|...|:..|...:..||.||.::|:..|.|.:.::..|.||
Human   714 VTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFNQKGVEDALVSLKTGKLD 778

  Fly   835 SFIYDGTVLDYLVAQDEDCRLMTVGSWY--AMTGYGLAFSRNSKYVQMFNKRLLEFRANGDLERL 897
            :||||..||:|...:||.|:|:|:||.|  |.||||:|..:.|.:.:..:..||:|..:|::|.|
Human   779 AFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEEL 843

  Fly   898 RRYWMTGTCRPGKQEHKSSDPLALEQFLSAFLLLMAGILLAALLLLLEHVYFKYIR 953
            ...|:||.|...|.|..||. |.::.....|.:|.|.:.|:.:..:.||:::..:|
Human   844 ETLWLTGICHNEKNEVMSSQ-LDIDNMAGVFYMLAAAMALSLITFIWEHLFYWKLR 898

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..485	CDD:380601	88/396 (22%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	163/409 (40%)
GRIN2A	XP_016878661.1	PBP1_iGluR_NMDA_NR2	84..439	CDD:380601	88/396 (22%)
		PBP2_iGluR_NMDA_Nr2	455..854	CDD:270436	163/409 (40%)
		NMDAR2_C	891..1516	CDD:463148	2/8 (25%)