DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar2 and GRIN2A

DIOPT Version :9

Sequence 1:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster
Sequence 2:	XP_016878661.1	Gene:	GRIN2A / 2903	HGNCID:	4585	Length:	1516	Species:	Homo sapiens

Alignment Length:	901	Identity:	276/901 - (30%)
Similarity:	463/901 - (51%)	Gaps:	78/901 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 TLLILDTRSCQGLRLTNGGGSLSKGAAANKEQLNIGLIAPHTNFGKREYLRSINNAVTGLTKTRG 133
            |||:|..      .|...|.:.|..|......|||.::..|::......||::    .|..:..|
Human    60 TLLVLPA------LLVWRGPAPSAAAEKGPPALNIAVMLGHSHDVTERELRTL----WGPEQAAG 114

  Fly   134 AKLTFLKDYSFEQKNIHFDMMSLTPSPTAILSTLCKEFLRVNVSAILYMMNNEQFGHSTASAQYF 198
            ..|         ..|:...:|:.| .|.::::.:|.......:..:::..:.:|    .|.||..
Human   115 LPL---------DVNVVALLMNRT-DPKSLITHVCDLMSGARIHGLVFGDDTDQ----EAVAQML 165

  Fly   199 LQLAGYLGIPVISWNADNSGLERRASQSTLQLQLAPSIEHQSAAMLSILERYKWHQFSVVTSQIA 263
            ..::.:..:|::..:...|.:......::...|...||:.|:..||.|::.|.||.||:||:...
Human   166 DFISSHTFVPILGIHGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFP 230

  Fly   264 GHDDFVQAVRERVA------EMQEHFKFTILNSIVVTRTSDLMELVNSEARVMLLYATQTEAITI 322
            |:.:|:..|:..|.      :||.  ..|:..|....:|...::.::|.  |:|||.::.||:.|
Human   231 GYREFISFVKTTVDNSFVGWDMQN--VITLDTSFEDAKTQVQLKKIHSS--VILLYCSKDEAVLI 291

  Fly   323 LRAAEEMKLTGENYVWVVSQSVIEKKD-AHSQFPVGMLGVHFDTSSAALMNEISNAIKIYSYGVE 386
            |..|..:.|||.::.|:|...|....: ...:||.|::.|.:|....:|...:.:.|.|.:....
Human   292 LSEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGIGILTTAAS 356

  Fly   387 AYLTDPANRDRRLTTQSLSCEDEGRGRWDNGEI----FFKYLRNVSIEGDLNKPNIEFTADGDLR 447
            :.|    .:...:.....||    .|:.:..|:    ...::.||:.:|    .::.||.:|...
Human   357 SML----EKFSYIPEAKASC----YGQMERPEVPMHTLHPFMVNVTWDG----KDLSFTEEGYQV 409

  Fly   448 SAELKIMNLRPSANNKNLVWEEIGVWKSWETQKLDIRDIAWPG-NSHAPPQGVPEKFHLKITFLE 511
            ...|.::.|     ||:..||::|   .||...|.:|...||. .|.:..:  |:..||.|..||
Human   410 HPRLVVIVL-----NKDREWEKVG---KWENHTLSLRHAVWPRYKSFSDCE--PDDNHLSIVTLE 464

  Fly   512 EAPYINLSPADPVSGKCLMDRGVLCR--VAADHEMAADIDVGQAHRNESFYQCCSGFCIDLLEKF 574
            |||::.:...||::..|:.:. |.||  |..::.....::|         .:||.|||||:|:|.
Human   465 EAPFVIVEDIDPLTETCVRNT-VPCRKFVKINNSTNEGMNV---------KKCCKGFCIDILKKL 519

  Fly   575 AEELGFTYELVRVEDGKWGTLENGKWNGLIADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETG 639
            :..:.|||:|..|.:||.|...|..|||:|.::|.::..|.:.||.||.||..|||||.||:|||
Human   520 SRTVKFTYDLYLVTNGKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETG 584

  Fly   640 IAIVVAKRTGIISPTAFLEPFDTASWMLVGIVAIQAATFMIFLFEWLSPSGYDMKLYLQNTNVTP 704
            |:::|::..|.:||:||||||..:.|:::.::.:..:...:|:||:.||.||:..|........|
Human   585 ISVMVSRSNGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGP 649

  Fly   705 YRFSLFRTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAAFMITREEFHE 769
             .|::.:..||:|.::|..:|.|.:|:|.||:.|.:|||.|||:|||.||||||||||..|...:
Human   650 -SFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQ 713

  Fly   770 FSGLNDSRLVHPFSHKPSFKFGTIPYSHTDSTIHKYFNVMHNYMRQYNKTSVADGVAAVLNGNLD 834
            .:||:|.:...|..:.|.|:|||:|...|:..|...:..||.||.::|:..|.|.:.::..|.||
Human   714 VTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFNQKGVEDALVSLKTGKLD 778

  Fly   835 SFIYDGTVLDYLVAQDEDCRLMTVGSWY--AMTGYGLAFSRNSKYVQMFNKRLLEFRANGDLERL 897
            :||||..||:|...:||.|:|:|:||.|  |.||||:|..:.|.:.:..:..||:|..:|::|.|
Human   779 AFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEEL 843

  Fly   898 RRYWMTGTCRPGKQEHKSSDPLALEQFLSAFLLLMAGILLAALLLLLEHVYFKYIR 953
            ...|:||.|...|.|..||. |.::.....|.:|.|.:.|:.:..:.||:::..:|
Human   844 ETLWLTGICHNEKNEVMSSQ-LDIDNMAGVFYMLAAAMALSLITFIWEHLFYWKLR 898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	90/401 (22%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	163/409 (40%)
		Lig_chan	665..928	CDD:278489	101/264 (38%)
GRIN2A	XP_016878661.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156044
Domainoid	1	1.000	214	1.000	Domainoid score	I2727
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	455	1.000	Inparanoid score	I1591
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D279143at33208
OrthoFinder	1	1.000	-	-		FOG0000775
OrthoInspector	1	1.000	-	-		otm40973
orthoMCL	1	0.900	-	-		OOG6_102799
Panther	1	1.100	-	-	LDO	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.760