Protein Alignment Nmdar2 and GRIN1

DIOPT Version :9

• Sequence 1: NP_001014714.1
• Gene: Nmdar2 / 31107
• FlyBaseID: FBgn0053513
• Length: 1083
• Species: Drosophila melanogaster
• Sequence 2: XP_005266130.1
• Gene: GRIN1 / 2902
• HGNCID: 4584
• Length: 959
• Species: Homo sapiens
• Alignment Length: 1074
• Identity: 283/1074 - (26%)
• Similarity: 454/1074 - (42%)
• Gaps: 215/1074 - (20%)

  Fly    60 ISLLLLTVLTLLILDTRSCQGLRLTNGGGSLSKGAAANKEQLNIGLIAPHTNFGKREYLRSINNA 124
            :|.:.|..|.||.    ||...|           ||.:.:.:|||.:     ...|::.:....|
Human     1 MSTMRLLTLALLF----SCSVAR-----------AACDPKIVNIGAV-----LSTRKHEQMFREA 45

  Fly   125 VTGLTKTRGAKLTFLKDYSFEQKNIHFDMMSLTPSPTAILSTL--CKEFLRVNVSAILYM---MN 184
            |....|..|:            ..|..:..|:|..|.||...|  |::.:...|.|||..   ..
Human    46 VNQANKRHGS------------WKIQLNATSVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTP 98

  Fly   185 NEQFGHSTASAQYFLQLAGYLGIPVISWNADNSGLERRA---SQSTLQ---LQLAPSIEHQSAAM 243
            |:.|..:..|     ..||:..|||:       ||..|.   |..::.   |:..|...|||:..
Human    99 NDHFTPTPVS-----YTAGFYRIPVL-------GLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVW 151

  Fly   244 LSILERYKWHQFSVVTSQIAGHDDFVQAVRERVAEMQEHFK-------FTILNSIVVTR------ 295
            ..::..|.|:...::.|.    |...:|.::|:..:.|..:       :..|:.:....
Human   152 FEMMRVYSWNHIILLVSD----DHEGRAAQKRLETLLEERESKSKKRNYENLDQLSYDNKRGPKA 212

  Fly   296 -------------TSDLMELVNSEARVMLLYATQTEAITILRAAEEMKLTGENYVWVVSQSVIEK 347
                         |:.|||....||||::|.|::.:|.|:.|||..:.:||..|||:|.:..| .
Human   213 EKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREI-S 276

  Fly   348 KDAHSQFPVGMLGVHFDTSSAALMN------EISNAIKIYSYGVEAYL-----TDPANRDRRLTT 401
            .:|....|.|:||:.       |:|      .||:|:.:.:..|...|     |||..
Human   277 GNALRYAPDGILGLQ-------LINGKNESAHISDAVGVVAQAVHELLEKENITDPPR------- 327

  Fly   402 QSLSCEDEGRGRWDNGEIFFKYLRNVSIEGDLNKPNIEFTADGDLRSAELKIMNLRPSANNKNLV 466
               .|.. ....|..|.:|.:.|.: |...|.....:||..|||.:.|...||||:    |:.||
Human   328 ---GCVG-NTNIWKTGPLFKRVLMS-SKYADGVTGRVEFNEDGDRKFANYSIMNLQ----NRKLV 383

  Fly   467 WEEIGVWKSWETQKLDIRDIAWPGNSHAPPQGVPEKFHLKITFLEEAPYINLSP----------- 520
              ::|::........| |.|.|||.....|:|......|||..:.:.|::.:.|
Human   384 --QVGIYNGTHVIPND-RKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTCKEEF 445

  Fly   521 ---ADPVSGKCLMDRGVLCRVAADHEMAADIDVGQAHRNESFYQCCSGFCIDLLEKFAEELGFTY 582
               .|||       :.|:|        ....|........:..|||.|||||||.|.|..:.|||
Human   446 TVNGDPV-------KKVIC--------TGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTY 495

  Fly   583 ELVRVEDGKWGTLE-----NGK-WNGLIADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGIA 641
            |:..|.|||:||.|     |.| |||::.:|::.:.||::..|.||.||...::||:||...|:.
Human   496 EVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLT 560

  Fly   642 IVVAKRTGIISPTAFLEPFDTASWMLVGIVAIQAATFMIFLFEWLSPSGYDMKLYLQNTNVTPYR 706
            |:|.|.....:..:|::||.:..|:|||: ::.....|::|.:..||.|   :..:.:.......
Human   561 ILVKKEIPRSTLDSFMQPFQSTLWLLVGL-SVHVVAVMLYLLDRFSPFG---RFKVNSEEEEEDA 621

  Fly   707 FSLFRTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAAFMITREEFHEFS 771
            .:|....|..|.||..:.:...:||.|::|.:..|||.||::.:|.||||||||::........:
Human   622 LTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERIT 686

  Fly   772 GLNDSRLVHPFSHKPSFKFGTIPYSHTDSTIHKYF------NVMHNYMRQYNKTSVADGVAAVLN 830
            |:||.||.:|   ...|.:.|:..|..|.    ||      :.|:.:|.::|..|.|:.:.||.:
Human   687 GINDPRLRNP---SDKFIYATVKQSSVDI----YFRRQVELSTMYRHMEKHNYESAAEAIQAVRD 744

  Fly   831 GNLDSFIYDGTVLDYLVAQDEDCRLMTVGSWYAMTGYGLAFSRNSKYVQMFNKRLLEFRANGDLE 895
            ..|.:||:|..||::..:|  .|.|:|.|..:..:|:|:...::|.:.|..:..:|:...||.:|
Human   745 NKLHAFIWDSAVLEFEASQ--KCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFME 807

  Fly   896 RLRRYWMTGTCRPGKQEHKSSDP--LALEQFLSAFLLLMAGILLAALLLLLEHVYFKY------- 951
            .|.:.|:    |..:.:.:|:.|  |..|.....|:|:..||:....|:.:|..|.::
Human   808 DLDKTWV----RYQECDSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRHKDARRKQ 868

  Fly   952 ----------IRKRLAKKDGGHCCALISLSMGKSLTFRGAVFEATEILKKHRCNDPICDTHLWKV 1006
                      .||.|..:..|..    .....|..|||..........|:.|.:.   ||.....
Human   869 MQLAFAAVNVWRKNLQDRKSGRA----EPDPKKKATFRAITSTLASSFKRRRSSK---DTSTGGG 926

  Fly  1007 KHELDMSRLRVRQLEKVMDKHGIKAP--QLRLAS 1038
            :..|.      .|.:.|:.:..|:..  ||:|.|
Human   927 RGALQ------NQKDTVLPRRAIEREEGQLQLCS 954

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	107/438 (24%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	130/431 (30%)
		Lig_chan	665..928	CDD:278489	77/270 (29%)
GRIN1	XP_005266130.1	PBP1_iGluR_NMDA_NR1	25..404	CDD:380602	107/438 (24%)
		PBP2_iGluR_NMDA_Nr1	416..820	CDD:270437	131/435 (30%)
		CaM_bdg_C0	856..884	CDD:402271	3/27 (11%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910