DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nmdar2 and GRIK4

DIOPT Version :9

Sequence 1:NP_001014714.1 Gene:Nmdar2 / 31107 FlyBaseID:FBgn0053513 Length:1083 Species:Drosophila melanogaster
Sequence 2:NP_001269399.1 Gene:GRIK4 / 2900 HGNCID:4582 Length:956 Species:Homo sapiens


Alignment Length:968 Identity:222/968 - (22%)
Similarity:399/968 - (41%) Gaps:219/968 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    57 SGPISLLLLTVLTLLILDTRSCQGLRLTNGGGSLSKGAAANKEQLNIGLIAPHTNFGKREYLRSI 121
            |.|: :||...|.::.....|.:...:.:.....|:|     |:|:|.|..           ..|
Human     5 SAPL-VLLPAWLVMVACSPHSLRIAAILDDPMECSRG-----ERLSITLAK-----------NRI 52

  Fly   122 NNAVTGLTKTRGAKLTF--LKDYSFEQKNIHFDMM----------SLTPSPTAILSTLCKEFLRV 174
            |.|...|.|.:.....|  |:|..:|.......::          |.:|:.::|:|.:|.|    
Human    53 NRAPERLGKAKVEVDIFELLRDSEYETAETMCQILPKGVVAVLGPSSSPASSSIISNICGE---- 113

  Fly   175 NVSAILYMMNNEQFGHSTASAQYFLQLAGYLGIPVISWNADNSGLERRASQSTLQLQLAPSIEHQ 239
                       ::..|...:.:.|::.                     ..|....|.|.||....
Human   114 -----------KEVPHFKVAPEEFVKF---------------------QFQRFTTLNLHPSNTDI 146

  Fly   240 SAAMLSILERYKWHQFSVVTSQIAGHDDFVQAVRERVAEMQEHFK-FTILNSIVVTRTSD----- 298
            |.|:..||     :.|:..|:.:      :.|..|.:..:::..: |.|....:..|..|     
Human   147 SVAVAGIL-----NFFNCTTACL------ICAKAECLLNLEKLLRQFLISKDTLSVRMLDDTRDP 200

  Fly   299 ---LMELVNSEARVMLLYATQTEAITILRAAEEMKLTGENYVWVVS--QSVIEKKDAHSQFPVGM 358
               |.|:.:.:...::::|..:.:.|||..|.|:.:....|.::.:  :..:::.|:.....|.:
Human   201 TPLLKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAYYTYIFTNLEFSLQRMDSLVDDRVNI 265

  Fly   359 LGVHFDTSSAALMNEISNAIK--------------------IYSYGVEAYLT--DPANRDRRLTT 401
            ||......|.|...|.:.::.                    :....|.|.:|  ...||.:.:..
Human   266 LGFSIFNQSHAFFQEFAQSLNQSWQENCDHVPFTGPALSSALLFDAVYAVVTAVQELNRSQEIGV 330

  Fly   402 QSLSCEDEGRGR-WDNGEIFFKYLRNVSIEGDLNKPNIEFTADGDLRSAELKIMNLRPSANNKNL 465
            :.|||   |..: |.:|.....|||.|.:||...  :|||.:.|...:..|||:....:.     
Human   331 KPLSC---GSAQIWQHGTSLMNYLRMVELEGLTG--HIEFNSKGQRSNYALKILQFTRNG----- 385

  Fly   466 VWEEIGVWKSWETQKLDIRDIAWPGNSHAPPQGVPEKFH---LKITFLEEAPYINLSPADPVSGK 527
             :.:||.|...|...:|         ||.....:.:...   |.:|.:.|.||:.|.        
Human   386 -FRQIGQWHVAEGLSMD---------SHLYASNISDTLFNTTLVVTTILENPYLMLK-------- 432

  Fly   528 CLMDRGVLCRVAADHEMAADIDVGQAHRNESFYQCCSGFCIDLLEKFAEELGFTYELVRVEDGKW 592
                        .:|:        :...|:.:    .|||:|:|::.||.|.|.|::..|.||.:
Human   433 ------------GNHQ--------EMEGNDRY----EGFCVDMLKELAEILRFNYKIRLVGDGVY 473

  Fly   593 GTLE-NGKWNGLIADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGIAIV----VAKRTGIIS 652
            |..| ||.|.|::.:|:.||.|:.:..|.|..|||.|:|||:|||..||:|:    :.::.|..|
Human   474 GVPEANGTWTGMVGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFS 538

  Fly   653 PTAFLEPFDTASW--MLVGIVAIQAATFMIFL---FEWLSP----SGYDMKLYLQNTNVTPYRFS 708
               ||:||....|  ||:..:|:....|::..   :||.||    .|        ..|:...::|
Human   539 ---FLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQG--------RCNLLVNQYS 592

  Fly   709 LFRTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAAFMITREEFHEFSGL 773
            |..:.|.......|....: :||..::|.::.||..|.::.::.||||||||:..:........:
Human   593 LGNSLWFPVGGFMQQGSTI-APRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESV 656

  Fly   774 NDSRLVHPFSHKPSFKFGTIPYSHTDSTI-------HKYFNVMHNYMRQYNK------TSVADGV 825
            :|      .:.:.:.::|||   |..|::       ::.:..|.|||  |:|      .|..:|:
Human   657 DD------LADQTAIEYGTI---HGGSSMTFFQNSRYQTYQRMWNYM--YSKQPSVFVKSTEEGI 710

  Fly   826 AAVLNGNLDSFIYDGTVLDYLVAQDEDCRLMTVGSWYAMTGYGLAFSRNSKYVQMFNKRLLEFRA 890
            |.|||.|. :|:.:.|:.:|.  :..:|.|..:|......|||:.....|.:...|:..:|:.:.
Human   711 ARVLNSNY-AFLLESTMNEYY--RQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQE 772

  Fly   891 NGDLERLRRYWMTGTCRPGKQEHKSSDPLALEQFLSAFLLLMAGILLAALLLLLEHVY 948
            |..||.|:|.|..|...|.:::|::.. |.:|.....|::|:.|:::|..:.:||.::
Human   773 NNRLEILKRKWWEGGKCPKEEDHRAKG-LGMENIGGIFVVLICGLIVAIFMAMLEFLW 829

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nmdar2NP_001014714.1 PBP1_iGluR_NMDA_NR2 99..490 CDD:107373 83/436 (19%)
PBP2_iGluR_NMDA_Nr2 502..908 CDD:270436 119/435 (27%)
Lig_chan 665..928 CDD:278489 71/284 (25%)
GRIK4NP_001269399.1 PBP1_iGluR_Kainate_KA1_2 26..400 CDD:107389 84/447 (19%)
ANF_receptor 43..382 CDD:279440 77/401 (19%)
PBP2_iGluR_kainate_KA1 415..785 CDD:270442 118/427 (28%)
Lig_chan 547..816 CDD:278489 73/292 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 863..889
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 931..956
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165155779
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1052
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.740

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