DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nmdar2 and GRIK3

DIOPT Version :9

Sequence 1:NP_001014714.1 Gene:Nmdar2 / 31107 FlyBaseID:FBgn0053513 Length:1083 Species:Drosophila melanogaster
Sequence 2:NP_000822.2 Gene:GRIK3 / 2899 HGNCID:4581 Length:919 Species:Homo sapiens


Alignment Length:940 Identity:212/940 - (22%)
Similarity:382/940 - (40%) Gaps:179/940 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   143 SFEQKNIHF-DMMSLTPSPTAILSTLCKEFLRVNVSAILYMMNNEQFGHSTASAQYFLQ-LAGYL 205
            :::.:.||| |....|       ...|.: |.:.|.||        ||.|..|....:| :...|
Human    80 TYDIQRIHFHDSFEAT-------KKACDQ-LALGVVAI--------FGPSQGSCTNAVQSICNAL 128

  Fly   206 GIPVISWNADNSGLERRASQSTLQLQLAPSIEHQSAAMLSILERYKWHQFSVVTSQIAGHDDFVQ 270
            .:|.|.....:..|:   ::.|..:.|.|.....|.|:|.:::..||...:||      :||...
Human   129 EVPHIQLRWKHHPLD---NKDTFYVNLYPDYASLSHAILDLVQYLKWRSATVV------YDDSTG 184

  Fly   271 AVRER---VAEMQEHFKFTILNSIVVTRTSD--LMELVNSEARVMLLYATQTEAITILRAAEEMK 330
            .:|.:   :|..:.:.:..|....:.:..|.  |.|:.......::...:.|.|..||:.|..|.
Human   185 LIRLQELIMAPSRYNIRLKIRQLPIDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMG 249

  Fly   331 LTGENYVW-------------------------------------VVSQSVIEKKDAHSQFPVGM 358
            :..|.|.:                                     :|.:..:|:..|..:...|:
Human   250 MMTEYYHFIFTTLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWSMERLQAAPRSESGL 314

  Fly   359 L-GVHFDTSSAALMNEISNAIKIYSYGVEAYLTDPANRDRRLTTQSLSCEDEGRGRWDNGEIFFK 422
            | ||..  :.|||:.:..:.:.:      .|...|     ::|..||.|  .....|..|..|..
Human   315 LDGVMM--TDAALLYDAVHIVSV------CYQRAP-----QMTVNSLQC--HRHKAWRFGGRFMN 364

  Fly   423 YLRNVSIEGDLNKPNIEFTADGDLRS-AELKIMNLRPSANNKNLVWEEIGVWKSWETQKLDIRDI 486
            :::....||...:  |.|.....||: .:|.|::|:...      .|::|||.  ....|:|.::
Human   365 FIKEAQWEGLTGR--IVFNKTSGLRTDFDLDIISLKEDG------LEKVGVWS--PADGLNITEV 419

  Fly   487 AWPGNSHAPPQGVPEKFHLKITFLEEAPYINLSPADPVSGKCLMDRGVLCRVAADHEMAADIDVG 551
            | .|........:..:..:..|.||| |::....:|..                           
Human   420 A-KGRGPNVTDSLTNRSLIVTTVLEE-PFVMFRKSDRT--------------------------- 455

  Fly   552 QAHRNESFYQCCSGFCIDLLEKFAEELGFTYELVRVEDGKWGTLEN-GKWNGLIADLVNRKTDMV 615
             .:.|:.|    .|:|||||::.|..|||:||:..|||||:|..:: |:|||::.:|::.|.|:.
Human   456 -LYGNDRF----EGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLA 515

  Fly   616 LTSLMINTEREAVVDFSEPFMETGIAIVVAKRTGIISPT--AFLEPFDTASWM--LVGIVAIQAA 676
            :..|.|...||..:|||:|||..|::|:..|..| .:|:  :||.|.....||  |:..:.:...
Human   516 VAPLTITHVREKAIDFSKPFMTLGVSILYRKPNG-TNPSVFSFLNPLSPDIWMYVLLAYLGVSCV 579

  Fly   677 TFMIFLF---EWLSPSGYDMKLYLQNTNVTPYRFSLFRTYWLVWAVLFQAAVHVDSPRGFTSRFM 738
            .|:|..|   ||     ||.......:.|....|:|..::|.....|.|....: .|:..::|.:
Human   580 LFVIARFSPYEW-----YDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQGSEL-MPKALSTRII 638

  Fly   739 TNVWALFAVVFLAIYTANLAAFMITREEFHEFSGLNDSRLVHPFSHKPSFKFGTIPYSHT----- 798
            ..:|..|.::.::.||||||||:............:|      .:.:...::|.:....|     
Human   639 GGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADD------LAKQTKIEYGAVKDGATMTFFK 697

  Fly   799 ---DSTIHKYFNVMHNYMRQYNKTSVADGVAAVLNGNLDSFIYDGTVLDYLVAQDEDCRLMTVGS 860
               .||..|.:..|.:......|.: .:|:...|..:. :.:.:.|.::|:.  ..:|.|..:|.
Human   698 KSKISTFEKMWAFMSSKPSALVKNN-EEGIQRALTADY-ALLMESTTIEYVT--QRNCNLTQIGG 758

  Fly   861 WYAMTGYGLAFSRNSKYVQMFNKRLLEFRANGDLERLRRYWMTGTCRPGKQEHKSSDPLALEQFL 925
            .....|||:.....|.|.......:|:.:....|..::..|..|:..| ::|:|.:..|.:::..
Human   759 LIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRGSGCP-EEENKEASALGIQKIG 822

  Fly   926 SAFLLLMAGILLAALLLLLEHVYFKYIRKRLAKKDGGHCCALISLSMGKSLTFRGAVFEATEILK 990
            ..|::|.||::|:.|:.:.|.||  .:|| .|:::....|:.::..:..|||.:..|        
Human   823 GIFIVLAAGLVLSVLVAVGEFVY--KLRK-TAEREQRSFCSTVADEIRFSLTCQRRV-------- 876

  Fly   991 KHRCNDPICDTHLWKVKHELDMSRLRVRQL 1020
            ||:...|:    :.|....::|.....|:|
Human   877 KHKPQPPM----MVKTDAVINMHTFNDRRL 902

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nmdar2NP_001014714.1 PBP1_iGluR_NMDA_NR2 99..490 CDD:107373 80/392 (20%)
PBP2_iGluR_NMDA_Nr2 502..908 CDD:270436 103/421 (24%)
Lig_chan 665..928 CDD:278489 56/275 (20%)
GRIK3NP_000822.2 PBP1_iGluR_Kainate_GluR5_7 34..417 CDD:107388 78/386 (20%)
ANF_receptor 55..398 CDD:279440 72/359 (20%)
PBP2_iGluR_Kainate_GluR7 433..801 CDD:270441 102/417 (24%)
Lig_chan 564..832 CDD:278489 59/284 (21%)
Glutamate binding. /evidence=ECO:0000250 690..692 0/1 (0%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165156240
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1052
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.740

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