back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar2 and GRIK2

DIOPT Version :9

Sequence 1:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster
Sequence 2:	NP_068775.1	Gene:	GRIK2 / 2898	HGNCID:	4580	Length:	908	Species:	Homo sapiens

Alignment Length:	964	Identity:	223/964 - (23%)
Similarity:	383/964 - (39%)	Gaps:	211/964 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 LRSINNAVTGLTKTRGAKLTF------LKDYSFEQKNIHFDMMSLTPSPTAILSTLCKEFLRVNV 176
            :.:||...|.|..|   .||:      |.| |||......|.:||                  .|
Human    61 VNTINRNRTLLPNT---TLTYDTQKINLYD-SFEASKKACDQLSL------------------GV 103

  Fly   177 SAILYMMNNEQFGHS-TASAQYFLQLAGYLGIPVIS--WN---ADNSGLERRASQSTLQLQLAPS 235
            :||        ||.| ::||.....:...||:|.|.  |.   :||        :.:..:.|.|.
Human   104 AAI--------FGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDN--------KDSFYVSLYPD 152

  Fly   236 IEHQSAAMLSILERYKWHQFSVVTSQIAGHDDFVQAVR-ERVAEMQEHFKFTILNSIVVTRTSD- 298
            ....|.|:|.:::.:||...:||      :||....:| :.:.:....:...:....:...|.|
Human   153 FSSLSRAILDLVQFFKWKTVTVV------YDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKDA 211

  Fly   299 ---LMELVNSEARVMLLYATQTEAITILRAAEEMKLTGENYVWVVS------------------- 341
               |.|:...:...::...:...|..||:.|..|.:..|.|.::.:
Human   212 KPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNM 276

  Fly   342 -------------QSVIEKKDAHS-QFP----VGMLGVHFDTSSAALMNEISNAIKIYSYGVEAY 388
                         .|:|||..... |.|    .|:|. .|.|:.||||.:   |:.:.|..|:.:
Human   277 TGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLD-GFMTTDAALMYD---AVHVVSVAVQQF 337

  Fly   389 LTDPANRDRRLTTQSLSCEDEGRGR-WDNGEIFFKYLRNVSIEGDLNKPNIEFTADGDLRS-AEL 451
                    .::|..||.|   .|.: |..|..|...::....||...:  |.|.....||: .:|
Human   338 --------PQMTVSSLQC---NRHKPWRFGTRFMSLIKEAHWEGLTGR--ITFNKTNGLRTDFDL 389

  Fly   452 KIMNLRPSANNKNLVWEEIGVWKSWETQKLDIRDIAWPGNSHAPPQGVPEKF---HLKITFLEEA 513
            .:::|:.....|...|:........|:||             ..|..:.:..   .|.:|.:.|.
Human   390 DVISLKEEGLEKIGTWDPASGLNMTESQK-------------GKPANITDSLSNRSLIVTTILEE 441

  Fly   514 PYINLSPAD-PVSGKCLMDRGVLCRVAADHEMAADIDVGQAHRNESFYQCCSGFCIDLLEKFAEE 577
            ||:....:| |:.|                             |:.|    .|:|||||.:.:..
Human   442 PYVLFKKSDKPLYG-----------------------------NDRF----EGYCIDLLRELSTI 473

  Fly   578 LGFTYELVRVEDGKWGTLE--NGKWNGLIADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGI 640
            ||||||:..|||||:|..:  ||:|||::.:|::.|.|:.:..|.|...||.|:|||:|||..||
Human   474 LGFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGI 538

  Fly   641 AIVVAKRTGIISP--TAFLEPFDTASWM--LVGIVAIQAATFMIFLF---EWLSPSGYDMKLYLQ 698
            :|:..|..| .:|  .:||.|.....||  |:..:.:....|:|..|   ||.:|...:     .
Human   539 SILYRKPNG-TNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCN-----P 597

  Fly   699 NTNVTPYRFSLFRTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAAFMIT 763
            :::|....|:|..::|.....|.|....: .|:..::|.:..:|..|.::.::.||||||||:..
Human   598 DSDVVENNFTLLNSFWFGVGALMQQGSEL-MPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTV 661

  Fly   764 REEFHEFSGLNDSRLVHPFSHKPSFKFGTIPYSHT--------DSTIHKYFNVMHNYMRQYNKTS 820
            ..........:|      .:.:...::|.:....|        .||..|.:..|.:..:.....|
Human   662 ERMESPIDSADD------LAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKS 720

  Fly   821 VADGVAAVLNGNLDSFIYDGTVLDYLVAQDEDCRLMTVGSWYAMTGYGLAFSRNSKYVQMFNKRL 885
            ..:|:..||..:. :|:.:.|.::::.  ..:|.|..:|......|||:.....|.|.......:
Human   721 NEEGIQRVLTSDY-AFLMESTTIEFVT--QRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAI 782

  Fly   886 LEFRANGDLERLRRYWMTGTCRPGKQEHKSSDPLALEQFLSAFLLLMAGILLAALLLLLEHVYFK 950
            |:.:..|.|..::..|..|...| ::|.|.:..|.::.....|::|.||::|:..:.:.|.:|..
Human   783 LQLQEEGKLHMMKEKWWRGNGCP-EEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKS 846

  Fly   951 YIRKRLAKKDGGHCCALI-----SLSMGKSLTFR---GAVFEATEILKKHRCND 996
            ....:|.|:  ..|.|::     ||...:.|..:   ..:.:..|::..|..||
Human   847 KKNAQLEKR--SFCSAMVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFND 898

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.