DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar2 and GRID2

DIOPT Version :9

Sequence 1:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster
Sequence 2:	XP_011530195.2	Gene:	GRID2 / 2895	HGNCID:	4576	Length:	1035	Species:	Homo sapiens

Alignment Length:	950	Identity:	221/950 - (23%)
Similarity:	374/950 - (39%)	Gaps:	226/950 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 INNAVTGLTK-----TRGAKLTFLKDYSFEQKNIHFDMMSLTPSPTAILSTLCKEFLRVNVSAIL 180
            :.:.||..|:     |||.                    :.|.||...|.....|.:...:.|::
Human    62 VRSGVTAATRMPLRETRGT--------------------NTTASPATALPQKTCELMNQGILALV 106

  Fly   181 YMMNNEQFG--HSTASAQY----FLQLAGYLGIPVISWNADNSGLERRASQSTLQLQLAPSIEHQ 239
            ..:.....|  .|.|.|.:    |:| ....|.|     ....||.|........|.:.|.: :.
Human   107 SSIGCTSAGSLQSLADAMHIPHLFIQ-RSTAGTP-----RSGCGLTRSNRNDDYTLSVRPPV-YL 164

  Fly   240 SAAMLSILERYKWHQFSVVTS---QIAGHDDFVQAVRERVAEMQEHFKFTILNSIVVT-----RT 296
            ...:|.::..|.|.:|.:...   .|.|..:|:..|.::..::........:|.::.|     |.
Human   165 HDVILRVVTEYAWQKFIIFYDSEYDIRGIQEFLDKVSQQGMDVALQKVENNINKMITTLFDTMRI 229

  Fly   297 SDLMELVNSEARVMLLYATQTEAITILRAAEEMKLTGENYVWVVSQSVIEKKDA----------- 350
            .:|....::..|.:|:....| |.:.:....|..|...:..|::....|...|.
Human   230 EELNRYRDTLRRAILVMNPAT-AKSFITEVVETNLVAFDCHWIIINEEINDVDVQELVRRSIGRL 293

  Fly   351 ---HSQFPVG-------MLGVHFDTSSA-------ALMNEISNAIKIYSYGVEAYLTDPANR--- 395
               ...|||.       ..|.|..:|:.       |...||||   :|.|.....|.:..::
Human   294 TIIRQTFPVPQNISQRCFRGNHRISSTLCDPKDPFAQNMEISN---LYIYDTVLLLANAFHKKLE 355

  Fly   396 DRRL-TTQSLSCEDEGRGRWDNGEIFFKYLRNVSIEG---------DLNKPNIEFTADGDLRSAE 450
            ||:. :..||||..:....|..|....:.::...:.|         :...||:.|...|.....|
Human   356 DRKWHSMASLSCIRKNSKPWQGGRSMLETIKKGGVSGLTGELEFGENGGNPNVHFEILGTNYGEE 420

  Fly   451 L-----KIMNLRPSANNKNLVWEEIGVWK-------SWETQKLD--IRDIAWPGNSHAPPQGVPE 501
            |     |...:||..:. ..:|.::|.|.       |...:||:  :|.:.
Human   421 LGRGVRKNERIRPQGST-GKIWPQLGCWNPVTGLNGSLTDKKLENNMRGVV-------------- 470

  Fly   502 KFHLKITFLEEAPYINLSPADPVSGKCLMDRGVLCRVAADHEMAADIDVGQAHRNESFYQCCSGF 566
               |::..:.|.|::.:|  :.|.||                             ...||   ||
Human   471 ---LRVVTVLEEPFVMVS--ENVLGK-----------------------------PKKYQ---GF 498

  Fly   567 CIDLLEKFAEELGFTYELVRVEDGKWGT-LENGKWNGLIADLVNRKTDMVLTSLMINTEREAVVD 630
            .||:|:..:..|||.||:....|.|:|: .|:|.||||:.:||.::.|:.:::|.|..:||.|||
Human   499 SIDVLDALSNYLGFNYEIYVAPDHKYGSPQEDGTWNGLVGELVFKRADIGISALTITPDRENVVD 563

  Fly   631 FSEPFMETGIAIVVAKRTGIISPTAFLEPFDTASW-------MLVGIVAIQAATFMIFLFEWLSP 688
            |:..:|:..:.:::.:....:...|.|.|||.:.|       :|||:        :::|..||:|
Human   564 FTTRYMDYSVGVLLRRAEKTVDMFACLAPFDLSLWACIAGTVLLVGL--------LVYLLNWLNP 620

  Fly   689 SGYDMKLYLQNTNVTPYRFSLFRTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIY 753
            ....|......|        |:.:.|.|:....|....|.... ..:|.|...|.|||::.::.|
Human   621 PRLQMGSMTSTT--------LYNSMWFVYGSFVQQGGEVPYTT-LATRMMMGAWWLFALIVISSY 676

  Fly   754 TANLAAFM-ITREEFHEFSGLNDSRLVHPFSHKPSFKFGTIPYSHTDSTIHKYFNV--------- 808
            |||||||: |||.| .....|.|      .|.:....:||:    .||.::::..:
Human   677 TANLAAFLTITRIE-SSIQSLQD------LSKQTEIPYGTV----LDSAVYEHVRMKGLNPFERD 730

  Fly   809 -MHNYM-RQYNKTSVAD--------GVAAVLNGNLDSFIYDGTVLDYLVAQDEDCRLMTVGSWYA 863
             |::.| |..|:::.::        |:..|..||. :|::|..||:|:...|.||...|:|:..|
Human   731 SMYSQMWRMINRSNGSENNVLESQAGIQKVKYGNY-AFVWDAAVLEYVAINDPDCSFYTIGNTVA 794

  Fly   864 MTGYGLAFSRNSKYVQMFNKRLLEFRANGDLERLRRYW--MTGTCRPGKQEHKSSD------PLA 920
            ..|||:|....|.|..:|::|:||.:.|||::.|:..|  ..|.|    ..:.|.|      .|.
Human   795 DRGYGIALQHGSPYRDVFSQRILELQQNGDMDILKHKWWPKNGQC----DLYSSVDTKQKGGALD 855

  Fly   921 LEQFLSAFLLLMAGILLAALLLLLEHVYFKYIRKRLAKKD 960
            ::.|...|.:|.|||:|:..:.:||..:.|....|:..|:
Human   856 IKSFAGVFCILAAGIVLSCFIAMLETWWNKRKGSRVPSKE 895

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	85/442 (19%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	121/435 (28%)
		Lig_chan	665..928	CDD:278489	80/297 (27%)
GRID2	XP_011530195.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156079
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740