Protein Alignment Nmdar2 and GRID1

DIOPT Version :10

• Sequence 1: NP_001014714.1
• Gene: Nmdar2 / 31107
• FlyBaseID: FBgn0053513
• Length: 1083
• Species: Drosophila melanogaster
• Sequence 2: NP_060021.1
• Gene: GRID1 / 2894
• HGNCID: 4575
• Length: 1009
• Species: Homo sapiens
• Alignment Length: 862
• Identity: 206/862 - (23%)
• Similarity: 342/862 - (39%)
• Gaps: 211/862 - (24%)

  Fly   156 LTPSPTAILSTLC-KEFLRVNVSAILYMMNN---EQF------GHSTASAQYFLQLAGYLGIPVI 210
            |.|||.....||. :..:|:| ..:|.::..   ::|      .:.....|.||..|..||:.|.
Human   130 LNPSPDGEAYTLASRPPVRLN-DVMLRLVTELRWQKFVMFYDSEYDIRGLQSFLDQASRLGLDVS 193

  Fly   211 SWNADNSGLERRASQSTLQLQLAPSIEHQSAAMLSI-----LERYK--WHQFSVVTSQIAGHDDF 268
            ....|.                  :|.|...::.:.     |.||:  ..:..::.|....|...
Human   194 LQKVDK------------------NISHVFTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHSFI 240

  Fly   269 VQAVRERVAEMQEHFKFTILNSIVVTRTSD--LMELVNSEARVMLLYATQTEAITILR-----AA 326
            .:||...:|....|:.|      |....||  :::||:|....|          |::|     |.
Human   241 NEAVETNLASKDSHWVF------VNEEISDPEILDLVHSALGRM----------TVVRQIFPSAK 289

  Fly   327 EEMKLTGENYVWVVSQSVIEKKDAHSQFPVGMLGVHFDTSSAALMNEISNAIKIYSYGVEAYLTD 391
            :..|.|..|:  .:|..:.:.::.:.|                 |.:|||   :|.|.....|.:
Human   290 DNQKCTRNNH--RISSLLCDPQEGYLQ-----------------MLQISN---LYLYDSVLMLAN 332

  Fly   392 PANR---DRRL-TTQSLSCEDEGRGRWDNGEIFFKYLRNVSIEGDLNKPNIEFTADGDLRSAELK 452
            ..:|   ||:. :..||:|..:....|:.|......::...|.|        .|.
Human   333 AFHRKLEDRKWHSMASLNCIRKSTKPWNGGRSMLDTIKKGHITG--------LTG---------- 379

  Fly   453 IMNLRPSANNKNLVWEEIGVWKSWETQKLDIRDIA-WP------GNSHAPPQGVP-EKFHLKITF 509
            :|..|..::|..:.:|.:|...| ||...|:|.:| |.      |:....|.|.. :...||:..
Human   380 VMEFREDSSNPYVQFEILGTTYS-ETFGKDMRKLATWDSEKGLNGSLQERPMGSRLQGLTLKVVT 443

  Fly   510 LEEAPYINLSPADPVSGKCLMDRGVLCRVAADHEMAADIDVGQAHRNESFYQCCSGFCIDLLEKF 574
            :.|.|::                           |.|:..:||..|.:       ||.||:|:..
Human   444 VLEEPFV---------------------------MVAENILGQPKRYK-------GFSIDVLDAL 474

  Fly   575 AEELGFTYELVRVEDGKWG-TLENGKWNGLIADLVNRKTDMVLTSLMINTEREAVVDFSEPFMET 638
            |:.|||.||:.:..||::| .|.|..|||:|.:|::::.|:.::::.|..|||:|||||:.:|:.
Human   475 AKALGFKYEIYQAPDGRYGHQLHNTSWNGMIGELISKRADLAISAITITPERESVVDFSKRYMDY 539

  Fly   639 GIAIVVAKRTGIISPTAFLEPFDTASWMLVGIVAIQAATFMIFLFEWLS-----------PSGYD 692
            .:.|::.|....||..:...|||.|.|..:. .||.....:||:...:.           ||.
Human   540 SVGILIKKPEEKISIFSLFAPFDFAVWACIA-AAIPVVGVLIFVLNRIQAVRAQSAAQPRPSA-- 601

  Fly   693 MKLYLQNTNVTPYRFSLFRTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANL 757
                         ..:|....|:|:....|.... .|......|.:...|.||.::..:.|||||
Human   602 -------------SATLHSAIWIVYGAFVQQGGE-SSVNSMAMRIVMGSWWLFTLIVCSSYTANL 652

  Fly   758 AAFM-ITREEFHEFSGLNDSRLVHPFSHKPSFKFGTIPYSHTDSTIHKYF-----------NVMH 810
            |||: ::|.:       |..|.....|.:....:||:    .||.:::||           :...
Human   653 AAFLTVSRMD-------NPIRTFQDLSKQVEMSYGTV----RDSAVYEYFRAKGTNPLEQDSTFA 706

  Fly   811 NYMRQYNKTSVAD--------GVAAVLNGNLDSFIYDGTVLDYLVAQDEDCRLMTVGSWYAMTGY 867
            ...|..:|...||        |:.....||. :|::|..|::|....|:||.:..:|:..:..||
Human   707 ELWRTISKNGGADNCVSSPSEGIRKAKKGNY-AFLWDVAVVEYAALTDDDCSVTVIGNSISSKGY 770

  Fly   868 GLAFSRNSKYVQMFNKRLLEFRANGDLERLRRYWMTGTCRPGKQEHKSSD----PLALEQFLSAF 928
            |:|....|.|..:|::|:||.:..|||:.|::.|.....|.....|.|:.    .|.|..|...|
Human   771 GIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHMGRCDLTSHASAQADGKSLKLHSFAGVF 835

  Fly   929 LLLMAGILLAALLLLLE 945
            .:|..|:|||.|:..||
Human   836 CILAIGLLLACLVAALE 852

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..485	CDD:380601	72/356 (20%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	113/437 (26%)
GRID1	NP_060021.1	Interaction with CBLN1. /evidence=ECO:0000250|UniProtKB:Q61627	21..436		78/381 (20%)
		PBP1_iGluR_delta_1	25..425	CDD:380615	76/370 (21%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	113/432 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	930..954