DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar2 and GRID1

DIOPT Version :9

Sequence 1:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster
Sequence 2:	NP_060021.1	Gene:	GRID1 / 2894	HGNCID:	4575	Length:	1009	Species:	Homo sapiens

Alignment Length:	862	Identity:	206/862 - (23%)
Similarity:	342/862 - (39%)	Gaps:	211/862 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 LTPSPTAILSTLC-KEFLRVNVSAILYMMNN---EQF------GHSTASAQYFLQLAGYLGIPVI 210
            |.|||.....||. :..:|:| ..:|.::..   ::|      .:.....|.||..|..||:.|.
Human   130 LNPSPDGEAYTLASRPPVRLN-DVMLRLVTELRWQKFVMFYDSEYDIRGLQSFLDQASRLGLDVS 193

  Fly   211 SWNADNSGLERRASQSTLQLQLAPSIEHQSAAMLSI-----LERYK--WHQFSVVTSQIAGHDDF 268
            ....|.                  :|.|...::.:.     |.||:  ..:..::.|....|...
Human   194 LQKVDK------------------NISHVFTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHSFI 240

  Fly   269 VQAVRERVAEMQEHFKFTILNSIVVTRTSD--LMELVNSEARVMLLYATQTEAITILR-----AA 326
            .:||...:|....|:.|      |....||  :::||:|....|          |::|     |.
Human   241 NEAVETNLASKDSHWVF------VNEEISDPEILDLVHSALGRM----------TVVRQIFPSAK 289

  Fly   327 EEMKLTGENYVWVVSQSVIEKKDAHSQFPVGMLGVHFDTSSAALMNEISNAIKIYSYGVEAYLTD 391
            :..|.|..|:  .:|..:.:.::.:.|                 |.:|||   :|.|.....|.:
Human   290 DNQKCTRNNH--RISSLLCDPQEGYLQ-----------------MLQISN---LYLYDSVLMLAN 332

  Fly   392 PANR---DRRL-TTQSLSCEDEGRGRWDNGEIFFKYLRNVSIEGDLNKPNIEFTADGDLRSAELK 452
            ..:|   ||:. :..||:|..:....|:.|......::...|.|        .|.
Human   333 AFHRKLEDRKWHSMASLNCIRKSTKPWNGGRSMLDTIKKGHITG--------LTG---------- 379

  Fly   453 IMNLRPSANNKNLVWEEIGVWKSWETQKLDIRDIA-WP------GNSHAPPQGVP-EKFHLKITF 509
            :|..|..::|..:.:|.:|...| ||...|:|.:| |.      |:....|.|.. :...||:..
Human   380 VMEFREDSSNPYVQFEILGTTYS-ETFGKDMRKLATWDSEKGLNGSLQERPMGSRLQGLTLKVVT 443

  Fly   510 LEEAPYINLSPADPVSGKCLMDRGVLCRVAADHEMAADIDVGQAHRNESFYQCCSGFCIDLLEKF 574
            :.|.|::                           |.|:..:||..|.:       ||.||:|:..
Human   444 VLEEPFV---------------------------MVAENILGQPKRYK-------GFSIDVLDAL 474

  Fly   575 AEELGFTYELVRVEDGKWG-TLENGKWNGLIADLVNRKTDMVLTSLMINTEREAVVDFSEPFMET 638
            |:.|||.||:.:..||::| .|.|..|||:|.:|::::.|:.::::.|..|||:|||||:.:|:.
Human   475 AKALGFKYEIYQAPDGRYGHQLHNTSWNGMIGELISKRADLAISAITITPERESVVDFSKRYMDY 539

  Fly   639 GIAIVVAKRTGIISPTAFLEPFDTASWMLVGIVAIQAATFMIFLFEWLS-----------PSGYD 692
            .:.|::.|....||..:...|||.|.|..:. .||.....:||:...:.           ||.
Human   540 SVGILIKKPEEKISIFSLFAPFDFAVWACIA-AAIPVVGVLIFVLNRIQAVRAQSAAQPRPSA-- 601

  Fly   693 MKLYLQNTNVTPYRFSLFRTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANL 757
                         ..:|....|:|:....|.... .|......|.:...|.||.::..:.|||||
Human   602 -------------SATLHSAIWIVYGAFVQQGGE-SSVNSMAMRIVMGSWWLFTLIVCSSYTANL 652

  Fly   758 AAFM-ITREEFHEFSGLNDSRLVHPFSHKPSFKFGTIPYSHTDSTIHKYF-----------NVMH 810
            |||: ::|.:       |..|.....|.:....:||:    .||.:::||           :...
Human   653 AAFLTVSRMD-------NPIRTFQDLSKQVEMSYGTV----RDSAVYEYFRAKGTNPLEQDSTFA 706

  Fly   811 NYMRQYNKTSVAD--------GVAAVLNGNLDSFIYDGTVLDYLVAQDEDCRLMTVGSWYAMTGY 867
            ...|..:|...||        |:.....||. :|::|..|::|....|:||.:..:|:..:..||
Human   707 ELWRTISKNGGADNCVSSPSEGIRKAKKGNY-AFLWDVAVVEYAALTDDDCSVTVIGNSISSKGY 770

  Fly   868 GLAFSRNSKYVQMFNKRLLEFRANGDLERLRRYWMTGTCRPGKQEHKSSD----PLALEQFLSAF 928
            |:|....|.|..:|::|:||.:..|||:.|::.|.....|.....|.|:.    .|.|..|...|
Human   771 GIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHMGRCDLTSHASAQADGKSLKLHSFAGVF 835

  Fly   929 LLLMAGILLAALLLLLE 945
            .:|..|:|||.|:..||
Human   836 CILAIGLLLACLVAALE 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	75/368 (20%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	113/437 (26%)
		Lig_chan	665..928	CDD:278489	70/297 (24%)
GRID1	NP_060021.1	Interaction with CBLN1. /evidence=ECO:0000250\|UniProtKB:Q61627	21..436		78/381 (20%)
		PBP1_iGluR_delta_1	25..423	CDD:107387	75/368 (20%)
		ANF_receptor	41..400	CDD:279440	68/344 (20%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	113/432 (26%)
		Lig_chan	564..841	CDD:278489	73/305 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	930..954
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155871
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740