back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar2 and GRIA4

DIOPT Version :9

Sequence 1:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster
Sequence 2:	NP_000820.4	Gene:	GRIA4 / 2893	HGNCID:	4574	Length:	902	Species:	Homo sapiens

Alignment Length:	997	Identity:	236/997 - (23%)
Similarity:	400/997 - (40%)	Gaps:	211/997 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 SCQGLRLTNGGGSLSKGAAANKEQLNIGLIAPHTNFGKREYLRSINNAVTGLTKTRGAKLTFLKD 141
            |.|.:.|.:|...|:.||..:..|:. ||...:|:   :||           |..|.|  .||.:
Human     5 SRQIVLLFSGFWGLAMGAFPSSVQIG-GLFIRNTD---QEY-----------TAFRLA--IFLHN 52

  Fly   142 YSFEQKNIHFDMMS-----LTPSPTAILSTLCKEFLRVNVSAILYMMNNEQFG-HSTASAQYFLQ 200
            .|.......|:::.     .|.:..|:.:..|.::.| .|.||        || :...|......
Human    53 TSPNASEAPFNLVPHVDNIETANSFAVTNAFCSQYSR-GVFAI--------FGLYDKRSVHTLTS 108

  Fly   201 LAGYLGIPVISWNADNSGLERRASQSTLQLQLAPSIEHQSAAMLSILERYKWHQFSVVTSQIAGH 265
            ....|.|.:|:.:....|      :|...|||.||:.   .|:||:|:.|:|:.|..:.....|:
Human   109 FCSALHISLITPSFPTEG------ESQFVLQLRPSLR---GALLSLLDHYEWNCFVFLYDTDRGY 164

  Fly   266 DDFVQAVRERVAEMQEHFKFTILNSIVVTRTSD------LMELVNSEARVMLLYATQTEAITILR 324
             ..:||:.|:..:...|     :::|.|...:|      |.||   :.|....:....|...:..
Human   165 -SILQAIMEKAGQNGWH-----VSAICVENFNDVSYRQLLEEL---DRRQEKKFVIDCEIERLQN 220

  Fly   325 AAEEMKLTGEN---YVWVVS----QSVIEKKDAHSQFPV-GMLGVHFDTSSAALMNEISNAIKIY 381
            ..|::...|::   |.::::    :.:..::..|....| |...|.|:|.....:.:....:...
Human   221 ILEQIVSVGKHVKGYHYIIANLGFKDISLERFIHGGANVTGFQLVDFNTPMVIKLMDRWKKLDQR 285

  Fly   382 SY-GVEAYLTDP--------------ANRDRRLTTQSLSCEDEGR---------GRWDNGEIFFK 422
            .| |.|   |.|              |...|.|..|.:.....|.         ..|..|....:
Human   286 EYPGSE---TPPKYTSALTYDGVLVMAETFRSLRRQKIDISRRGNAGDCLANPAAPWGQGIDMER 347

  Fly   423 YLRNVSIEGDLNKPNIEFTADGDLRSAELKIMNLRPSANNKNLVWEEIGVWKSWETQKLDIRDIA 487
            .|:.|.|:|...  |::|...|...:..:.:..|:.:...|      :|.|...:...| |:|:.
Human   348 TLKQVRIQGLTG--NVQFDHYGRRVNYTMDVFELKSTGPRK------VGYWNDMDKLVL-IQDVP 403

  Fly   488 WPGNSHAPPQGVPEKFHLKITFLEEAPYINLSPADPVSGKCLMDRGVLCRVAADHEMAADIDVGQ 552
            ..||..|    ..|...:.:|.:.|:||:                    ....:|||
Human   404 TLGNDTA----AIENRTVVVTTIMESPYV--------------------MYKKNHEM-------- 436

  Fly   553 AHRNESFYQCCSGFCIDLLEKFAEELGFTYELVRVEDGKWGT--LENGKWNGLIADLVNRKTDMV 615
            ...|:.:    .|:|:||..:.|:.:|..|::..|.|||:|.  .:...|||::.:||..|.::.
Human   437 FEGNDKY----EGYCVDLASEIAKHIGIKYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIA 497

  Fly   616 LTSLMINTEREAVVDFSEPFMETGIAIVVAK----RTGIISPTAFLEPFDTASWMLVGIVAIQAA 676
            :..|.|...||.|:|||:|||..||:|::.|    :.|:.|   ||:|.....||.: :.|....
Human   498 IAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFS---FLDPLAYEIWMCI-VFAYIGV 558

  Fly   677 TFMIFL------FEWLSPSGYDMKLYLQNTNVTPYRFSLFRTYWLVWAVLFQAAVHVDSPRGFTS 735
            :.::||      :||.:....|.|  ...::..|..|.:|.:.|.......|....: |||..:.
Human   559 SVVLFLVSRFSPYEWHTEEPEDGK--EGPSDQPPNEFGIFNSLWFSLGAFMQQGCDI-SPRSLSG 620

  Fly   736 RFMTNVWALFAVVFLAIYTANLAAFMITREEFHEFSGLNDSRLVHP------FSHKPSFKFGTIP 794
            |.:..||..|.::.::.||||||||            |...|:|.|      .:.:....:||:.
Human   621 RIVGGVWWFFTLIIISSYTANLAAF------------LTVERMVSPIESAEDLAKQTEIAYGTLD 673

  Fly   795 YSHTDSTIHK----YFNVMHNYMRQ-----YNKTSVADGVAAV--LNGNLDSFIYDGTVLDYLVA 848
            ...|.....:    .:..|..|||.     :.:|: |:|||.|  ..|.. :|:.:.|:.:| :.
Human   674 SGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTT-AEGVARVRKSKGKF-AFLLESTMNEY-IE 735

  Fly   849 QDEDCRLMTVGSWYAMTGYGLAFSRNSKYVQMFNKRLLEFRANGDLERLRRYWM--TGTCRP--- 908
            |.:.|..|.||......|||:|..:.|......|..:|:....|.|::|:..|.  .|.|.|
Human   736 QRKPCDTMKVGGNLDSKGYGVATPKGSSLRTPVNLAVLKLSEAGVLDKLKNKWWYDKGECGPKDS 800

  Fly   909 GKQEHKSSDPLALEQFLSAFLLLMAGILLAALLLLLEHVYFKYIRKRLAKKDGGHCCALISLSMG 973
            |.::..|:  |:|......|.:|:.|:.||.|:.|:|   |.|..:..||:        :.|:..
Human   801 GSKDKTSA--LSLSNVAGVFYILVGGLGLAMLVALIE---FCYKSRAEAKR--------MKLTFS 852

  Fly   974 KS------LTFRGAVFEATEIL 989
            ::      |:..|:|.|...:|
Human   853 EAIRNKARLSITGSVGENGRVL 874

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.