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Protein Alignment Nmdar2 and GRIA3

DIOPT Version :9

Sequence 1:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster
Sequence 2:	NP_000819.4	Gene:	GRIA3 / 2892	HGNCID:	4573	Length:	894	Species:	Homo sapiens

Alignment Length:	900	Identity:	207/900 - (23%)
Similarity:	349/900 - (38%)	Gaps:	222/900 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 NIHFDMMSLTPSPTAILSTLCKEFLRVNVSAILYMMNNEQFG-HSTASAQYFLQLAGYLGIPVI- 210
            |.|.|.:..:.| .::.:..|.:|.| .|.||        || :...|........|.|....:
Human    72 NYHVDHLDSSNS-FSVTNAFCSQFSR-GVYAI--------FGFYDQMSMNTLTSFCGALHTSFVT 126

  Fly   211 -SWNADNSGLERRASQSTLQLQLAPSIEHQSAAMLSILERYKWHQ----------FSV------- 257
             |:..|        :.....:|:.|:::   .|:||:|..|||.:          ||:
Human   127 PSFPTD--------ADVQFVIQMRPALK---GAILSLLGHYKWEKFVYLYDTERGFSILQAIMEA 180

  Fly   258 -------VTSQIAGHDDFVQAVRERVAEMQEHFKFTILNSIVVTRTSDLMELVNSEARVMLL--- 312
                   ||::..|:...||..|..:.||....:...|....|.|.:.::|      :|::|
Human   181 AVQNNWQVTARSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILE------QVVILGKH 239

  Fly   313 -----YATQTEAITILRAAEEM----KLTG---------------ENYVWVVSQSVIEKKDAHSQ 353
                 |.......|.:.....|    .:||               :.:|.:..:...|.|:|..:
Human   240 SRGYHYMLANLGFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKNAPLK 304

  Fly   354 FPVGMLGVHFDTSSAALMNEISNAIKIYSYGVEAYLTDPANRDRRLTTQSLSCEDEGRG------ 412
            :            ::||.::   ||.:.:   ||:        |.|..|.:.....|..
Human   305 Y------------TSALTHD---AILVIA---EAF--------RYLRRQRVDVSRRGSAGDCLAN 343

  Fly   413 ---RWDNGEIFFKYLRNVSIEGDLNKPNIEFTADGDLRSAELKIMNLRPSANNKNLVWEEIGVWK 474
               .|..|....:.|:.|.::|...  ||:|...|...:..:.:..::.|.:.|      .|.|.
Human   344 PAVPWSQGIDIERALKMVQVQGMTG--NIQFDTYGRRTNYTIDVYEMKVSGSRK------AGYWN 400

  Fly   475 SWETQKLDIRDIAWPGNSHAPPQGVPEKFHLKITFLEEAPYINLSPADPVSGKCLMDRGVLCRVA 539
            .:|      |.:.:.....:......|...:.:|.:.|:||:                    ...
Human   401 EYE------RFVPFSDQQISNDSASSENRTIVVTTILESPYV--------------------MYK 439

  Fly   540 ADHEMAADIDVGQAHRNESFYQCCSGFCIDLLEKFAEELGFTYELVRVEDGKWGTL--ENGKWNG 602
            .:||        |...||.:    .|:|:||..:.|:.:...|:|..|.|||:|..  |...|||
Human   440 KNHE--------QLEGNERY----EGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIWNG 492

  Fly   603 LIADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGIAIVVAK----RTGIISPTAFLEPFDTA 663
            ::.:||..:.|:.:..|.|...||.|:|||:|||..||:|::.|    :.|:.|   ||:|....
Human   493 MVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFS---FLDPLAYE 554

  Fly   664 SWMLVGIVAIQAATFMIFLFEWLSPSGYDMKLYLQNTNV----------TPYRFSLFRTYWLVWA 718
            .||.: :.|....:.::||....||  |:.  :|::.|.          .|..|.:|.:.|....
Human   555 IWMCI-VFAYIGVSVVLFLVSRFSP--YEW--HLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLG 614

  Fly   719 VLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAAFMITREEFHEFSGLNDSRLVHP-- 781
            ...|....: |||..:.|.:..||..|.::.::.||||||||            |...|:|.|
Human   615 AFMQQGCDI-SPRSLSGRIVGGVWWFFTLIIISSYTANLAAF------------LTVERMVSPIE 666

  Fly   782 ----FSHKPSFKFGTIPYSHTDSTIHK----YFNVMHNYMRQ-----YNKTSVADGVAAV--LNG 831
                .:.:....:||:....|.....:    .:..|.:||:.     :.||: |||||.|  ..|
Human   667 SAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTT-ADGVARVRKSKG 730

  Fly   832 NLDSFIYDGTVLDYLVAQDEDCRLMTVGSWYAMTGYGLAFSRNSKYVQMFNKRLLEFRANGDLER 896
            .. :|:.:.|:.:| :.|.:.|..|.||......|||:|..:.|......|..:|:....|.|::
Human   731 KF-AFLLESTMNEY-IEQRKPCDTMKVGGNLDSKGYGVATPKGSALRNAVNLAVLKLNEQGLLDK 793

  Fly   897 LRRYWM--TGTCRPGKQEHK-SSDPLALEQFLSAFLLLMAGILLAALLLLLEHVY 948
            |:..|.  .|.|..|..:.| .:..|:|......|.:|:.|:.||.::.|:|..|
Human   794 LKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCY 848

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.