Protein Alignment Nmdar2 and GRIA1

DIOPT Version :10

• Sequence 1: NP_001014714.1
• Gene: Nmdar2 / 31107
• FlyBaseID: FBgn0053513
• Length: 1083
• Species: Drosophila melanogaster
• Sequence 2: NP_001244950.1
• Gene: GRIA1 / 2890
• HGNCID: 4571
• Length: 916
• Species: Homo sapiens
• Alignment Length: 922
• Identity: 206/922 - (22%)
• Similarity: 354/922 - (38%)
• Gaps: 204/922 - (22%)

  Fly   138 FLKDYSFEQKNIHFDMMSLTPSPTAI--------------LSTLCKEFLRVNVSAILYMMNNEQF 188
            |....|.|.....|.:..||..|..:              ....|.:|.: .|.||        |
Human    41 FPNQQSQEHAAFRFALSQLTEPPKLLPQIDIVNISDSFEMTYRFCSQFSK-GVYAI--------F 96

  Fly   189 G-HSTASAQYFLQLAGYLGIPVI--SWNADNSGLERRASQSTLQLQLAPSIEHQSAAMLSILERY 250
            | :...:........|.|.:..|  |:..|.|        :...|||.|.::.   |::||::.|
Human    97 GFYERRTVNMLTSFCGALHVCFITPSFPVDTS--------NQFVLQLRPELQD---ALISIIDHY 150

  Fly   251 KWHQFSVVTSQIAGHDDFVQAVRERVAEMQEHFKFTILNSIVVTRTSDLM---ELVNSEARVMLL 312
            ||.:|..:.....|. ..:|.|.:..||  ::::.|.:|.:..|.....|   :|...:.|::::
Human   151 KWQKFVYIYDADRGL-SVLQKVLDTAAE--KNWQVTAVNILTTTEEGYRMLFQDLEKKKERLVVV 212

  Fly   313 YATQTEAITILRAAEEMKLTGENYVWVVSQ------SVIEKKDAHSQFPVGMLGVHFDTSSAALM 371
            .........||....:::..|..|.::::.      .:.:.|::.:......|..:.||..|.:|
Human   213 DCESERLNAILGQIIKLEKNGIGYHYILANLGFMDIDLNKFKESGANVTGFQLVNYTDTIPAKIM 277

  Fly   372 NEISNA-----------------------IKIYSYGVEAYLTDPANRDRRLTTQSLSCEDEGRG- 412
            .:..|:                       :|:.:   ||:        :.|..|.:.....|..
Human   278 QQWKNSDARDHTRVDWKRPKYTSALTYDGVKVMA---EAF--------QSLRRQRIDISRRGNAG 331

  Fly   413 --------RWDNGEIFFKYLRNVSIEGDLNKPNIEFTADGDLRSAELKIMNLRPSANNKNLVWEE 469
                    .|..|....:.|:.|..||...  |::|...|...:..|.::.::.....|
Human   332 DCLANPAVPWGQGIDIQRALQQVRFEGLTG--NVQFNEKGRRTNYTLHVIEMKHDGIRK------ 388

  Fly   470 IGVWKSWETQKLDIRDIAWPGNSHAPPQG----VPEKFHLKITFLEEAPYINLSPADPVSGKCLM 530
            ||.|.  |..|.      .|..:.|...|    |..:.::..|.||: ||:.|..
Human   389 IGYWN--EDDKF------VPAATDAQAGGDNSSVQNRTYIVTTILED-PYVMLKK---------- 434

  Fly   531 DRGVLCRVAADHEMAADIDVGQAHRNESFYQCCSGFCIDLLEKFAEELGFTYELVRVEDGKWGTL 595
                              :..|...|:.:    .|:|::|..:.|:.:|::|.|..|.|||:|..
Human   435 ------------------NANQFEGNDRY----EGYCVELAAEIAKHVGYSYRLEIVSDGKYGAR 477

  Fly   596 --ENGKWNGLIADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGIAIVVAK----RTGIISPT 654
              :...|||::.:||..:.|:.:..|.|...||.|:|||:|||..||:|::.|    :.|:.|
Human   478 DPDTKAWNGMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFS-- 540

  Fly   655 AFLEPFDTASWMLVGIVAIQAATFMIFL------FEWLS---PSGYDMKLYLQNTNVTPYRFSLF 710
             ||:|.....||.: :.|....:.::||      :||.|   ..|.|     |.|:.....|.:|
Human   541 -FLDPLAYEIWMCI-VFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRD-----QTTSDQSNEFGIF 598

  Fly   711 RTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAAFMITREEFHEFSGLND 775
            .:.|.......|....: |||..:.|.:..||..|.::.::.||||||||            |..
Human   599 NSLWFSLGAFMQQGCDI-SPRSLSGRIVGGVWWFFTLIIISSYTANLAAF------------LTV 650

  Fly   776 SRLVHP------FSHKPSFKFGTIPYSHTDSTIHK----YFNVMHNYMRQYNKT----SVADGVA 826
            .|:|.|      .:.:....:||:....|.....:    .|..|..||:....:    :..:|:.
Human   651 ERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMI 715

  Fly   827 AVLNG-NLDSFIYDGTVLDYLVAQDEDCRLMTVGSWYAMTGYGLAFSRNSKYVQMFNKRLLEFRA 890
            .|... ...:::.:.|:.:| :.|.:.|..|.||......|||:|..:.|......|..:|:...
Human   716 RVRKSKGKYAYLLESTMNEY-IEQRKPCDTMKVGGNLDSKGYGIATPKGSALRNPVNLAVLKLNE 779

  Fly   891 NGDLERLRRYWM--TGTCRPGKQEHK-SSDPLALEQFLSAFLLLMAGILLAALLLLLEHVYFKYI 952
            .|.|::|:..|.  .|.|..|..:.| .:..|:|......|.:|:.|:.||.|:.|:|   |.|.
Human   780 QGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIE---FCYK 841

  Fly   953 RKRLAKKDGGHC 964
            .:..:|:..|.|
Human   842 SRSESKRMKGFC 853

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..485	CDD:380601	75/404 (19%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	110/437 (25%)
GRIA1	NP_001244950.1	PBP1_iGluR_AMPA_GluR1	36..402	CDD:380613	76/410 (19%)
		PBP2_iGluR_AMPA_GluR1	416..797	CDD:270447	109/436 (25%)