DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nmdar2 and Ir41a

DIOPT Version :9

Sequence 1:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster
Sequence 2:	NP_995744.4	Gene:	Ir41a / 2768714	FlyBaseID:	FBgn0040849	Length:	648	Species:	Drosophila melanogaster

Alignment Length:	487	Identity:	96/487 - (19%)
Similarity:	164/487 - (33%)	Gaps:	143/487 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   542 HEMAADI-DVGQAHRNESFYQCCSGFCIDLLEKFAEELGFTYELVRVEDGKWGTL-ENGKWNGLI 604
            |.|:.:. |:|.:..::.......|....::..|.|:...|.::.......||.: .|...:|.:
  Fly   228 HNMSTNAQDMGVSGESDFKNVYIDGTETRIVLNFCEQFNCTIQIDSSAANDWGKVYPNMSGDGAL 292

  Fly   605 ADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGIAIVVAKRTGIISPTAFLEPFDTASWMLVG 669
            ..|:|||.|:.:.::....|....:|.|...:.:||..:|.....:.|....||||....|..:.
  Fly   293 GMLINRKADICIGAMYSWYEDYTYLDLSMYLVRSGITCLVPAPLRLTSWYLPLEPFKETLWAAIL 357

  Fly   670 IVAIQAATFMIFLFEWLSPSGYDMKLYLQNTNVTP-YR--------------FSLF-------RT 712
            :.....||.::..::      .:..||     |.| ||              |.||       :.
  Fly   358 LCLCAEATGLVLAYK------SEQALY-----VLPGYREGWWTCTSFGVCTTFKLFISQSGNSKA 411

  Fly   713 YWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAAFMITREEFHEFS------ 771
            |.|...||..|..       .....:|:::.......|.|.:.:.||..:||..||...
  Fly   412 YSLTVRVLLFACF-------LNDLIITSIYGGGLASILTIPSMDEAADTVTRLRFHRLQWAANSE 469

  Fly   772 ------GLNDSRLV-------HPFSH------------KPSFKFGTIPYSHTDSTIHKYFNVMHN 811
                  ..:|..||       |.:|.            :..|....:|:.|.         .:.|
  Fly   470 AWVSAIRASDEALVKDILYNFHIYSDDELLRLAQDQHMRIGFTVERLPFGHF---------AIGN 525

  Fly   812 YMRQYNKTSVADGVAAVLNGNLDSFIYDGTVLDYLVAQDEDC-----------------RLMT-V 858
            |:          |..|:               |.||...:|.                 :|.| :
  Fly   526 YL----------GPQAI---------------DQLVIMKDDIYFQYTVAFVPRLWPLLDKLNTLI 565

  Fly   859 GSWYAMTGYGLAFSRNSKYVQMFNKRLLEFRANGDLERLRRYWMTGTCRPGKQEHKSSDPLALEQ 923
            .||:: :|:       .||   :..|::....|..:::..:..||||...|..      ||.:..
  Fly   566 YSWHS-SGF-------DKY---WEYRVVADNLNLKIQQQVQETMTGTKDIGPV------PLGMSN 613

  Fly   924 FLSAFLLLMAGILLAALLLLLEHVYFKYIRKR 955
            |....::.:.|..:|.|..||| :...||.|:
  Fly   614 FAGFIIVWILGSAIATLTFLLE-LSLTYILKQ 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	83/438 (19%)
		Lig_chan	665..928	CDD:278489	59/333 (18%)
Ir41a	NP_995744.4	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45463022
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840