DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar2 and Grin2d

DIOPT Version :9

Sequence 1:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster
Sequence 2:	XP_038951440.1	Gene:	Grin2d / 24412	RGDID:	2740	Length:	1334	Species:	Rattus norvegicus

Alignment Length:	993	Identity:	293/993 - (29%)
Similarity:	456/993 - (45%)	Gaps:	177/993 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 PSGPISLLLLTVLTLLILDTRSCQGLRLTNGGGSLSKGAAANKEQLNIGLIAPHTNFGKREYLRS 120
            |.||..:|||..|...........|.....||    .|.|   ..||:.|:     |....|...
  Rat    10 PRGPAKMLLLLALACASPFPEEVPGPGAVGGG----TGGA---RPLNVALV-----FSGPAYAAE 62

  Fly   121 ---INNAVTGLTKTRGAKLTFLKDYSFEQKNIHFDMMSLTP--------SPTAILSTLCKEFLRV 174
               :..||....::.|                    :.:.|        .|.:::..||.....:
  Rat    63 AARLGPAVAAAVRSPG--------------------LDVRPVALVLNGSDPRSLVLQLCDLLSGL 107

  Fly   175 NVSAILYMMNNEQFGHSTASAQYFLQLAGYLGIPVISWNADNSGLERRASQSTLQLQLAPSIEHQ 239
            .|..:::    |....:.|.|.....|:....:|:::.:...:.:.....:.:..|||..|.|.|
  Rat   108 RVHGVVF----EDDSRAPAVAPILDFLSAQTSLPIVAVHGGAALVLTPKEKGSTFLQLGSSTEQQ 168

  Fly   240 SAAMLSILERYKWHQFSVVTSQIAGHDDFVQAVRERVAEMQEHFKFTILNSIVVTRTSDLM---- 300
            ...:..:||.|.|..|..||::..||..|                   |:.|.|.....|:
  Rat   169 LQVIFEVLEEYDWTSFVAVTTRAPGHRAF-------------------LSYIEVLTDGSLVGWEH 214

  Fly   301 -----------------ELVNSEARVMLLYATQTEAITILRAAEEMKLTGENYVW---------- 338
                             :|.:..|::.||:..:.||..:.|||||..|||..|||
  Rat   215 RGALTLDPGAGEAVLGAQLRSVSAQIRLLFCAREEAEPVFRAAEEAGLTGPGYVWFMVGPQLAGG 279

  Fly   339 ----VVSQSVIEKKDAHSQFPVGMLGVHFDTSSAALMNEISNAIKIYSYGVEAYLTD-----PAN 394
                |..:.::  ....|..|.|:..|........|...::..:.:.:.|.:|.|.|     ...
  Rat   280 GGSGVPGEPLL--LPGGSPLPAGLFAVRSAGWRDDLARRVAAGVAVVARGAQALLRDYGFLPELG 342

  Fly   395 RDRRLTTQSLSCEDEGRGRWDNGEIFFKYLRNVSIEGDLNKPNIEFTADGDLRSAELKIMNLRPS 459
            .|.|  ||:         |...||...:|..|::.:   |: :..|..||.|.:..|.:::|
  Rat   343 HDCR--TQN---------RTHRGESLHRYFMNITWD---NR-DYSFNEDGFLVNPSLVVISL--- 389

  Fly   460 ANNKNLVWEEIGVWKSWETQKLDIRDIAWP--GNSHAPPQGVPEKFHLKITFLEEAPYINLSPAD 522
              .::..||.:|   |||.|.|.::...|.  |....|   |.:..||.:..|||.|::.:.|||
  Rat   390 --TRDRTWEVVG---SWEQQTLRLKYPLWSRYGRFLQP---VDDTQHLTVATLEERPFVIVEPAD 446

  Fly   523 PVSGKCLMDRGVLCRVAADHEMAADIDVGQAHRNESFYQCCSGFCIDLLEKFAEELGFTYELVRV 587
            |:||.|:.| .|.||...:...:...|   |.|.|.  :||.|||||:|::.|..:||:|:|..|
  Rat   447 PISGTCIRD-SVPCRSQLNRTHSPPPD---APRPEK--RCCKGFCIDILKRLAHTIGFSYDLYLV 505

  Fly   588 EDGKWGTLENGKWNGLIADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGIAIVVAKRTGIIS 652
            .:||.|...:|.|||:|.::..::.||.:.||.||.||..:||||.||:||||:::||:..|.:|
  Rat   506 TNGKHGKKIDGVWNGMIGEVFYQRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVS 570

  Fly   653 PTAFL-----------EPFDTASWMLVGIVAIQAATFMIFLFEWLSPSGYDMKLYLQNTNVTP-- 704
            |:|||           ||:..|.|:::.::.:......:|:||:|||.||:..|   .|...|
  Rat   571 PSAFLAFAWLTPPMSPEPYSPAVWVMMFVMCLTVVAVTVFIFEYLSPVGYNRSL---ATGKRPGG 632

  Fly   705 YRFSLFRTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAAFMITREEFHE 769
            ..|::.::.||:||::|..:|.|::|||.||:.|..|||.|||:|||.||||||||||..|....
  Rat   633 STFTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYVDT 697

  Fly   770 FSGLNDSRLVHPFSHKPSFKFGTIPYSHTDSTIHKYFNVMHNYMRQYNKTSVADGVAAVLNGNLD 834
            .|||:|.:...|....|..||||:|...|:..|...:..||:||.:||:..|.:.:..:..|.||
  Rat   698 VSGLSDRKFQRPQEQYPPLKFGTVPNGSTEKNIRSNYPDMHSYMVRYNQPRVEEALTQLKAGKLD 762

  Fly   835 SFIYDGTVLDYLVAQDEDCRLMTVGSW--YAMTGYGLAFSRNSKYVQMFNKRLLEFRANGDLERL 897
            :||||..||:|:..:||.|:|:|:||.  :|.||||:|..:.|::.:..:..||:|..:.::|.|
  Rat   763 AFIYDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEML 827

  Fly   898 RRYWMTGTCRPGKQEHKSSDPLALEQFLSAFLLLMAGILLAALLLLLEHVYFKYIRKRLAKKDGG 962
            .|.|::|.|...|.|..|| .|.::.....|.:|:..:.|:.|:...||:.:..:|
  Rat   828 ERLWLSGICHNDKIEVMSS-KLDIDNMAGVFYMLLVAMGLSLLVFAWEHLVYWRLR--------- 882

  Fly   963 HCCA-------LISLSMG 973
            ||..       |::.|.|
  Rat   883 HCLGPTHRMDFLLAFSRG 900

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	90/443 (20%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	171/420 (41%)
		Lig_chan	665..928	CDD:278489	104/266 (39%)
Grin2d	XP_038951440.1	PBP1_iGluR_NMDA_NR2	46..410	CDD:380601	89/436 (20%)
		PBP2_iGluR_NMDA_Nr2	427..838	CDD:270436	171/419 (41%)
		PHA03307	<1125..>1312	CDD:223039
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350167
Domainoid	1	1.000	214	1.000	Domainoid score	I2649
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H648
Inparanoid	1	1.050	456	1.000	Inparanoid score	I1530
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D279143at33208
OrthoFinder	1	1.000	-	-		FOG0000775
OrthoInspector	1	1.000	-	-		otm45107
orthoMCL	1	0.900	-	-		OOG6_102799
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.760