Protein Alignment Nmdar2 and Grin2d

DIOPT Version :10

• Sequence 1: NP_001014714.1
• Gene: Nmdar2 / 31107
• FlyBaseID: FBgn0053513
• Length: 1083
• Species: Drosophila melanogaster
• Sequence 2: XP_063136781.1
• Gene: Grin2d / 24412
• RGDID: 2740
• Length: 1356
• Species: Rattus norvegicus
• Alignment Length: 982
• Identity: 293/982 - (29%)
• Similarity: 456/982 - (46%)
• Gaps: 166/982 - (16%)

  Fly    56 PSGPISLLLLTVLTLLILDTRSCQGLRLTNGGGSLSKGAAANKEQLNIGLIAPHTNFGKREYLRS 120
            |.||..:|||..|...........|.....||    .|.|   ..||:.|:     |....|...
  Rat    10 PRGPAKMLLLLALACASPFPEEVPGPGAVGGG----TGGA---RPLNVALV-----FSGPAYAAE 62

  Fly   121 ---INNAVTGLTKTRGAKLTFLKDYSFEQKNIHFDMMSLTP--------SPTAILSTLCKEFLRV 174
               :..||....::.|                    :.:.|        .|.:::..||.....:
  Rat    63 AARLGPAVAAAVRSPG--------------------LDVRPVALVLNGSDPRSLVLQLCDLLSGL 107

  Fly   175 NVSAILYMMNNEQFGHSTASAQYFLQLAGYLGIPVISWNADNSGLERRASQSTLQLQLAPSIEHQ 239
            .|..:::    |....:.|.|.....|:....:|:::.:...:.:.....:.:..|||..|.|.|
  Rat   108 RVHGVVF----EDDSRAPAVAPILDFLSAQTSLPIVAVHGGAALVLTPKEKGSTFLQLGSSTEQQ 168

  Fly   240 SAAMLSILERYKWHQFSVVTSQIAGHDDFVQAVRERVAEMQEHFKFTILNSIVVTRTSDLM---- 300
            ...:..:||.|.|..|..||::..||..|                   |:.|.|.....|:
  Rat   169 LQVIFEVLEEYDWTSFVAVTTRAPGHRAF-------------------LSYIEVLTDGSLVGWEH 214

  Fly   301 -----------------ELVNSEARVMLLYATQTEAITILRAAEEMKLTGENYVW---------- 338
                             :|.:..|::.||:..:.||..:.|||||..|||..|||
  Rat   215 RGALTLDPGAGEAVLGAQLRSVSAQIRLLFCAREEAEPVFRAAEEAGLTGPGYVWFMVGPQLAGG 279

  Fly   339 ----VVSQSVIEKKDAHSQFPVGMLGVHFDTSSAALMNEISNAIKIYSYGVEAYLTD-----PAN 394
                |..:.::  ....|..|.|:..|........|...::..:.:.:.|.:|.|.|     ...
  Rat   280 GGSGVPGEPLL--LPGGSPLPAGLFAVRSAGWRDDLARRVAAGVAVVARGAQALLRDYGFLPELG 342

  Fly   395 RDRRLTTQSLSCEDEGRGRWDNGEIFFKYLRNVSIEGDLNKPNIEFTADGDLRSAELKIMNLRPS 459
            .|.|  ||:         |...||...:|..|::.:   |: :..|..||.|.:..|.:::|
  Rat   343 HDCR--TQN---------RTHRGESLHRYFMNITWD---NR-DYSFNEDGFLVNPSLVVISL--- 389

  Fly   460 ANNKNLVWEEIGVWKSWETQKLDIRDIAWP--GNSHAPPQGVPEKFHLKITFLEEAPYINLSPAD 522
              .::..||.:|   |||.|.|.::...|.  |....|   |.:..||.:..|||.|::.:.|||
  Rat   390 --TRDRTWEVVG---SWEQQTLRLKYPLWSRYGRFLQP---VDDTQHLTVATLEERPFVIVEPAD 446

  Fly   523 PVSGKCLMDRGVLCRVAADHEMAADIDVGQAHRNESFYQCCSGFCIDLLEKFAEELGFTYELVRV 587
            |:||.|:.| .|.||...:...:...|   |.|.|.  :||.|||||:|::.|..:||:|:|..|
  Rat   447 PISGTCIRD-SVPCRSQLNRTHSPPPD---APRPEK--RCCKGFCIDILKRLAHTIGFSYDLYLV 505

  Fly   588 EDGKWGTLENGKWNGLIADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGIAIVVAKRTGIIS 652
            .:||.|...:|.|||:|.::..::.||.:.||.||.||..:||||.||:||||:::||:..|.:|
  Rat   506 TNGKHGKKIDGVWNGMIGEVFYQRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVS 570

  Fly   653 PTAFLEPFDTASWMLVGIVAIQAATFMIFLFEWLSPSGYDMKLYLQNTNVTP--YRFSLFRTYWL 715
            |:|||||:..|.|:::.::.:......:|:||:|||.||:..|   .|...|  ..|::.::.||
  Rat   571 PSAFLEPYSPAVWVMMFVMCLTVVAVTVFIFEYLSPVGYNRSL---ATGKRPGGSTFTIGKSIWL 632

  Fly   716 VWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAAFMITREEFHEFSGLNDSRLVH 780
            :||::|..:|.|::|||.||:.|..|||.|||:|||.||||||||||..|.....|||:|.:...
  Rat   633 LWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQR 697

  Fly   781 PFSHKPSFKFGTIPYSHTDSTIHKYFNVMHNYMRQYNKTSVADGVAAVLNGNLDSFIYDGTVLDY 845
            |....|..||||:|...|:..|...:..||:||.:||:..|.:.:..:..|.||:||||..||:|
  Rat   698 PQEQYPPLKFGTVPNGSTEKNIRSNYPDMHSYMVRYNQPRVEEALTQLKAGKLDAFIYDAAVLNY 762

  Fly   846 LVAQDEDCRLMTVGSW--YAMTGYGLAFSRNSKYVQMFNKRLLEFRANGDLERLRRYWMTGTCRP 908
            :..:||.|:|:|:||.  :|.||||:|..:.|::.:..:..||:|..:.::|.|.|.|::|.|..
  Rat   763 MARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWLSGICHN 827

  Fly   909 GKQEHKSSDPLALEQFLSAFLLLMAGILLAALLLLLEHVYFKYIRKRLAKKDGGHCCA------- 966
            .|.|..|| .|.::.....|.:|:..:.|:.|:...||:.:..:|         ||..
  Rat   828 DKIEVMSS-KLDIDNMAGVFYMLLVAMGLSLLVFAWEHLVYWRLR---------HCLGPTHRMDF 882

  Fly   967 LISLSMG 973
            |::.|.|
  Rat   883 LLAFSRG 889

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..485	CDD:380601	89/436 (20%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	171/409 (42%)
Grin2d	XP_063136781.1	None