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Protein Alignment Nmdar2 and Grin2b

DIOPT Version :9

Sequence 1:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster
Sequence 2:	NP_036706.1	Gene:	Grin2b / 24410	RGDID:	2738	Length:	1482	Species:	Rattus norvegicus

Alignment Length:	1034	Identity:	305/1034 - (29%)
Similarity:	489/1034 - (47%)	Gaps:	183/1034 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 LKDYSFEQKNIHFDMMSLTP----------SPTAILSTLCKEFLRVNVSAILYMMNNEQFGHSTA 193
            :|| :.|:.:.|.  :|:.|          .|.:|::.:|.......:..:::..:.:|    .|
  Rat    50 IKD-AHEKDDFHH--LSVVPRVELVAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQ----EA 107

  Fly   194 SAQYFLQLAGYLGIPVISWNADNSGLERRASQSTLQLQLAPSIEHQSAAMLSILERYKWHQFSVV 258
            .||....::.....|::..:..:|.:.....:|::..|..||||.|::.||:|:|.|.|:.||:|
  Rat   108 IAQILDFISAQTLTPILGIHGGSSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIV 172

  Fly   259 TSQIAGHDDFVQAVRERVAEMQEHFKFTILNSIVVTRTSDLM---------------ELVNSEAR 308
            |:...|:.|||..:|.           ||.||.|.....:::               :|...::.
  Rat   173 TTYFPGYQDFVNKIRS-----------TIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSP 226

  Fly   309 VMLLYATQTEAITILRAAEEMKLTGENYVWVVSQSVIEKKD-AHSQFPVGMLGVHFDTSSAALMN 372
            ::|||.|:.||..|...|..:.|||..|.|:|...|....| ..|:||.|::.|.:|.....|..
  Rat   227 IILLYCTKEEATYIFEVANSVGLTGYGYTWIVPSLVAGDTDTVPSEFPTGLISVSYDEWDYGLPA 291

  Fly   373 EISNAIKIYSYGV------EAYLTDPANRDRRLTTQSLSCEDEGRGRWDNGEIFFKYLRNVSIEG 431
            .:.:.|.|.:...      .:::.:|.:          ||.:....|.....:..:||.||:.||
  Rat   292 RVRDGIAIITTAASDMLSEHSFIPEPKS----------SCYNTHEKRIYQSNMLNRYLINVTFEG 346

  Fly   432 DLNKPNIEFTADGDLRSAELKIMNLRPSANNKNLVWEEIGVWKSWETQKLDIRDIAWPGNSHAPP 496
                .|:.|:.||.....:|.|:.|     ||...||.:|.||.   :.|.::...||  ...|.
  Rat   347 ----RNLSFSEDGYQMHPKLVIILL-----NKERKWERVGKWKD---KSLQMKYYVWP--RMCPE 397

  Fly   497 QGVPEKFHLKITFLEEAPYINLSPADPVSGKCLMDRGVLCRVAADHEMAADIDVGQAHRNESFYQ 561
            ....|..||.|..|||||::.:...||:||.| |...|.|:.....|...|.:.|...:
  Rat   398 TEEQEDDHLSIVTLEEAPFVIVESVDPLSGTC-MRNTVPCQKRIISENKTDEEPGYIKK------ 455

  Fly   562 CCSGFCIDLLEKFAEELGFTYELVRVEDGKWGTLENGKWNGLIADLVNRKTDMVLTSLMINTERE 626
            ||.|||||:|:|.::.:.|||:|..|.:||.|...||.|||:|.::|.::..|.:.||.||.||.
  Rat   456 CCKGFCIDILKKISKSVKFTYDLYLVTNGKHGKKINGTWNGMIGEVVMKRAYMAVGSLTINEERS 520

  Fly   627 AVVDFSEPFMETGIAIVVAKRTGIISPTAFLEPFDTASWMLVGIVAIQAATFMIFLFEWLSPSGY 691
            .|||||.||:||||:::|::..|.:||:||||||....|:::.::.:..:...:|:||:.||.||
  Rat   521 EVVDFSVPFIETGISVMVSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGY 585

  Fly   692 DMKLYLQNTNVTPYRFSLFRTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTAN 756
            :..|........| .|::.:..||:|.::|..:|.|.:|:|.||:.|.:|||.|||:|||.||||
  Rat   586 NRCLADGREPGGP-SFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTAN 649

  Fly   757 LAAFMITREEFHEFSGLNDSRLVHPFSHKPSFKFGTIPYSHTDSTIHKYFNVMHNYMRQYNKTSV 821
            ||||||..|...:.|||:|.:...|....|.|:|||:|...|:..|...:..||.||.::|:..|
  Rat   650 LAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNNYAEMHAYMGKFNQRGV 714

  Fly   822 ADGVAAVLNGNLDSFIYDGTVLDYLVAQDEDCRLMTVGSW--YAMTGYGLAFSRNSKYVQMFNKR 884
            .|.:.::..|.||:||||..||:|:..:||.|:|:|:||.  :|.||||:|..::|.:.:..:..
  Rat   715 DDALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLA 779

  Fly   885 LLEFRANGDLERLRRYWMTGTCRPGKQEHKSSDPLALEQFLSAFLLLMAGILLAALLLLLEHVYF 949
            :|:...:|::|.|...|:||.|...|.|..||. |.::.....|.:|.|.:.|:.:..:.||:::
  Rat   780 ILQLFGDGEMEELEALWLTGICHNEKNEVMSSQ-LDIDNMAGVFYMLGAAMALSLITFICEHLFY 843

  Fly   950 KYIRKRLAKKDGGHC----CA-----LISLSMGKSLTFRGAVFEA----------------TEIL 989
            ...|         ||    |:     :.|:|.|......|...|.                :.||
  Rat   844 WQFR---------HCFMGVCSGKPGMVFSISRGIYSCIHGVAIEERQSVMNSPTATMNNTHSNIL 899

  Fly   990 K-----------------------------------KHR-------C---NDPICDTHLWKVKHE 1009
            :                                   :||       |   |:|.|:.:|:.
  Rat   900 RLLRTAKNMANLSGVNGSPQSALDFIRRESSVYDISEHRRSFTHSDCKSYNNPPCEENLFS---- 960

  Fly  1010 LDMSRLRVRQLEKVMDKHGIKAPQLRLASSSDLLNHHHLKERPPLLGNLSLAASAQDLY 1068
             |.    :.::|:...       .|:|..|:...:|:|...||..:|:.|   |...||
  Rat   961 -DY----ISEVERTFG-------NLQLKDSNVYQDHYHHHHRPHSIGSTS---SIDGLY 1004

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.