DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar2 and Grik5

DIOPT Version :9

Sequence 1:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster
Sequence 2:	XP_006228444.1	Gene:	Grik5 / 24407	RGDID:	2735	Length:	980	Species:	Rattus norvegicus

Alignment Length:	1049	Identity:	244/1049 - (23%)
Similarity:	408/1049 - (38%)	Gaps:	278/1049 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 PISLLLLTVLTLLILDTRSCQGLRLTNGGGSLSKGAAANKEQLNIGLIAPHTNFGKREYL----- 118
            |..||||.::...   ..|||.|      .||...|          ::...|..|:.|.|
  Rat     2 PAELLLLLIVAFA---NPSCQVL------SSLRMAA----------ILDDQTVCGRGERLALALA 47

  Fly   119 -RSINNAVTGLTKTRGAKLTFLKDYSFEQKNIHFDMMSL-TPSPTAILSTLCKEFLRVNVSAILY 181
             ..||..:....|.|                :..|:..| ..|......|:| :.|...|.::|.
  Rat    48 REQINGIIEVPAKAR----------------VEVDIFELQRDSQYETTDTMC-QILPKGVVSVLG 95

  Fly   182 MMNNEQFGHSTASAQYFLQLAGYLGIPVISWNADNSGLERRASQSTLQLQ--------LAPSIEH 238
            ..:      |.|||.....:.|...||.|          :...:.|.:||        |.||.|.
  Rat    96 PSS------SPASASTVSHICGEKEIPHI----------KVGPEETPRLQYLRFASVSLYPSNED 144

  Fly   239 QSAAMLSILERYKWHQFSVVTSQIAGHDDFVQAVRERVAEMQEHFK-FTILNSIVVTRTSD---- 298
            .|.|:..||:.:.:...|::.           |..|.:..::|..: |.|....:..|..|
  Rat   145 VSLAVSRILKSFNYPSASLIC-----------AKAECLLRLEELVRGFLISKETLSVRMLDDSRD 198

  Fly   299 ----LMELVNSEARVMLLYATQTEAITILRAAEEMKLTGENYVWVVSQSVIEKKDAHSQFPV--- 356
                |.|:.:.:...:::.|..:.:..:||.|.|:.:|...|.::::.         ..||:
  Rat   199 PTPLLKEIRDDKVSTIIIDANASISHLVLRKASELGMTSAFYKYILTT---------MDFPILHL 254

  Fly   357 --------GMLGVH-FDTS-----------------------------SAALMNEISNAIKIYSY 383
                    .:||.. |:||                             |||||   .:|:.:...
  Rat   255 DGIVEDSSNILGFSMFNTSHPFYPEFVRSLNMSWRENCEASTYPGPALSAALM---FDAVHVVVS 316

  Fly   384 GVEAYLTDPANRDRRLTTQSLSCEDEGRGRWDNGEIFFKYLRNVSIEGDLNKPNIEFTADGDLRS 448
            .|.     ..||.:.:..:.|:|  .....|.:|.....|||.|..:|...:  :||.:.|...:
  Rat   317 AVR-----ELNRSQEIGVKPLAC--TSANIWPHGTSLMNYLRMVEYDGLTGR--VEFNSKGQRTN 372

  Fly   449 AELKIMNLRPSANNKNLVWEEIGVWKSWET-----QKLDIRDIAWPGNSHAPPQGVPEKFHLKIT 508
            ..|:|:......:      .|||||.|..|     ..|||.          ..|.:..| .|.:|
  Rat   373 YTLRILEKSRQGH------REIGVWYSNRTLAMNATTLDIN----------LSQTLANK-TLVVT 420

  Fly   509 FLEEAPYINLSP-ADPVSGKCLMDRGVLCRVAADHEMAADIDVGQAHRNESFYQCCSGFCIDLLE 572
            .:.|.||:...| ...:||                             ||.|    .|||:|:|.
  Rat   421 TILENPYVMRRPNFQALSG-----------------------------NERF----EGFCVDMLR 452

  Fly   573 KFAEELGFTYELVRVEDGKWGTLE-NGKWNGLIADLVNR-KTDMVLTSLMINTEREAVVDFSEPF 635
            :.||.|.|.|.|..||||.:|..| ||.|.|::.:|:|| |.|:.:.:..|..|||.|:|||:||
  Rat   453 ELAELLRFRYRLRLVEDGLYGAPEPNGSWTGMVGELINRQKADLAVAAFTITAEREKVIDFSKPF 517

  Fly   636 METGIAIV----VAKRTGIISPTAFLEPFDTASWMLVGIVAIQAATFMIFL------FEWLSPSG 690
            |..||:|:    :.::.|..|   ||:||..|.|:.: ::|..|.:.::||      :||.:|.
  Rat   518 MTLGISILYRVHMGRKPGYFS---FLDPFSPAVWLFM-LLAYLAVSCVLFLAARLSPYEWYNPH- 577

  Fly   691 YDMKLYLQNTNVTPYRFSLFRTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTA 755
               .......::...:::|..:.|.......|....: .||..::|.::.||..|.::.::.|||
  Rat   578 ---PCLRARPHILENQYTLGNSLWFPVGGFMQQGSEI-MPRALSTRCVSGVWWAFTLIIISSYTA 638

  Fly   756 NLAAFMITREEFHEFSGLNDSRLVHPFSHKPSFKFGTIPYSHTDSTI-------HKYFNVMHNYM 813
            |||||:..:.........:|      .:.:.:.::|||   |..||:       ::.:..|.|||
  Rat   639 NLAAFLTVQRMEVPVESADD------LADQTNIEYGTI---HAGSTMTFFQNSRYQTYQRMWNYM 694

  Fly   814 RQYNKT----SVADGVAAVLNGNLDSFIYDGTVLDYLVAQDEDCRLMTVGSWYAMTGYGLAFSRN 874
            :....:    |..:|:|.|||... :|:.:.|:.:|  .:..:|.|..:|......|||:.....
  Rat   695 QSKQPSVFVKSTEEGIARVLNSRY-AFLLESTMNEY--HRRLNCNLTQIGGLLDTKGYGIGMPLG 756

  Fly   875 SKYVQMFNKRLLEFRANGDLERLRRYWMTGTCRPGKQEHKSSDPLALEQFLSAFLLLMAGILLAA 939
            |.:.......:|:.:.|..||.|:|.|..|...|.:::|::.. |.:|.....|::|:.|:::|.
  Rat   757 SPFRDEITLAILQLQENNRLEILKRKWWEGGRCPKEEDHRAKG-LGMENIGGIFVVLICGLIIAV 820

  Fly   940 LLLLLEHVYF---------------------------KYIRKRLAKKDGGHCCALISLSMGKSLT 977
            .:.::|.::.                           |..|.|..::.||...||:||...:.:.
  Rat   821 FVAVMEFIWSTRRSAESEEVSVCQEMLQELRHAVSCRKTSRSRRRRRPGGPSRALLSLRAVREMR 885

  Fly   978 F-RGAVFEA 985
            . .|.::.|
  Rat   886 LSNGKLYSA 894

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	92/460 (20%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	119/429 (28%)
		Lig_chan	665..928	CDD:278489	64/279 (23%)
Grik5	XP_006228444.1	PBP1_iGluR_Kainate_KA1_2	23..401	CDD:380616	92/458 (20%)
Grik5	XP_006228444.1	Periplasmic_Binding_Protein_Type_2	414..785	CDD:389745	118/425 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350183
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740