Protein Alignment Nmdar2 and Grin3a

DIOPT Version :9

• Sequence 1: NP_001014714.1
• Gene: Nmdar2 / 31107
• FlyBaseID: FBgn0053513
• Length: 1083
• Species: Drosophila melanogaster
• Sequence 2: NP_001263284.1
• Gene: Grin3a / 242443
• MGIID: 1933206
• Length: 1135
• Species: Mus musculus
• Alignment Length: 1013
• Identity: 267/1013 - (26%)
• Similarity: 450/1013 - (44%)
• Gaps: 154/1013 - (15%)

  Fly   160 PTAILSTLCKEFLRVNVSAILYMMNNEQFGHSTASAQYFLQLAGYLGIPVISWNADNSGLER--- 221
            |.:.|.::|...:...|||:|      .|..|.........::..|.|||:|       :.|
Mouse   177 PFSFLQSVCHTVVVQGVSALL------AFPQSQGEMMELDLVSSVLHIPVLS-------IVRHEF 228

  Fly   222 -RASQSTLQLQLA--PSIEHQSAAMLSILERYKWHQFSVVTSQIAGHDDFVQAVRERVAEMQEHF 283
             |.||:.|.|||:  .|:...:...:|||....|:.||::..|    :|:  .:.:.:...:.:.
Mouse   229 PRESQNPLHLQLSLENSLSSDADVTVSILTMNNWYNFSLLLCQ----EDW--NITDFLLLTENNS 287

  Fly   284 KFTILNSIVVT----RTSDL-------MELVNSEARVMLLYATQTEAI-TILRAAEEMKLTGENY 336
            ||.:.:.|.:|    .|.||       :|.:.:....|:::.....:| .|...:.:..|:..:.
Mouse   288 KFHLESIINITANLSSTKDLLSFLQVQLENIRNSTPTMVMFGCDMGSIRQIFEMSTQFGLSPPDL 352

  Fly   337 VWVV--SQSVIEKKDAHSQFPVGMLGVHFDTSSAALMNEISNAIKIYSYGV-EAYLTDPANRDRR 398
            .||:  ||:|.|.:.  ...|:|:: .|..|:.:.....:.:|:::.:..| .|.:..|   :..
Mouse   353 HWVLGDSQNVEELRT--EGLPLGLI-AHGKTTQSVFEYYVQDAMELVARAVATATMIQP---ELA 411

  Fly   399 LTTQSLSCEDEGRGRWDNGEIFFKYLRNVSIEGDLNKPNIEFTADGDLRSAELKIMNLRPSANN- 462
            |...:::|.|.......:|:...::|.|.:..|          ..|   |.::|...:..|.||
Mouse   412 LLPSTMNCMDVKTTNLTSGQYLSRFLANTTFRG----------LSG---SIKVKGSTIVSSENNF 463

  Fly   463 --KNLVWEEIG--VWK---SWETQKLDIRDIAWP--GNSHAPPQGVPEKFHLKITFLEEAPYINL 518
              .||.::.:|  :|.   ||:..::.:....||  ...|......|.|.||::..|.|.|::..
Mouse   464 FIWNLQYDPMGKPMWTRLGSWQGGRIVMDSGIWPEQAQRHKTHFHHPNKLHLRVVTLIEHPFVFT 528

  Fly   519 SPADPVSGKCLMDRGVLCRVAADHEMA-ADIDVGQAHRNE-----SFYQCCSGFCIDLLEKFAEE 577
            ...|. .|.|  ..|.||.....::.: .|......|.:.     .|.:||.|:||||||:.||:
Mouse   529 REVDD-EGLC--PAGQLCLDPMTNDSSILDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEQLAED 590

  Fly   578 LGFTYELVRVEDGKWGTLENGKWNGLIADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGIAI 642
            :.|.::|..|.|||:|..:||.|.||:.||::...:|.:||..|||.|..|:||:.||..|.:.|
Mouse   591 MNFDFDLYIVGDGKYGAWKNGHWTGLVGDLLSGTANMAVTSFSINTARSQVIDFTSPFFSTSLGI 655

  Fly   643 VVAKRTGIISPTAFLEPFDTASWMLVGI-VAIQAATFMIFLFEWLSPSGYDMKLYLQNTNVTPYR 706
            :|..|.......||:.|.....|:  || ||:......:.|:||.||.|...|  .:|.|..
Mouse   656 LVRTRDTAAPIGAFMWPLHWTMWL--GIFVALHITAIFLTLYEWKSPFGMTPK--GRNRNKV--- 713

  Fly   707 FSLFRTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAAFMITREEFHEFS 771
            ||......:.:|:||.....:..|:.:|.||:.|:||:|.:..|:.|||||||.|:..:.:.|.|
Mouse   714 FSFSSALNVCYALLFGRTAAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELS 778

  Fly   772 GLNDSRLVHPFSHKPSFKFGTIPYSHTDSTIHKYFNVMHNYMRQYNKTSVADGVAAVLNG--NLD 834
            |::|.:|.||   ...|:|||:..|..:..:.:.|..||.|||:||..:..|||..:.|.  .||
Mouse   779 GIHDPKLHHP---SQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNVPATPDGVQYLKNDPEKLD 840

  Fly   835 SFIYDGTVLDYLVAQDEDCRLMTVGSWYAMTGYGLAFSRNSKYVQMFNKRLLEFRANGDLERLRR 899
            :||.|..:|||.|:.|.||:|:|||..:|:.|||:....||......::.:.:::::|.::.|..
Mouse   841 AFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTSNISELISQYKSHGFMDVLHD 905

  Fly   900 YW-MTGTCRPGKQEHKSSDPL--ALEQFLSAFLLLMAGILLAALLLLLEHVYFKYIRKRLAKKD- 960
            .| ....|  ||:....::.|  .::.|...|:||..|..|:.|..:.||:.::.:..|:..|.
Mouse   906 KWYKVVPC--GKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVYRLLLPRIKNKSK 968

  Fly   961 ---GGHCCALISLSMGKSLTFRGAVFEATEILKKHRCNDPICDTH-------------------L 1003
               ..|.......::..|..........|:.::|.|.....|.|.                   :
Mouse   969 LQYWLHTSQRFHRALNTSFVEEKQPCSKTKRVEKSRWRRWTCKTEGDSELSLFPRSNMGPQQLMV 1033

  Fly  1004 WKVKH-------------ELDMSRL------------RVRQLEKVMDKHGIKAPQLRLASSSDLL 1043
            |...:             |...::|            |.|:|...:..:| ||..|.:|.:|.:.
Mouse  1034 WNTSNLSHDNQRKYIFNDEEGQNQLGTQTHQDIPLPPRRRELPASLTTNG-KADSLNVARNSVMQ 1097

  Fly  1044 NHHHLKERPPLL-GNLSLAASAQDLYRWSYKTEIAEME 1080
            ....|:::..:: ..|.||.|.        |||:.|.:
Mouse  1098 ELSELEKQIQVIRQELQLAVSR--------KTELEEYQ 1127

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	78/360 (22%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	145/415 (35%)
		Lig_chan	665..928	CDD:278489	90/268 (34%)
Grin3a	NP_001263284.1	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372	76/357 (21%)
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	143/408 (35%)
		Lig_chan	676..942	CDD:278489	93/277 (34%)
		PPP2CB binding site. /evidence=ECO:0000250|UniProtKB:Q9R1M7	951..987		5/35 (14%)
		GIT1-binding. /evidence=ECO:0000250|UniProtKB:Q9R1M7	1082..1115		8/33 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846523
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740