Protein Alignment Nmdar2 and Grin3a

DIOPT Version :10

• Sequence 1: NP_001014714.1
• Gene: Nmdar2 / 31107
• FlyBaseID: FBgn0053513
• Length: 1083
• Species: Drosophila melanogaster
• Sequence 2: NP_612555.1
• Gene: Grin3a / 191573
• RGDID: 621704
• Length: 1135
• Species: Rattus norvegicus
• Alignment Length: 1022
• Identity: 267/1022 - (26%)
• Similarity: 450/1022 - (44%)
• Gaps: 172/1022 - (16%)

  Fly   160 PTAILSTLCKEFLRVNVSAILYMMNNEQFGHSTASAQYFLQLAGYLGIPVISWNADNSGLER--- 221
            |.:.|.::|...:...|||:|      .|..|.........::..|.|||:|       :.|
  Rat   177 PFSFLQSVCHTVVVQGVSALL------AFPQSQGEMMELDLVSSVLHIPVLS-------IVRHEF 228

  Fly   222 -RASQSTLQLQLA--PSIEHQSAAMLSILERYKWHQFSVVTSQIAGHDDFVQAVRERVAEMQEHF 283
             |.||:.|.|||:  .|:...:...:|||....|:.||::..|    :|:  .:.:.:...:.:.
  Rat   229 PRESQNPLHLQLSLENSLSSDADVTVSILTMNNWYNFSLLLCQ----EDW--NITDFLLLTENNS 287

  Fly   284 KFTILNSIVVT----RTSDL-------MELVNSEARVMLLYATQTEAI-TILRAAEEMKLTGENY 336
            ||.:.:.|.:|    .|.||       |:.:.:....|:::....::| .|...:.:..|:....
  Rat   288 KFHLESVINITANLSSTKDLLSFLQVQMDNIRNSTPTMVMFGCDMDSIRQIFEMSTQFGLSPPEL 352

  Fly   337 VWVV--SQSVIEKKDAHSQFPVGMLGVHFDTSSAALMNEISNAIKIYSYGV-EAYLTDPANRDRR 398
            .||:  ||:|.|.:.  ...|:|:: .|..|:.:.....:.:|:::.:..| .|.:..|   :..
  Rat   353 HWVLGDSQNVEELRT--EGLPLGLI-AHGKTTQSVFEYYVQDAMELVARAVATATMIQP---ELA 411

  Fly   399 LTTQSLSCEDEGRGRWDNGEIFFKYLRNVSIEGDLNKPNIEFTADGDLR-------SAE--LKIM 454
            |...:::|.|.......:|:...::|.|.:..|          ..|.::       |:|  ..|.
  Rat   412 LLPSTMNCMDVKTTNLTSGQYLSRFLANTTFRG----------LSGSIKVKGSTIISSENNFFIW 466

  Fly   455 NLRPSANNKNLVWEEIGVWKSWETQKLDIRDIAWP--GNSHAPPQGVPEKFHLKITFLEEAPYI- 516
            ||:.....|.: |..:|   ||:..::.:....||  ...|......|.|.||::..|.|.|::
  Rat   467 NLQHDPMGKPM-WTRLG---SWQGGRIVMDSGIWPEQAQRHKTHFQHPNKLHLRVVTLIEHPFVF 527

  Fly   517 -------NLSPA-----DPVSGKCLMDRGVLCRVAAD-HEMAADIDVGQAHRNESFYQCCSGFCI 568
                   .|.||     ||::.    |..:|.|:.:. |.....:.:       .|.:||.|:||
  Rat   528 TREVDDEGLCPAGQLCLDPMTN----DSSMLDRLFSSLHSSNDTVPI-------KFKKCCYGYCI 581

  Fly   569 DLLEKFAEELGFTYELVRVEDGKWGTLENGKWNGLIADLVNRKTDMVLTSLMINTEREAVVDFSE 633
            ||||:.||::.|.::|..|.|||:|..:||.|.||:.||::...:|.:||..|||.|..|:||:.
  Rat   582 DLLEQLAEDMNFDFDLYIVGDGKYGAWKNGHWTGLVGDLLSGTANMAVTSFSINTARSQVIDFTS 646

  Fly   634 PFMETGIAIVVAKRTGIISPTAFLEPFDTASWMLVGI-VAIQAATFMIFLFEWLSPSGYDMKLYL 697
            ||..|.:.|:|..|.......||:.|.....|:  || ||:......:.|:||.||.|...|  .
  Rat   647 PFFSTSLGILVRTRDTAAPIGAFMWPLHWTMWL--GIFVALHITAIFLTLYEWKSPFGMTPK--G 707

  Fly   698 QNTNVTPYRFSLFRTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAAFMI 762
            :|.|..   ||......:.:|:||.....:..|:.:|.||:.|:||:|.:..|:.|||||||.|:
  Rat   708 RNRNKV---FSFSSALNVCYALLFGRTAAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMV 769

  Fly   763 TREEFHEFSGLNDSRLVHPFSHKPSFKFGTIPYSHTDSTIHKYFNVMHNYMRQYNKTSVADGVAA 827
            ..:.:.|.||::|.:|.||   ...|:|||:..|..:..:.:.|..||.|||:||..:..|||..
  Rat   770 GEKIYEELSGIHDPKLHHP---SQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNVPATPDGVQY 831

  Fly   828 VLNG--NLDSFIYDGTVLDYLVAQDEDCRLMTVGSWYAMTGYGLAFSRNSKYVQMFNKRLLEFRA 890
            :.|.  .||:||.|..:|||.|:.|.||:|:|||..:|:.|||:....||......::.:.::::
  Rat   832 LKNDPEKLDAFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTSNISELISQYKS 896

  Fly   891 NGDLERLRRYW-MTGTCRPGKQEHKSSDPL--ALEQFLSAFLLLMAGILLAALLLLLEHVYFKYI 952
            :|.::.|...| ....|  ||:....::.|  .::.|...|:||..|..|:.|..:.||:..:.:
  Rat   897 HGFMDVLHDKWYKVVPC--GKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVHRLL 959

  Fly   953 RKRLAKKD----GGHCCALISLSMGKSLTFRGAVFEATEILKKHRCNDPICDTH----------- 1002
            ..|:..|.    ..|.......::..|..........|:.::|.|.....|.|.
  Rat   960 LPRIKNKSKLQYWLHTSQRFHRALNTSFVEEKQPRSKTKRVEKSRWRRWTCKTEGDSELSLFPRS 1024

  Fly  1003 --------LWKVKH-------------ELDMSRL------------RVRQLEKVMDKHGIKAPQL 1034
                    :|...:             |...::|            |.|:|...:..:| ||..|
  Rat  1025 NLGPQQLMVWNTSNLSHDNQRKYIFNDEEGQNQLGTQAHQDIPLPQRRRELPASLTTNG-KADSL 1088

  Fly  1035 RLASSSDLLNHHHLKERPPLL-GNLSLAASAQDLYRWSYKTEIAEME 1080
            .:..||.:.....|:::..:: ..|.||.|.        |||:.|.:
  Rat  1089 NVTRSSVIQELSELEKQIQVIRQELQLAVSR--------KTELEEYQ 1127

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..485	CDD:380601	75/354 (21%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	146/423 (35%)
Grin3a	NP_612555.1	PBP1_iGluR_NMDA_NR3	40..496	CDD:380600	75/357 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	60..117
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	144/416 (35%)
		Lig_chan	674..941	CDD:459656	93/278 (33%)
		PPP2CB binding site. /evidence=ECO:0000269|PubMed:11588171	951..987		5/35 (14%)
		GIT1-binding. /evidence=ECO:0000269|PubMed:24297929	1082..1115		8/33 (24%)