Protein Alignment Nmdar2 and glr-2

DIOPT Version :10

• Sequence 1: NP_001014714.1
• Gene: Nmdar2 / 31107
• FlyBaseID: FBgn0053513
• Length: 1083
• Species: Drosophila melanogaster
• Sequence 2: NP_001021114.1
• Gene: glr-2 / 175999
• WormBaseID: WBGene00001613
• Length: 977
• Species: Caenorhabditis elegans
• Alignment Length: 1013
• Identity: 215/1013 - (21%)
• Similarity: 385/1013 - (38%)
• Gaps: 248/1013 - (24%)

  Fly    97 NKEQLNIGLI------APHTNFGKREYLRS--INN--AVTGLTKTRGAKLTF--LKDYSFEQKNI 149
            ||..|..|.:      .....|..|.::.|  |:|  |...:...|.|::||  |.|..|:   :
 Worm     2 NKNLLVFGFLIFVKIGETSKKFPLRAFVASTDIDNDTAHAIIEMLRLAEMTFNALSDVDFD---V 63

  Fly   150 HFDMMSLTPSPTAIL-----STLCKEFLRVNVSAILYMMNNEQFGHSTASAQYFLQLAGYLGIPV 209
            ......|.|...|.:     ..:|.| :::....:|...|.:.:|       .:..:|.::.:|:
 Worm    64 LLGTRDLPPMEMATMMWNLNRIICDE-MKLGYMLMLAGTNFKNYG-------IYEDIANHMKMPL 120

  Fly   210 ISWNADNS-GLERRASQSTLQLQLAPSIEHQSAAMLSILERYKWH-----------------QFS 256
            |.|....| .:.:....:.:...:|||.|.   .::..::...|.                 .||
 Worm   121 IDWEPSKSENIGKTTENNPMIFSVAPSAEQ---LLIDYIQYKGWRDVVYIHDGKNADRTLRTMFS 182

  Fly   257 VVTSQIAGHDDFVQAVRERVAEMQEHFKFTILNSI---VVT----RTSDLMELVNSEARVMLL-- 312
            .:..:...:..||.   ..||...|......||..   :.|    :::|..|.::....|.::
 Worm   183 YLHEKSPKYQLFVD---NYVAPSDEEMFKEFLNEFHRRISTQHTLKSNDSSEEIDEPIPVNVIVD 244

  Fly   313 ----YATQTEAITILRAAEEMKLTGENYVWVVSQSVIEKKDAHSQFPVGMLGVH----FDTSSAA 369
                |.|:    ..|||.||..|..:.|.:|.|...:::.|. |.|...::.:.    ||.::..
 Worm   245 LEGSYRTR----AFLRALEESVLVKKEYHYVFSNFDVDETDL-SGFHFSLINITIFRIFDKNNKK 304

  Fly   370 LMNEISNAIKIYSYG---------VEAYLTDPA-----------------------------NRD 396
            .:...:....:|..|         ..|:..|..                             ||.
 Worm   305 FLKTRAEFHDVYRGGFSNTDSIPTAAAFAHDAILVAGKALQIAMNEHGKGIFDKSFVRHQLFNRG 369

  Fly   397 RRLTTQSLSC---EDEGRGR----WDNGEIFFKYLRNVSI---EGDLNKPNIEF-TADGDLRSAE 450
            |:    .|.|   ||:...|    :::|:...:.::.|.:   :|.|. ..|:| ...|...:..
 Worm   370 RK----GLYCRPHEDQTESRQFETFEHGKKIAEAIKKVVLTDKDGTLT-GRIQFDKVTGKRTNFS 429

  Fly   451 LKIMNLRPSANNKNLVWEE----------IGVWKSWETQKLDIRDIAWPGNSHAPPQGV----PE 501
            .:|:.::|..|:.|.:||.          :|..:..:.:|.|         |....:|:    |.
 Worm   430 AEIVEIKPGVNSLNSIWERFQWAEGEGFLLGGERYVQEKKKD---------SSQTRKGILPSKPW 485

  Fly   502 KFHLKITFLEEAPYINL---SPADPVSGKCLMDRGVLCRVAADHEMAADIDVGQAHRNESFYQCC 563
            :....:..:...|::.|   :|.:|                            :...|:.|
 Worm   486 QLRFNVVTVLVKPFVMLKRRNPGEP----------------------------ELKGNDRF---- 518

  Fly   564 SGFCIDLLEKFAEEL-GFTYELVRVEDGKWGTLE-NGKWNGLIADLVNRKTDMVLTSLMINTERE 626
            .|:|||||...|:.: ||.|::...:..|:|:.: :|.|:|:|..|:|...|:.:..|.|..|||
 Worm   519 EGYCIDLLNLLAKNITGFEYDVFISDGNKYGSRQADGSWDGMIGYLLNETADVAVAPLTITQERE 583

  Fly   627 AVVDFSEPFMETGIAIVVAK----RTGIISPTAFLEPFDTASWMLVGIVAIQAATFMIFLFEWLS 687
            ..||||:|||.|||:|::.|    ...|.|   |:||.....|:.. :.:....:..|||..|.|
 Worm   584 RAVDFSKPFMTTGISIMIKKPEKQEFNIFS---FMEPLGMTIWIFT-LSSYFGVSLTIFLVSWFS 644

  Fly   688 PSGYDMKLYLQNTNVT-PYRFSLFRTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLA 751
            |  |:.::..:....| ...|:|:.:.|...|...|....: .||..:.|..::.|..|.::.::
 Worm   645 P--YEKRIEFKRGEFTVTNEFTLYNSLWFTLAAFMQQGTDI-LPRAVSGRIASSCWWFFTLIIVS 706

  Fly   752 IYTANLAAFMITR------EEFHEFSGLNDSRLVHPFSHKPS----FKFGTIP------------ 794
            .||||||||:...      |...:.:  |.:::::..:...|    |:...:|
 Worm   707 SYTANLAAFLTLERMTPPIESVEDLA--NQNKILYGVNEGGSTAAFFEDSIVPLYKKMWNFMVST 769

  Fly   795 ---------YSHTDSTIHKYFNVMHNYMRQYNKTSVADGVAAV-LNGNLDSFIYDGTVLDYLVAQ 849
                     .|.|:||.::.|           .:|.|||:..| .:....:|:.:.|..:|...:
 Worm   770 TQKQIELEKQSITNSTSNRIF-----------VSSYADGIEKVRTSKGKYAFLLEETTNNYESGR 823

  Fly   850 DEDCRLMTVGSWYAMTGYGLAFSRNSKYVQMFNKRLLEFRANGDLERLRRYWM--TGTCRPGKQE 912
             ..|..|.||......|||:|....:......|..:|.....|:|::|...|.  .|.|..|..:
 Worm   824 -RPCDTMKVGQNLNTLGYGIATKIGNPLRVSLNLAILYLSEKGELKKLENKWWYDRGQCDTGTSD 887

  Fly   913 HKSSDPLALEQFLSAFLLLMAGILLAALLLLLEHVYFK 950
            ..:|..|.|.:....|.:|:||::|:....|:|.::.|
 Worm   888 GGTSSSLNLSKVAGIFYILLAGMVLSMCTALVEFLFRK 925

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..485	CDD:380601	90/496 (18%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	108/449 (24%)
glr-2	NP_001021114.1	PBP1_iGluR_AMPA	24..460	CDD:380603	84/462 (18%)
		Periplasmic_Binding_Protein_Type_2	491..875	CDD:473866	105/436 (24%)