Protein Alignment Nmdar2 and glr-4

DIOPT Version :10

• Sequence 1: NP_001014714.1
• Gene: Nmdar2 / 31107
• FlyBaseID: FBgn0053513
• Length: 1083
• Species: Drosophila melanogaster
• Sequence 2: NP_001254126.1
• Gene: glr-4 / 174258
• WormBaseID: WBGene00001615
• Length: 951
• Species: Caenorhabditis elegans
• Alignment Length: 929
• Identity: 203/929 - (21%)
• Similarity: 358/929 - (38%)
• Gaps: 207/929 - (22%)

  Fly    95 AANKEQLNIGLIAPHTNFGKREYLRSINNAVTGLTKTRGAKLTFLKDYSFEQKNIHFDMMSLTPS 159
            :|..::.:||.||...:|. .|:||   .|:.......||           ...|.|.::|....
 Worm    23 SAADDRFHIGTIANRGSFA-YEHLR---YAIDRWNTEHGA-----------HTQIKFSIVSPIRY 72

  Fly   160 PTAILSTLCKEFLRVNVSAILYMMNNEQFGHSTASAQYFLQLAGYLGIPVISWNADNSGLERRAS 224
            .......:| |.::..:.|:  :::||:   |...:|....:..|..||.:|..:.:    .|.|
 Worm    73 DNNYEERMC-EIMQQGIVAV--VLSNEE---SEQDSQLIKSMCHYFNIPCLSLQSTS----LRDS 127

  Fly   225 QSTLQLQLAPSIEHQSAAMLSILERYKWHQFSVV---------TSQIAGHDDFVQAVRERVAEMQ 280
            .|.....|.||....:.|....|:..:|..|.:.         .|.:..:...|.....|:
 Worm   128 VSDFVTLLGPSRGAGARATSEFLDSMRWTGFLLAYQHGSDLEDLSPLMQYKQIVDTGGRRI---- 188

  Fly   281 EHFKFTILNS----------IVVTRTSDLMELVNSEARVMLLYATQTEAITILRAAEEMKLTGEN 335
             |.|...|.:          .|.||......:::|. .:.:||       .:|:.|..:.:....
 Worm   189 -HIKIRRLPNNTDDYEPFLKYVKTRLKQTNIIIHSN-NITVLY-------NLLQQARGLNMAEPP 244

  Fly   336 YVWVVSQ---SVIEKKDAHSQFPVGMLGVHFDTSSAAL-------MNEISNAI---KIYSYGVEA 387
            :.:|.:.   |::|      .|...|.|..|..:...|       |.:...|:   .:|..|:..
 Worm   245 FSYVFTNTDLSLLE------DFLNNMYGASFHCNITGLQLVKNDPMMKTQLALTSEAVYVVGMSI 303

  Fly   388 YLTDPANRDRRL----TTQSLSCEDEGRGRWDNGEIFFKYLRNVSIEGDLNKPNIEFTADGD--- 445
            |      |.|.|    ...|:.|  :....|.:|.|..:.:|.:.:...|. .:::|.::|:
 Worm   304 Y------RMRELGHAPRQSSIMC--DSHDIWSDGRIMNEGIRKLKLRNQLT-GDVQFKSNGERDD 359

  Fly   446 --------LRSAELKIMNLRPSANNKNLVWEEIGVW-------KSWETQKLDIRDIAWPGNSHAP 495
                    :.|..:|:.|           |.|...|       ..||   .||          .|
 Worm   360 IMYHGVGRINSQFVKLGN-----------WSEKRGWNFDSRYANRWE---FDI----------DP 400

  Fly   496 PQGVPEKFHLKITFLEEAPYINLSPADPVSGKCLMDRGVLCRVAADHEMAADIDVGQAHRNESFY 560
            .....|..||::....|.|::                               |..|     |:.|
 Worm   401 DSEDLEGLHLRVVVYLEEPFV-------------------------------IKTG-----ENQY 429

  Fly   561 QCCSGFCIDLLEKFAEELGFTYELVRVEDGKWGTL-ENGKWNGLIADLVNRKTDMVLTSLMINTE 624
            :   |||||||.:..:.|.|.|.::.|:||.:|.. |:|:|||:|..|...:.|:.|:::.|...
 Worm   430 E---GFCIDLLNEMTQVLKFNYTIIEVQDGTYGIEDESGRWNGIIGALQRHEADLSLSAVTITYS 491

  Fly   625 REAVVDFSEPFMETGIAIVVAK---RTGIISPTAFLEPFDTASW--MLVGIVAIQAATFMIFLF- 683
            |..||||:.|||..||:|::|:   .|...|...||||.....|  :|:....:..:..::..|
 Worm   492 RAEVVDFTLPFMHLGISILLARTSEETDKGSLWTFLEPLSLTVWISLLISYCIVSYSMHILAKFS 556

  Fly   684 --EWLSPSGYDMKLYLQNTNVTPYRFSLFRTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFA 746
              ||.:....|.:.: :|......:|::..::|.....|.|....| .||...:|.:..||.:|.
 Worm   557 PYEWYNLERIDERDF-ENIKNQKNQFTVLNSFWFTMGSLMQQGSDV-IPRAAATRLIAVVWWMFT 619

  Fly   747 VVFLAIYTANLAAFMITREEFHEFSGLNDSRLVHPFSHKPSFKFGTIPYSHT-----DSTIHKY- 805
            .:.::.|||.||||:.............|      .:::...::|.:....|     :|.|..|
 Worm   620 QIIISSYTAQLAAFLTVERMSTPIESTQD------LANQQKIRYGVLKSGSTMDFFRESKIPMYE 678

  Fly   806 --FNVMHNYMRQYNKTSVADGVAAVLNGNLDSFIYDGTVLDYLVAQDEDCRLMTVGSWYAMTGYG 868
              ::||.:........|..:|:|.|.:|.. :::.:.::|:|.:  :.||.|.::|......|||
 Worm   679 RMWSVMESSSPGVFVNSSREGIARVKSGGY-AYMMESSMLEYYL--ERDCELQSIGGLLDSKGYG 740

  Fly   869 LAFSRNSKYVQMFNKRLLEFRANGDLERLRRYWMTG-----TCRPGKQEH-KSSDPLALEQFLSA 927
            :|..:.|....:.::.:|:.:....||.|:..|...     :|.|...|. .:|.|   :.....
 Worm   741 IALPKGSPLRDILSRTVLQLQERTILEALKNKWWRDRREGPSCGPPPSEKATNSKP---QNIFGI 802

  Fly   928 FLLLMAGILLAALLLLLEH 946
            |.:|:.|:::|.||...|:
 Worm   803 FYVLLTGLIVAFLLACGEY 821

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..485	CDD:380601	84/439 (19%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	105/427 (25%)
glr-4	NP_001254126.1	Periplasmic_Binding_Protein_type1	30..385	CDD:471960	79/418 (19%)
		Periplasmic_Binding_Protein_Type_2	410..775	CDD:473866	103/414 (25%)