DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar2 and Grin3b

DIOPT Version :9

Sequence 1:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster
Sequence 2:	XP_006513350.1	Gene:	Grin3b / 170483	MGIID:	2150393	Length:	1138	Species:	Mus musculus

Alignment Length:	1041	Identity:	262/1041 - (25%)
Similarity:	447/1041 - (42%)	Gaps:	186/1041 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 RGTD--GPTPTPTPMPT-TMRKHTPIATLNTASCQHNSTTSRRKRILTPPSGPISLLLLTVLTL- 70
            |||.  |..|.|.|:.| |.|::...|..:.:...|::..:             |:.:..|.||
Mouse    37 RGTANLGSGPAPPPVDTRTGRRNESGAGWDVSLPSHSTVVT-------------SIGMECVQTLW 88

  Fly    71 LILDTRSCQGLRLTNG-----GGSLSKGAAANKEQLNIGLIAPHTNFGKREYLRSINNAVTGLTK 130
            |.|.....:|..:..|     |.....||:     :.:..:.|.....:...|.::        .
Mouse    89 LSLALALARGSWVVRGHPQPCGVPTRAGAS-----VRLAALLPRAPAARARVLAAL--------A 140

  Fly   131 TRGAKLTFLKDYSFEQKNIHFDMMSL---TPSPTAILSTLCKEFLRVNVSAILYMMNNEQFGHST 192
            |...:|         ..|:..:::::   |..|.::...||:......|.|.:      .|..:.
Mouse   141 TPSPRL---------PHNLSLELVAVASPTRDPASLARGLCQVLAPPGVVASI------TFPEAR 190

  Fly   193 ASAQYFLQLAGYLGIPVISWNADNSGLERRASQST--------LQLQLAPSIEHQSAAMLSILER 249
            ...:....||.....||:|       :.||..::.        |||..|..:|.....::|::..
Mouse   191 PELRLLQFLAAATETPVLS-------VLRREVRAPLGAPTPFHLQLDWASPLETILDVLVSLVRA 248

  Fly   250 YKWHQFSVVTSQIAGHDDFVQAVRERVAEMQEHFKFTILNSIVVTRTSDLMEL--VNSEARVMLL 312
            :.|...::|..::......|.....|.::..   ||.:          ||.:|  .|...|..|.
Mouse   249 HAWEDIALVLCRVRDPSGLVTLWTSRASQAP---KFVL----------DLSQLDSGNDSLRATLA 300

  Fly   313 Y-------ATQTEAITIL-----RAAEEMKLTGENYVWVVSQSVIEKKDAHSQFPVGMLGVHFDT 365
            .       .|...|..:|     .|.|.::.......|::...:..:....:..|.|:| |..:|
Mouse   301 LLGTLEGGGTPVSAAVLLGCSTAHAHEVLEAAPPGPQWLLGTPLPAEALPKTGLPPGVL-VLGET 364

  Fly   366 SSAALMNEISNAIKIYSYGVEAY-LTDPANRDRRLTTQSLSCED-EGRGRWDNGEIFFKYLRNVS 428
            ...:|...:.:.:::.:..:.:. |..|   :|.|...:::||| :..|.........::|.|.|
Mouse   365 GQPSLEAAVHDMVELVARALSSMALMHP---ERALLPAAVNCEDLKTGGSESTARTLARFLSNTS 426

  Fly   429 IEGDLNKPNIEFTADGDLRSAELKIMNLR------PSANNKNLVWEEIGVWKSWETQKLDIRDIA 487
            .:|......:..::...: |...|:.:||      |:       |..:|   ||:..:||.:
Mouse   427 FQGRTGAVWVAGSSQVHV-SRHFKVWSLRRDPLGAPA-------WATVG---SWQDGQLDFQ--- 477

  Fly   488 WPGNS--HAP-PQGVPEKFHLKITFLEEAPYINLSPADPVSGKCLMDRGVLCRVAADHEMA---- 545
             ||.:  ..| |.|...:..|::..|.|.|::....:|. .|:|  ..|.||.....::.|
Mouse   478 -PGAAALRVPSPSGTQARPKLRVVTLVEHPFVFTRESDE-DGQC--PAGQLCLDPGTNDSARLDA 538

  Fly   546 --ADIDVGQAHRNESFYQCCSGFCIDLLEKFAEELGFTYELVRVEDGKWGTLENGKWNGLIADLV 608
              ..::.|...|  :..:||.|:||||||:.||:|.|.:||..|.|||:|.|.:|:|.||:.||:
Mouse   539 LFTALENGSVPR--TLRRCCYGYCIDLLERLAEDLAFDFELYIVGDGKYGALRDGRWTGLVGDLL 601

  Fly   609 NRKTDMVLTSLMINTEREAVVDFSEPFMETGIAIVVAKRTGIISPTAFLEPFDTASWMLVGI-VA 672
            ..:..|.:||..||:.|..||||:.||..|.:.|:|..|.......||:.|...:.|  ||: .|
Mouse   602 AGRAHMAVTSFSINSARSQVVDFTSPFFSTSLGIMVRTRDTASPIGAFMWPLHWSMW--VGVFAA 664

  Fly   673 IQAATFMIFLFEWLSPSGYDMKLYLQNTNVTPYR------FSLFRTYWLVWAVLFQAAVHVDSPR 731
            :......:.|:||.||.|           :||..      ||......|.:|:||...|...:|:
Mouse   665 LHLTALFLTLYEWRSPYG-----------LTPRGRNRGTVFSYSSALNLCYAILFGRTVSSKTPK 718

  Fly   732 GFTSRFMTNVWALFAVVFLAIYTANLAAFMITREEFHEFSGLNDSRLVHPFSHKPSFKFGTIPYS 796
            ..|.||:.|:||:|.::.|:.|||||||.|:..:.|.|.||::|.:|.||   ...|:|||:..|
Mouse   719 CPTGRFLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDPKLHHP---SQGFRFGTVWES 780

  Fly   797 HTDSTIHKYFNVMHNYMRQYNKTSVADGVAAVLNG--NLDSFIYDGTVLDYLVAQDEDCRLMTVG 859
            ..::.|...|..||.:||:::..:...|||.:.:.  .|::||.|.::|||.|:.|.||:|:|||
Mouse   781 SAEAYIKASFPEMHAHMRRHSAPTTPHGVAMLTSDPPKLNAFIMDKSLLDYEVSIDADCKLLTVG 845

  Fly   860 SWYAMTGYGLAFSRNSKYVQMFNKRLLEFRANGDLERLRRYWMTGT-CRPGKQEHKSSDPLALEQ 923
            ..:|:.|||:...:||......::.:..::::|.::.|...|.... |  ||:....::.|.:..
Mouse   846 KPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDKWYKMVPC--GKRVFAVTETLQMGV 908

  Fly   924 F-LSA-FLLLMAGILLAALLLLLEHVYFKYIRKRLAK--------------------KDGGHCCA 966
            : ||. |:||..|:..|.|..|.|||:::.:..|:.:                    :.|||..:
Mouse   909 YHLSGLFVLLCLGLGSALLTSLGEHVFYRLVLPRIRRGNKLQYWLHTSQVRRQDKVGRGGGHLRS 973

  Fly   967 L 967
            |
Mouse   974 L 974

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	72/423 (17%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	142/421 (34%)
		Lig_chan	665..928	CDD:278489	88/274 (32%)
Grin3b	XP_006513350.1	PBP1_iGluR_NMDA_NR3	141..481	CDD:380600	72/393 (18%)
		PBP2_iGluR_NMDA_Nr3	494..888	CDD:270438	140/414 (34%)
		Lig_chan	656..922	CDD:365843	91/283 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846657
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740