Protein Alignment Nmdar2 and gria2b

DIOPT Version :10

• Sequence 1: NP_001014714.1
• Gene: Nmdar2 / 31107
• FlyBaseID: FBgn0053513
• Length: 1083
• Species: Drosophila melanogaster
• Sequence 2: XP_068069253.1
• Gene: gria2b / 170451
• ZFINID: ZDB-GENE-020125-4
• Length: 944
• Species: Danio rerio
• Alignment Length: 1012
• Identity: 228/1012 - (22%)
• Similarity: 379/1012 - (37%)
• Gaps: 261/1012 - (25%)

  Fly    60 ISLLLLTVLTLLILDTRSCQGLRLTNG-------GGSLSKGAAANKEQLNIGLIAPHTNFGKREY 117
            :|:.|:.:|            |.:|.|       ||...:||........||::    .||..|:
Zfish     7 LSICLIALL------------LGMTTGGSPSVQIGGLFPRGADQEYSAFRIGMV----QFGTAEF 55

  Fly   118 LRSINNAVTGLTKTRGAKLTFLKDYSFEQKNIHFDMMSLTPSPTAILSTLCKEFLRVNVSAILYM 182
                             :||           .|.|.:.:..| .|:.:..|.:|.| .|.||
Zfish    56 -----------------RLT-----------PHIDNLEVANS-FAVTNCFCSQFSR-GVYAI--- 87

  Fly   183 MNNEQFG-HSTASAQYFLQLAGYLGIPVISWNADNSGLERRASQSTLQLQLAPSIEHQSAAMLSI 246
                 || :...|........|.|.:..|:.:....|.::      ..:|:.|.|:   ..:||:
Zfish    88 -----FGFYDKKSVNTITSFCGTLHVSFITPSFPLDGNQQ------FIIQMRPDIK---GPLLSL 138

  Fly   247 LERYKWHQFSVVTSQIAGHDDFVQAVRERVAEMQEHFKFTILNSIVVTRTSD----------LME 301
            :|.|||.:|:.:.....|... :|.|.:..||  :.::.|.:|   |....|          ..:
Zfish   139 IEYYKWDKFAYLYDSDRGLTT-LQVVLDTAAE--KKWQVTAIN---VGNMKDERKDEAYRSLFQD 197

  Fly   302 LVNSEARVMLLYATQTEAITILRAAEEMKLTGENYVWVVSQ--------SVIEKKDAH-SQFPVG 357
            |.|.:.|.::|...|.:...|:.....:....:.|.::::.        |.|:...|: |.|.:
Zfish   198 LENKKERRVILDCEQDKVKDIMEQVITIGRHVKGYHYIIANLGFVDGDLSKIQYGGANVSGFQI- 261

  Fly   358 MLGVHFDTSSAALMNEISNAIKIYSY-GVEAYL--TDPANRD---------RRLTTQSL------ 404
               |.||....:..::...|::...| |.::.:  |.....|         |.|..|.:
Zfish   262 ---VDFDDPLVSKFDQRWEALEEKEYPGADSKIRYTSALTYDAVQVMTEAFRYLHKQRIDISRRA 323

  Fly   405 ---SCEDEGRGRWDNGEIFFKYLRNVSIEGDLNKPNIEFTADGDLRSAELKIMNLRPSANNKNLV 466
               .|.......|..|....:.|:.|.::|...  ||:|...|...:..:.:|.|:.:...|
Zfish   324 NNGDCLANPAVPWAQGVEIERALKQVRVDGLTG--NIQFDQYGKRVNYTVNVMELKSNGAVK--- 383

  Fly   467 WEEIGVWKSWETQKLDIRDIAWPGNSHAPPQGVPEKFHLKITFLEEAPYINLSPADPVSGKCLMD 531
               ||.|...:...:...|: :|.::    .|:..|..:..|.| ||||:.|..    :....||
Zfish   384 ---IGYWNEVDKMVVTKSDL-FPNDT----MGLENKTVIVTTIL-EAPYVMLKK----NADLFMD 435

  Fly   532 RGVLCRVAADHEMAADIDVGQAHRNESFYQCCSGFCIDLLEKFAEELGFTYELVRVEDGKWGT-- 594
                                    ||.:    .|:|:||..:.|:..||.|:|..|.|||:|.
Zfish   436 ------------------------NERY----EGYCVDLAAEIAKHCGFKYQLKIVGDGKYGARD 472

  Fly   595 LENGKWNGLIADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGIAIVVAK----RTGIISPTA 655
            .|...|||::.:||..|.|:.:..|.|...||.|:|||:|||..||:|::.|    :.|:.|
Zfish   473 AETKIWNGMVGELVYGKADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFS--- 534

  Fly   656 FLEPFDTASWMLVGIVAIQAATFMIFLFEWLSPSGYDMKLYLQ---NTNVTPYRFSLFRTYWLVW 717
            ||:|.....||.: :.|....:.::||....||..:..:.|..   .||.:...|.:|.:.|...
Zfish   535 FLDPLAYEIWMCI-VFAYIGVSVVLFLVSRFSPYEWHTEEYEDGQIQTNESTNEFGIFNSLWFSL 598

  Fly   718 AVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAAFMITREEFHEFSGLNDSRLVHP- 781
            ....:....: |||..:.|.:..||..|.::.::.||||||||            |...|:|.|
Zfish   599 GAFMRQGCDI-SPRSLSGRIVGGVWWFFTLIIISSYTANLAAF------------LTVERMVSPI 650

  Fly   782 -----FSHKPSFKFGTIPYSHTDSTIHK----YFNVMHNYMR-----QYNKTSVADGVAAVLNG- 831
                 .:.:....:||:....|.....:    .|:.|..||:     .:.||: |:||..|...
Zfish   651 ESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIALFDKMWTYMKGAEPSVFVKTT-AEGVMRVRKSK 714

  Fly   832 NLDSFIYDGTVLDYLVAQDEDCRLMTVGSWYAMTGYGLAFSRNSKYVQMFNKRLLEFRANGDLER 896
            ...:::.:.|:.:| :.|.:.|..|.||......|||:|..:.|......|..:|:....|.|::
Zfish   715 GKYAYLLESTMNEY-IEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLLDK 778

  Fly   897 LRRYWM--TGTCRPGKQEHKSS------------------------------------------- 916
            |:..|.  .|.|..|..:.|.|
Zfish   779 LKNKWWYDKGECGSGGGDSKVSPREQSDGTPVNLAVLKLSEQGTLDKLKNKWWYDKGECGAKDSG 843

  Fly   917 -----DPLALEQFLSAFLLLMAGILLAALLLLLEHVY 948
                 ..|:|......|.:|:.|:.||.|:.|:|..|
Zfish   844 SKEKTSALSLSNVAGVFYILVGGLGLAMLVALVEFCY 880

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..485	CDD:380601	82/426 (19%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	119/432 (28%)
gria2b	XP_068069253.1	PBP1_iGluR_AMPA_GluR2	27..397	CDD:380612	86/438 (20%)
		PBP2_iGluR_AMPA	410..790	CDD:270433	118/431 (27%)