DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Nmdar2 and Grin2c

DIOPT Version :9

Sequence 1:NP_001014714.1 Gene:Nmdar2 / 31107 FlyBaseID:FBgn0053513 Length:1083 Species:Drosophila melanogaster
Sequence 2:XP_017169765.1 Gene:Grin2c / 14813 MGIID:95822 Length:1307 Species:Mus musculus


Alignment Length:1013 Identity:292/1013 - (28%)
Similarity:489/1013 - (48%) Gaps:147/1013 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 PMPTTMRK------------------HTPIATLNTASCQHNSTTSRRKRILTPP------SGPIS 61
            |:|...||                  |.|::.....|.|            .||      .|| :
Mouse    19 PLPLLCRKVLCTLAVCVFSGPYLLFVHLPLSVPALISLQ------------DPPVDMGGALGP-A 70

  Fly    62 LLLLTVLTLLILDTRSCQGLRLTNGGGSLSKGAAANKEQLNIGLIAPHTNFGKREYLRSINNAVT 126
            |||.::|                  |.....||...::.:.:.::     ||.       :..:.
Mouse    71 LLLTSLL------------------GAWAGLGAGQGEQAVTVAVV-----FGS-------SGPLQ 105

  Fly   127 GLTKTRGAKLTFLKDYSFEQKNIHFDMMSLT-----PSPTAILSTLCKEFLRVNVSAILYMMNNE 186
            ...:||.....||        ::..::..||     .:|::||:.:|.......|..|::..|.:
Mouse   106 AQARTRLTPQNFL--------DLPLEIQPLTIGVNNTNPSSILTQICGLLGAARVHGIVFEDNVD 162

  Fly   187 QFGHSTASAQYFLQLAGYLGIPVISWNADNSGLERRASQSTLQLQLAPSIEHQSAAMLSILERYK 251
                :.|.||....::....:|::|.:..::.:.......:..|||..|:|.|...:..:||.|.
Mouse   163 ----TEAVAQLLDFVSSQTHVPILSISGGSAVVLTPKEPGSAFLQLGVSLEQQLQVLFKVLEEYD 223

  Fly   252 WHQFSVVTSQIAGHDDFVQAVRERVAEMQEHFKFTILNSIVV--------TRTSDLMELVNSEAR 308
            |..|:|:||...||..|::.|| .||: ..:..:.:|:.:.:        .||..|:..|  :|.
Mouse   224 WSAFAVITSLHPGHALFLEGVR-AVAD-ASYLSWRLLDVLTLELGPGGPRARTQRLLRQV--DAP 284

  Fly   309 VMLLYATQTEAITILRAAEEMKLTGENYVWVVSQSVIEKKDA-HSQFPVGMLGVHFDTSSAALMN 372
            |::.|.::.||..:...|.:..|.|..:||:|....:...|| .:.||||::.|..::...:|..
Mouse   285 VLVAYCSREEAEVLFAEAAQAGLVGPGHVWLVPNLALGSTDAPPAAFPVGLISVVTESWRLSLRQ 349

  Fly   373 EISNAIKIYSYGVEAY------LTDPANRDRRLTTQSLSCEDEGRGRWDNGEIFFKYLRNVSIEG 431
            ::.:.:.|.:.|..:|      |..||.          .|...........|.|:::|.||:.||
Mouse   350 KVRDGVAILALGAHSYRRQYGTLPAPAG----------DCRSHPGPVSPAREAFYRHLLNVTWEG 404

  Fly   432 DLNKPNIEFTADGDLRSAELKIMNLRPSANNKNLVWEEIGVWKSWETQKLDIRDIAWPGNSHAPP 496
                .:..|:..|.|....:.::.|     |::.:||.:|   .|:...|.::...||..| ...
Mouse   405 ----RDFSFSPGGYLVQPTMVVIAL-----NRHRLWEMVG---RWDHGVLYMKYPVWPRYS-TSL 456

  Fly   497 QGVPEKFHLKITFLEEAPYINLSPADPVSGKCLMDRGVLCRVAADHEMAADIDVGQAHRNESFYQ 561
            |.|.:..||.:..|||.|::.:...||.:|.|:.:. |.||..::|..::. |:....:     .
Mouse   457 QPVVDSRHLTVATLEERPFVIVESPDPGTGGCVPNT-VPCRRQSNHTFSSG-DITPYTK-----L 514

  Fly   562 CCSGFCIDLLEKFAEELGFTYELVRVEDGKWGTLENGKWNGLIADLVNRKTDMVLTSLMINTERE 626
            ||.|||||:|:|.|:.:.|:|:|..|.:||.|....|.|||:|.::..::.||.:.||.||.||.
Mouse   515 CCKGFCIDILKKLAKVVKFSYDLYLVTNGKHGKRVRGVWNGMIGEVYYKRADMAIGSLTINEERS 579

  Fly   627 AVVDFSEPFMETGIAIVVAKRTGIISPTAFLEPFDTASWMLVGIVAIQAATFMIFLFEWLSPSGY 691
            .::|||.||:||||:::||:..|.:||:|||||:..|.|:::.::.:......:|:||:.||..|
Mouse   580 EIIDFSVPFVETGISVMVARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVSY 644

  Fly   692 DMKLYLQNTNVTPYRFSLFRTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTAN 756
            :..|.....:..| .|::.::.||:||::|..:|.:::|||.||:.|..|||.|||:|||.||||
Mouse   645 NQNLTKGKKSGGP-SFTIGKSVWLLWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTAN 708

  Fly   757 LAAFMITREEFHEFSGLNDSRLVHPFSHKPSFKFGTIPYSHTDSTIHKYFNVMHNYMRQYNKTSV 821
            ||||||..:.....|||:|.:...|....|.|:|||:|...|:..|...:..||.:|.::|:.||
Mouse   709 LAAFMIQEQYIDTVSGLSDKKFQRPQDQYPPFRFGTVPNGSTERNIRSNYRDMHTHMVKFNQRSV 773

  Fly   822 ADGVAAVLNG------NLDSFIYDGTVLDYLVAQDEDCRLMTVGSW--YAMTGYGLAFSRNSKYV 878
            .|.:.::..|      .||:||||..||:|:..:||.|:|:|:||.  :|.||||:|..::|.:.
Mouse   774 EDALTSLKMGARHVSRKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWK 838

  Fly   879 QMFNKRLLEFRANGDLERLRRYWMTGTCRPGKQEHKSSDPLALEQFLSAFLLLMAGILLAALLLL 943
            :..:..||:|..:|:.::|...|::|.|...|.|..|| .|.::.....|.:|:..:.||.|:..
Mouse   839 RAIDLALLQFLGDGETQKLETVWLSGICHNEKNEVMSS-KLDIDNMAGVFYMLLVAMGLALLVFA 902

  Fly   944 LEH-VYFKYIRKRLAKKDGGHCCALISLSMGKSLTFRG 980
            .|| ||:|.   |.:.........|::.|.|....|.|
Mouse   903 WEHLVYWKL---RHSVPSSSQLDFLLAFSRGIYSCFNG 937

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nmdar2NP_001014714.1 PBP1_iGluR_NMDA_NR2 99..490 CDD:107373 90/410 (22%)
PBP2_iGluR_NMDA_Nr2 502..908 CDD:270436 158/413 (38%)
Lig_chan 665..928 CDD:278489 98/270 (36%)
Grin2cXP_017169765.1 PBP1_iGluR_NMDA_NR2 90..446 CDD:380601 89/405 (22%)
PBP2_iGluR_NMDA_Nr2 462..868 CDD:270436 158/413 (38%)
NMDAR2_C 905..>980 CDD:371139 10/36 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167846658
Domainoid 1 1.000 214 1.000 Domainoid score I2719
eggNOG 1 0.900 - - E1_KOG1052
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 455 1.000 Inparanoid score I1578
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D279143at33208
OrthoFinder 1 1.000 - - FOG0000775
OrthoInspector 1 1.000 - - otm43044
orthoMCL 1 0.900 - - OOG6_102799
Panther 1 1.100 - - O PTHR18966
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3072
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1312.790

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